Antimüllerian hormone as a predictor of good-quality supernumerary blastocyst cryopreservation among women with levels &lt;1 ng/mL versus 1–4 ng/mL

Kavoussi, Shahryar K.; Odenwald, Kate C.; Boehnlein, Lynn M.; Summers-Colquitt, Roxanne B.; Pool, Thomas B.; Swain, Jason E.; Jones, Jeffrey M.; Lindstrom, Mary J.; Lebovic, Dan I.

doi:10.1016/j.fertnstert.2015.06.007

Cited by 16 publications

(10 citation statements)

References 24 publications

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“…There is an association between AMH and oocyte yield after ovarian stimulation, and the hormone has been shown to be a strong predictor of ovarian response to gonadotropins, whether satisfactory, poor or excessive, cycle cancellation, and of the quality of oocytes and embryos (La Marca et al ., 2005; Kavoussi et al ., 2015). …”

Section: Introductionmentioning

confidence: 99%

Prediction of metaphase II oocytes according to different serum Anti-Müllerian hormone (AMH) levels in antagonist ICSI cycles

Jb¹,

Tr²,

Ma³

et al. 2016

JBRA Assisted Reproduction

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ObjectiveThis paper aims to assess a qualitative aspect of ovarian response in terms of metaphase II oocytes according to different serum Anti-Müllerian hormone levels in antagonist ICSI cycles. A prediction index might contribute to the individualization of care.MethodsThis observational study looked into 287 antagonist ICSI cycles carried out with patients treated in a single center between January of 2012 and January of 2016. Serum AMH and subgroup analyses were performed based on five AMH ranges (≤ 0.3 ng/mL;> 0.3 and ≤ 0.7 ng/mL; > 0.7 and ≤ 1.0 ng/mL; > 1.0 and < 3.0 ng/mL; ≥ 3.0 ng/mL). The variables analyzed included patient age; serum FSH and antral follicle count at the start of the cycle; number of stimulation days and number follicles ≥ 15 mm on hCG day; number of oocytes retrieved and number of metaphase II oocytes.ResultsAMH is a better predictor of ovarian response to controlled ovarian stimulation than AFC or serum FSH, while age is an independent marker. AMH levels ≤0.70 (patients with poor prognosis) were observed in 140 patients (48.7%). Patients within this AMH level range accounted for 92% of the 24 failed cycles (cancelled cycles, no oocytes or immature oocytes retrieved).ConclusionAMH predicts the quality of ovarian response to stimulation, regardless of patient age. Women with AMH levels ≥1.0 and ≤3.0 ng/mL are probably normal responders with good prognosis. Clinical application relies on the examination of the data from each individual center and on the establishment of correlations between AMH levels and ovarian response in the form of metaphase II oocytes.

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Section: Introductionmentioning

confidence: 99%

Prediction of metaphase II oocytes according to different serum Anti-Müllerian hormone (AMH) levels in antagonist ICSI cycles

Jb¹,

Tr²,

Ma³

et al. 2016

JBRA Assisted Reproduction

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“…As previously explained, many published studies have described the clinical application of AMH measurement in the prediction of both, quantitative and qualitative ovarian response in ART [29]. There is an association between AMH and oocyte yield after ovarian stimulation, and the hormone has been shown to be a strong predictor of ovarian response to gonadotropins [17,27,39]. However, patients with undetectable AMH levels have been shown to successfully obtain oocytes at the time of retrieval and even to achieve ongoing pregnancy [40,41].…”

Section: Discussionmentioning

confidence: 99%

Lack of Predictive Value of Ovarian Reserve Tests for Pregnancy Likelihood. The Huge Difference Between Quantity and Quality

Barrenetxea

Martínez²,

Heras³

et al. 2019

AJBSR

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“…In a study evaluating embryo quality, Kavoussi et al [ 38 ] reported that regardless of age, low serum AMH levels (<1 ng/mL) were associated with a significantly lower availability of high-quality blastocysts for cryopreservation than was observed in patients with higher AMH levels (1–4 ng/mL) in IVF cycles.…”

Section: Ovarian Reserve Markersmentioning

confidence: 99%

The meaning of anti-Müllerian hormone levels in patients at a high risk of poor ovarian response

Park

Lee

Gong

et al. 2016

Clin Exp Reprod Med

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Measurements of ovarian reserve play an important role in predicting the clinical results of assisted reproductive technology (ART). The ideal markers of ovarian reserve for clinical applications should have high specificity in order to determine genuine poor responders. Basal follicle-stimulating hormone levels, antral follicle count, and serum anti-Müllerian hormone (AMH) levels have been suggested as ovarian reserve tests that may fulfill this requirement, with serum AMH levels being the most promising parameter. Serum AMH levels have been suggested to be a predictor of clinical pregnancy in ART for older women, who are at a high risk for decreased ovarian response. We reviewed the prognostic significance of ovarian reserve tests for patients undergoing ART treatment, with a particular focus on the significance of serum AMH levels in patients at a high risk of poor ovarian response.

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Antimüllerian hormone as a predictor of good-quality supernumerary blastocyst cryopreservation among women with levels <1 ng/mL versus 1–4 ng/mL

Cited by 16 publications

References 24 publications

Prediction of metaphase II oocytes according to different serum Anti-Müllerian hormone (AMH) levels in antagonist ICSI cycles

Prediction of metaphase II oocytes according to different serum Anti-Müllerian hormone (AMH) levels in antagonist ICSI cycles

Lack of Predictive Value of Ovarian Reserve Tests for Pregnancy Likelihood. The Huge Difference Between Quantity and Quality

The meaning of anti-Müllerian hormone levels in patients at a high risk of poor ovarian response

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