Antimullerian hormone (AMH) level and IVF/ICSI cycle outcome in expected poor responders

Alanazi, Hanan; Bushaqer, Nayla; Ayyoub, Hisham A.; Dayoub, Nawal; Hassan, Samar

doi:10.1016/j.mefs.2017.10.007

Cited by 9 publications

(6 citation statements)

References 34 publications

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“…Concerning the prediction of POR, we found that AMH has a higher sensitivity and specificity than FSH and AFC together (Baker et al, 2018), although other authors reported that AFC and AMH have a similar correlation for the prediction of POR (Alanazi et al, 2018), as well as higher FSH levels, which have a correlation with low AMH concentrations with POR.…”

Section: Discussioncontrasting

confidence: 61%

Correlation between biochemical, ultrasonographic and demographic parameters with ovarian response to IVF/ICSI treatments in Mexican women

Vazquez¹,

Rodríguez²,

Algara³

et al. 2020

JBRA Assisted Reproduction

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Objective: Ovarian response from a conventional ovarian stimulation protocol is a crucial step in IVF/ICSI treatments. This ovarian response encompasses a wide range of outcomes at the extremes, leading to either excessive responses with the risk of life-threatening conditions like ovarian hyperstimulation syndrome (OHSS), or poor ovarian response (POR) with poor outcomes. This study aims to integrate biochemical, ultrasonographic and demographic parameters into a mathematical formula able to predict ovarian response to stimulation in IVF/ICSI in gonadotropin-releasing hormone (GnRH) antagonist protocols. Methods: This retrospective analysis included 147 patients submitted to an ovarian stimulation protocol combining recombinant FSH and gonadotropin-releasing hormone antagonist. All the parameters were correlated with the Spearman Rho and Pearson´s correlation coefficient. Once the data was normalized, we used the multiple linear regression models, checking the results with the progressive discriminating analysis. Results: We classified the database according to the correlation with the number of oocytes retrieved; the progressive discriminating analysis resulted in the following equation: oocytes retrieved = 2.312-0.130 (FSH) + 0.562 (AFC). Conclusions: The incorporation of 2 ovarian reserve parameters into a regression equation enables knowing the number of retrieved oocytes in each patient with 80.5% sensitivity and 55.4% specificity.

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Section: Discussioncontrasting

confidence: 61%

Correlation between biochemical, ultrasonographic and demographic parameters with ovarian response to IVF/ICSI treatments in Mexican women

Vazquez¹,

Rodríguez²,

Algara³

et al. 2020

JBRA Assisted Reproduction

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show abstract

“…The probability of dispermy might be excluded since the records of the IVF procedure under the microscope did not reveal any sign of the incident. It has been shown that AMH levels are associated with the implantation rates following ART procedures [10,11]. In our series, we observed that the AMH levels and the total number of collected oocytes in the cycle were significantly lower in the chromosomal abnormality group.…”

Section: Discussionsupporting

confidence: 49%

Cytogenetic analysis of early pregnancy loss after assisted reproduction treatment using intracytoplasmic sperm injection

et al. 2021

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“…Also, Hanan El Anazi and her coworkers studied 258 women who had a poor ovarian response and found that AMH predicted a lower number of pregnancies in the cohort of women studied. In women above 35 years, we expect a considerable percentage of those women to be poor responders [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

FSH versus AMH: age-related relevance to ICSI results

Salama

Sharaf

Salem

et al. 2021

Middle East Fertil Soc J

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Background Women’s fecundity is known to decrease with the increase in chronologic age. Several biomarkers of the ovarian reserve, including follicle stimulating hormone (FSH), anti Müllerian hormone (AMH), have been proposed as possible predictors for the response to controlled ovarian stimulation (COS). Although there are assumptions indicating that the relationship between age and ovarian reserve is highly variable and the potential different validity of ovarian reserve markers in women in different age groups remains to be demonstrated. The purpose of our study was evaluating FSH and AMH as potential predictors of response to controlled ovarian stimulation and prediction of intracytoplasmic sperm injection (ICSI) outcome according to age. This prospective study has been carried out on 218 women having ICSI cycles. Cases were divided into two groups, group 1 (n 148), their age < 35 years, and group 2 (n 70), their age ≥ 35 years. All women received antagonist protocol during their ICSI cycles. Basal FSH and AMH were measured and correlated to the number of follicles on the day of trigger, the number of oocytes retrieved, chemical, and clinical pregnancies. Results The fertilization rate in group 1 was 68.15%, while in group 2 was 77.82% (p = 0.003) while the implantation rate (number of gestational sacs observed at 6 weeks of pregnancy divided by the number of transferred embryos) was 18.95 and 11.98% in group 1 and group 2, respectively (p = 0.041). The clinical pregnancy rate among both groups was 38.51% in group 1, while 24.29% in group 2 (p = 0.038). Women who got pregnant among those aged < 35 years had significantly lower basal FSH (p < 0.001), while women who got pregnant among those aged ≥ 35 years had significantly higher AMH levels (p value < 0.001) and higher E2 levels on the day of trigger (p = 0.007). Conclusion We found that below the age of 35 years, the chances of pregnancy are more correlated to FSH levels, while above the age of 35 years, AMH was a more relevant test.

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Antimullerian hormone (AMH) level and IVF/ICSI cycle outcome in expected poor responders

Cited by 9 publications

References 34 publications

Correlation between biochemical, ultrasonographic and demographic parameters with ovarian response to IVF/ICSI treatments in Mexican women

Correlation between biochemical, ultrasonographic and demographic parameters with ovarian response to IVF/ICSI treatments in Mexican women

Cytogenetic analysis of early pregnancy loss after assisted reproduction treatment using intracytoplasmic sperm injection

FSH versus AMH: age-related relevance to ICSI results

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