Antimony in Medical History: An Account of the Medical Uses of Antimony and Its Compounds since Early Times to the Present (review)

Debus, Allen G.

doi:10.1353/bhm.2000.0064

Cited by 7 publications

(5 citation statements)

References 1 publication

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“…This was reported earlier. 40 The weight of epididymides, seminal vesicle and prostate glands were reduced significantly (p ≤ 0.001), which may be due to the absence of sperm in the lumen of epididymides tubules. The epididymides provides a suitable environment for morphological and biochemical changes in the spermatozoa under the influence of androgen.…”

Section: Discussionmentioning

confidence: 93%

Antifertility and antimicrobial studies of pharmaceutically important organolead(IV) complexes of phenanthrolines

Chaudhary

Mahajan

Singh

2006

Applied Organom Chemis

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The present study deals with a brief description of antifertility and antimicrobial aspects along with the spectral characterization of lead(IV) complexes. The testicular sperm density, testicular sperm morphology, sperm motility, density of cauda epididymal spermatozoa and fertility in mating trails and biochemical parameters of reproductive organs of an interesting class of biologically potent complexes on male albino rats at the dosages have been examined and discussed. Lead(IV) complexes have been synthesized using amino acids and 1,10-phenanthroline, 4,7-phenanthroline or 1,7-phenanthroline. A series of di-and tri-organolead(IV) [LPbR n L ] and [LPbClR n L ] complexes where, L = amino acid (tyrosine and phenylalanine) and L = 1, 10-phenanthroline, 4,7-phenanthroline or 1,7-phenanthroline and n = 2 or 3 have been prepared by the conventional methods. Structure elucidation has been done by IR, UV, 1 H, 13 C and 207 Pb NMR spectroscopy. On the basis of spectral evidences, it has been concluded that the carboxylic acid of the amino acid is behaving as a monodentate ligand in all these complexes and the complexes are octahedral in shape with a coordination number six around the lead atom. The complexes have been screened against a number of fungi and bacteria to assess their growth inhibiting potential. Lead complexes incorporating the chelating 1,10-phenanthroline ligand showed a range of activities. The metal free non-chelating ligands 1,7-phenanthroline and 4,7-phenanthroline were inactive and the complexes derived from 1,7-phenanthroline displayed only marginal activity.

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Section: Discussionmentioning

confidence: 93%

Antifertility and antimicrobial studies of pharmaceutically important organolead(IV) complexes of phenanthrolines

Chaudhary

Mahajan

Singh

2006

Applied Organom Chemis

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“…Antimony had quite widespread use in pharmacology for the treatment of syphilis, fever, melancholy, pneumonia, epilepsy, and inflammatory conditions 14 . Organic antimony salts are used medically to treat some tropical diseases 15 , especially in the treatment of all forms of leishmenasis 16 .…”

Section: Introductionmentioning

confidence: 99%

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2014

IJPSR

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Some new Sb(III) and As(III) complexes of N∩S donor ligands N'-[1-(2-oxo-2H-chrome-3yl-ethylidene] -hydrazinecarbodithionic acid methyl ester (L1H) and N' -[1-(2-oxo-2H-chrome-3yl -ethylidene] -hydrazinecarbodithionic acid benzyl ester (L2H) have been synthesized. All the synthesized compounds were characterized by elemental analyses, melting point determinations and a combination of electronic, IR, 1H NMR, and X-ray diffraction spectroscopic techniques. These studies showed that the ligands coordinated to organoantimony and organoarsenic in a monobasic bidentate manner through sulfur and nitrogen donor system. Thus, tetra and pentacoordinated environments around the antimony and arsenic atom have been proposed. In order to evaluate the effect of metal ions upon chelation, both the ligands and their complexes have been screened for their antimicrobial activity against the various pathogenic bacterial and fungal strains. The results indicate that the metal complexes are more potent antimicrobial agents than the parent ligands. Further, the ligands and their corresponding metal complexes have been tested for their pesticidal activity against the Corcyra cephalonica. The results of pesticidal screening are quite promising.

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“…15 Antimony(III) complexes are very interesting due to their fascinating structures, bonding variations, 16,17 and potential applicability as biocides. [18][19][20] Organic antimony salts are used medically to treat some tropical diseases, 21 especially in the treatment of all forms of leishmenasis. 22 Among the antimony derivatives containing nitrogen and oxygen/sulfur donor sites, their thiosemicarbazone and semicarbazone derivatives have been studied extensively from their analytical points of view and biological applications.…”

Section: Introductionmentioning

confidence: 99%

Microwave-Assisted Synthesis, and Stereochemical and Biological Aspects of Some Antimony(III) and Bismuth(III) Complexes with Biologically Potent Bidentate Schiff Bases

Mahajan

Swami

Singh

2009

Phosphorus, Sulfur, and Silicon and the Related Elements

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Antimony in Medical History: An Account of the Medical Uses of Antimony and Its Compounds since Early Times to the Present (review)

Cited by 7 publications

References 1 publication

Antifertility and antimicrobial studies of pharmaceutically important organolead(IV) complexes of phenanthrolines

Antifertility and antimicrobial studies of pharmaceutically important organolead(IV) complexes of phenanthrolines

Untitled

Microwave-Assisted Synthesis, and Stereochemical and Biological Aspects of Some Antimony(III) and Bismuth(III) Complexes with Biologically Potent Bidentate Schiff Bases

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