Antimicrobic and hemolytic activity of low-molecular metabolits of brown seaweed Laminaria cichorioides (Miyabe)

Gerasimenko, N. I.; Chaykina, E. L.; Busarova, N. G.; Anisimov, M. M.

doi:10.1134/s0003683810040113

Cited by 13 publications

(13 citation statements)

References 26 publications

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“…It is important to note that FAs (and in particular, the unsaturated FAs) extracted from other marine organisms, such as algae (Ikawa 2004), dinoflagellates (Dorantes-Aranda et al 2009), seaweed (Gerasimenko et al 2010) and fish (Mancini et al 2011), have important cytotoxic roles in interactions with predators in aquatic ecosystems (Wu et al 2006;Núñez-Pons and Avila 2014). According to the present GC-MS/FID analysis, there were high contents of C18:1 in the extracts from L. bocagei 11172 and 11255 (Table 4).…”

Section: Discussionmentioning

confidence: 78%

Fatty acid composition and antioxidant activity of Antarctic marine sponges of the genus Latrunculia

et al. 2015

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The fatty acid composition of marine cold-water sponges of genus Latrunculia, namely Latrunculia bocagei Ridley and Dendy, 1886, and Latrunculia biformis Kirkpatrick, 1907, for which no fatty acid data had been previously reported, has been examined. High levels of longchain fatty acids (C 24-30 ) with high unsaturation levels (mainly polyunsaturation), and high incidence of branchedand odd-chain fatty acids in sponges are suggested to be partially connected with their specific cell membrane requirements to surmount the negative effects of low temperatures and to enable growth in extreme environments. Furthermore, variations in the fatty acid profile at the species level may reflect variations in compositions or quantities of symbiotic microorganisms that commonly represent up to 60 % of the sponge wet weight. The fatty acid compositions of lipid-rich sponge extracts from five Latrunculia specimens dredged from the Bransfield Strait near the Antarctic Peninsula, were obtained using supercritical carbon dioxide and analyzed using gas chromatography-mass spectrometry-flame ionization detection. Furthermore, the antioxidant activities of these extracts were determined using the photochemiluminescent method. Along with common fatty acids, the chemical analyses revealed very long-chain fatty acids (C22, C24). Differences were seen for the fatty acid levels between both species and different specimens of the same species. The observed differences do not seem connected to the habitat depth of the specimen, but rather indicate the variations within the associated microbiome. Furthermore, these sponge extracts showed antioxidant activities, confirming that they contain lipidic compounds that strongly scavenge free radicals.

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Section: Discussionmentioning

confidence: 78%

Fatty acid composition and antioxidant activity of Antarctic marine sponges of the genus Latrunculia

et al. 2015

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“…The hemolytic activity of the equimolar mixture of linoleic, oleic, and palmitic acids is indeed comparable with the activity of the W. sebi extract and is associated with the unsaturated fatty acids. It has already been reported that fatty acids extracted from marine fungi and from other marine organisms, such as algae (Ikawa, ), dinoflagellates (Dorantes‐Aranda et al ., ), seaweed (Gerasimenko et al ., ), and fish (Mancini et al ., ), have a role in the lysis of erythrocytes. Among nine fatty acids that were tested, the α‐linoleic (C18:3), linoleic (C18:2), and oleic (C18:1) acids were the most potent algal growth inhibitors, as they can cause deleterious damage to the plasma membrane (Wu et al ., ).…”

Section: Discussionmentioning

confidence: 99%

Salt induces biosynthesis of hemolytically active compounds in the xerotolerant food-borne fungus Wallemia sebi

Botić

Kunčič

Sepčić

et al. 2011

FEMS Microbiol Lett

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Wallemia sebi is a xerotolerant, ubiquitous, food-borne, mycotoxigenic fungus. An ethanol extract of its mycelium demonstrated a strong hemolytic activity, which was further enhanced at high salt concentrations in the growth medium. Characterization of the extract using gas chromatography-mass spectrometry revealed a mixture of sterols and unsaturated fatty acids, indicating the latter as responsible for the hemolytic activity. The lytic activity of the extract is here studied using red blood cells and artificial small lipid vesicles with various lipid compositions. This shows concentration-dependent hemolysis and preferential activity toward lipid membranes with greater fluidity. The W. sebi lytic activity on mammalian erythrocytes shows its potential involvement in the formation of lesions in subcutaneous infections, in farmer's lung disease, and in consumption of food and feed that are contaminated with food-borne W. sebi.

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“…SQDG fractions from S. vulgare with antiviral activity (HSV-1 and HSV-2), displayed CC 50 > 200 µg/mL in Vero cells [119]. The ethanolic extract as well as the glycolipid, FA and pigments' fractions from L. cichorioides demonstrated hemolytic activity at 200 µg/mL in erythrocytes of mongrel white mice [91]. SQDG(16:0/16:0) isolated from C. racemosa with antiviral activity (HSV-2) had very low toxicity to Vero cells ATCC CCL-81 with a CC 50 of 1.0 g/mL [95].…”

Section: Cytotoxicity Of Natural Antimicrobial Lipids Against Mammalimentioning

confidence: 98%

“…Several studies demonstrated higher antimicrobial activity in lipid-rich fractions than in total lipid extracts [91,118]. In the brown seaweed S. pallidum, the isolated fractions of glycolipids and free FA demonstrated to be more efficient in inhibiting bacterial growth than the total lipid extract [118].…”

Section: Glycolipidsmentioning

confidence: 99%

“…The most dominant pathogens that harm global crop production belong to the genera Alternaria and Fusarium [207]. Enriched fractions of glycolipids from the macroalgae L. cichorioides and S. pallidum, as well as free FA and PUFA fractions from L. cichorioides, and FA esters, triacylgycerols/free sterols, free sterols and diacylglycerol fractions from S. pallidum demonstrated activity against the fungus F. oxysporum [91,118]. Lipid fractions with several steroid compounds from the oyster S. glomerata were very active against Fusarium sp.…”

Section: Herbicides and Pesticidesmentioning

confidence: 99%

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Antimicrobial Lipids from Plants and Marine Organisms: An Overview of the Current State-of-the-Art and Future Prospects

et al. 2020

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In the actual post-antibiotic era, novel ways of rethinking antimicrobial research approaches are more urgent than ever. Natural compounds with antimicrobial activity such as fatty acids and monoacylglycerols have been investigated for decades. Additionally, the interest in other lipid classes as antimicrobial agents is rising. This review provides an overview on the research about plant and marine lipids with potential antimicrobial activity, the methods for obtaining and analyzing these compounds, with emphasis on lipidomics, and future perspectives for bioprospection and applications for antimicrobial lipids. Lipid extracts or lipids isolated from higher plants, algae or marine invertebrates are promising molecules to inactivate a wide spectrum of microorganisms. These lipids include a variety of chemical structures. Present and future challenges in the research of antimicrobial lipids from natural origin are related to the investment and optimization of the analytical workflow based on lipidomics tools, complementary to the bioassay-guided fractionation, to identify the active compound(s). Also, further work is needed regarding the study of their mechanism of action, the structure–activity relationship, the synergistic effect with conventional antibiotics, and the eventual development of resistance to lipids, which, as far as is known, is unlikely.

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Antimicrobic and hemolytic activity of low-molecular metabolits of brown seaweed Laminaria cichorioides (Miyabe)

Cited by 13 publications

References 26 publications

Fatty acid composition and antioxidant activity of Antarctic marine sponges of the genus Latrunculia

Fatty acid composition and antioxidant activity of Antarctic marine sponges of the genus Latrunculia

Salt induces biosynthesis of hemolytically active compounds in the xerotolerant food-borne fungus Wallemia sebi

Antimicrobial Lipids from Plants and Marine Organisms: An Overview of the Current State-of-the-Art and Future Prospects

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