Antimicrobials offered from nature: Peroxidase-catalyzed systems and their mimics

Tonoyan, Lilit; Montagner, Diego; Friel, Ruairi; O’Flaherty, Vincent

doi:10.1016/j.bcp.2020.114281

Cited by 20 publications

(12 citation statements)

References 86 publications

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“…However, conventional antibiofilm agents' poor water-solubility and biofilm penetration often limit their therapeutic efficacy. [15,16] Therefore, developing an alternative, non-antibiotic treatment for oral biofilms is highly desired.In nature, enzymes are widely involved in immune systems to eradicate the invading microbes, [17] and the peroxidase-like Developing nature-inspired nanomaterials with enzymatic activity is essential in combating bacterial biofilms. Here, it is reported that incorporating the carboxylic acid in phenolic/Fe nano-networks can efficiently manipulate their peroxidase-like activity via the acidic microenvironment and neighboring effect of the carboxyl group.…”

mentioning

confidence: 99%

“…In nature, enzymes are widely involved in immune systems to eradicate the invading microbes, [17] and the peroxidase-like Developing nature-inspired nanomaterials with enzymatic activity is essential in combating bacterial biofilms. Here, it is reported that incorporating the carboxylic acid in phenolic/Fe nano-networks can efficiently manipulate their peroxidase-like activity via the acidic microenvironment and neighboring effect of the carboxyl group.…”

mentioning

confidence: 99%

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Neighboring Carboxylic Acid Boosts Peroxidase‐Like Property of Metal‐Phenolic Nano‐Networks in Eradicating Streptococcus mutans Biofilms

Wang

Zhou

et al. 2022

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Developing nature‐inspired nanomaterials with enzymatic activity is essential in combating bacterial biofilms. Here, it is reported that incorporating the carboxylic acid in phenolic/Fe nano‐networks can efficiently manipulate their peroxidase‐like activity via the acidic microenvironment and neighboring effect of the carboxyl group. The optimal gallic acid/Fe (GA/Fe) nano‐networks demonstrate highly enzymatic activity in catalyzing H2O2 into oxidative radicals, damaging the cell membrane and extracellular DNA in Streptococcus mutans biofilms. Theoretical calculation suggests that the neighboring carboxyl group can aid the H2O2 adsorption, free radical generation, and catalyst reactivation, resulting in superb catalytic efficiency. Further all‐atom simulation suggests the peroxidation of lipids can increase the cell membrane fluidity and permeability. Also, GA/Fe nano‐networks show great potential in inhibiting tooth decay and treating other biofilm‐associated diseases without affecting the commensal oral flora. This strategy provides a facile and scale‐up way to prepare the enzyme‐like materials and manipulate their enzymatic activity for biomedical applications.

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confidence: 99%

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confidence: 99%

Neighboring Carboxylic Acid Boosts Peroxidase‐Like Property of Metal‐Phenolic Nano‐Networks in Eradicating Streptococcus mutans Biofilms

Wang

Zhou

et al. 2022

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“…Although the affinity of this enzyme for iodides is higher due to low concentrations in the blood, its role in protection is insignificant. However, if the concentration of iodides in the blood is increased, this effect will noticeably increase [18]. The reaction proceeds according to the scheme: (H 2 O 2 + I − → OI − + H 2 O).…”

Section: Resultsmentioning

confidence: 99%

The efficacy of combination the amoxicillin and new complex of iodine for lungs infection of mice caused by Klebsiella pneumonia

Islamov¹,

Поминова

Myrzabayeva

et al. 2021

ijbch

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In this work, the effectiveness of combination therapy of a new iodine complex (PA) and amoxicillin was investigated. For this, an experimental model of mouse lung infection caused by multiresistant Klebsiella pneumonia ATCC 700603 strain was used. Therapy was administered for 14 days with amoxicillin at a dose of 10 mg/kg and PA at doses of 20 and 200 mg/kg. In addition, the post-therapeutic effect was assessed on day 7. The level of bacteria was studied in the lungs and blood. The concentration of antibiotic and PA in blood was also measured. As a result, it was found that on day 14 the level of bacteria in the lungs and blood significantly decreased with a combination of 10 mg/kg amoxicillin and 200 mg/ kg PA. 7 days after the completion of therapy, complete elimination of bacteria occurred in the groups of 20 and 200 mg/kg PA in combination with an antibiotic. With the combined effect of PA and amoxcillin, the level of the antibiotic increases, this may indicate an improvement in bioavailability. These results demonstrate the effectiveness of PA in combination with amoxicillin.

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“…It has been reported that the natural pH value of the skin is slightly acidic, and in the acute wound stage it is between pH 4 and 6. , Based on this, nanozymes, a kind of nanomaterial that can maintain enzyme catalytic performance and stimulate natural enzymes to generate toxic reactive oxygen species (ROS) for sterilization, were studied . Nanozymes with peroxidase (POD)-like activity (such as TA-Ag, Co 3 O 4 , Fe 2 (MoO 4 ) 3 , , and 2D Co-MOF) could convert exogenous H 2 O 2 into highly noxious hydroxyl radicals ( • OH) for the treatment of bacterial infections. − However, in the actual application of wound sterilization, the addition of exogenous H 2 O 2 will inevitably cause secondary pain to the infected tissue. Moreover, the added H 2 O 2 is easy to decompose, and the additional amount is not easy to control, which is very troublesome in the actual application process.…”

Section: Introductionmentioning

confidence: 99%

Application of a Cascaded Nanozyme in Infected Wound Recovery of Diabetic Mice

Zhang

et al. 2022

ACS Biomater. Sci. Eng.

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The emergence of peroxidase (POD)-like nanozyme-derived catalytic therapy has provided a promising choice for reactive oxygen species (ROS)-mediated broad-spectrum antibacterials to replace antibiotics, but it still suffers from limitations of low therapeutic efficiency and unusual addition of unstable H2O2. Considering that the higher blood glucose in diabetic wounds provides much more numerous nutrients for bacterial growth, a cascade nanoenzymatic active material was developed by coating glucose oxidase (GOx) onto POD-like Fe2(MoO4)3 [Fe2(MoO4)3@GOx]. GOx could consume the nutrient of glucose to produce gluconic acid (weakly acidic) and H2O2, which could be subsequently converted into highly oxidative •OH via the catalysis of POD-like Fe2(MoO4)3. Accordingly, the synergistic effect of starvation and ROS-mediated therapy showed significantly efficient antibacterial effect while avoiding the external addition of H2O2 that affects the stability and efficacy of the therapy system. Compared with the bactericidal rates of 46.2–59.404% of GOx or Fe2(MoO4)3 alone on extended-spectrum β-lactamases producing Escherichia coli and methicillin-resistant Staphylococcus aureus, those of the Fe2(MoO4)3@GOx group are 98.396 and 98.776%, respectively. Animal experiments showed that the as-synthesized Fe2(MoO4)3@GOx could much efficiently promote the recovery of infected wounds in type 2 diabetic mice while showing low cytotoxicity in vivo.

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Antimicrobials offered from nature: Peroxidase-catalyzed systems and their mimics

Cited by 20 publications

References 86 publications

Neighboring Carboxylic Acid Boosts Peroxidase‐Like Property of Metal‐Phenolic Nano‐Networks in Eradicating Streptococcus mutans Biofilms

Neighboring Carboxylic Acid Boosts Peroxidase‐Like Property of Metal‐Phenolic Nano‐Networks in Eradicating Streptococcus mutans Biofilms

The efficacy of combination the amoxicillin and new complex of iodine for lungs infection of mice caused by Klebsiella pneumonia

Application of a Cascaded Nanozyme in Infected Wound Recovery of Diabetic Mice

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