Antimicrobials in urogenital infections

Wagenlehner, Florian M. E.; Wullt, Björn; Perletti, Gianpaolo

doi:10.1016/j.ijantimicag.2011.09.004

Cited by 40 publications

(44 citation statements)

References 83 publications

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“…Tigecycline and aminoglycosides are treatment options; however, tigecycline has low plasma and urinary levels and aminoglycosides have significant adverse effects. Moreover, resistance to these antibiotics has increased (4)(5)(6).…”

mentioning

confidence: 99%

Susceptibility of Multiresistant Gram-Negative Bacteria to Fosfomycin and Performance of Different Susceptibility Testing Methods

Neto

Oliveira

Rizek

et al. 2014

Antimicrob Agents Chemother

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Fosfomycin may be a treatment option for multiresistant Gram-negative bacteria. This study compared susceptibility methods using 94 multiresistant clinical isolates. With agar dilution (AD), susceptibilities were 81%, 7%, 96%, and 100% (CLSI) and 0%, 0%, 96%, and 30% (EUCAST), respectively, for Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Enterobacter spp. Categorical agreement between Etest and AD for Enterobacteriaceae and A. baumannii was >80%. Disk diffusion was adequate only for Enterobacter. CLSI criteria for urine may be adequate for systemic infections.

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mentioning

confidence: 99%

Susceptibility of Multiresistant Gram-Negative Bacteria to Fosfomycin and Performance of Different Susceptibility Testing Methods

Neto

Oliveira

Rizek

et al. 2014

Antimicrob Agents Chemother

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“…C. trachomatis serovars A to C are involved in trachoma pathogenesis and serovars D to K induce pelvic inflammatory diseases (PIDs), infertility, and reactive arthritis, while the LGV serovars are the pathogens that cause lymphogranuloma venereum, a sexually transmitted disease with systemic manifestations. The antibiotics used for therapy of chlamydia infections include tetracyclines and macrolides (3)(4)(5). While antibiotic therapy is effective in the majority of cases, tetracycline and azithromycin resistance has been reported (6,7).…”

mentioning

confidence: 99%

Application of DNA Chip Scanning Technology for Automatic Detection of Chlamydia trachomatis and Chlamydia pneumoniae Inclusions

Bogdanov

Endrész

Urbán

et al. 2014

Antimicrob Agents Chemother

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e Chlamydiae are obligate intracellular bacteria that propagate in the inclusion, a specific niche inside the host cell. The standard method for counting chlamydiae is immunofluorescent staining and manual counting of chlamydial inclusions. High-or medium-throughput estimation of the reduction in chlamydial inclusions should be the basis of testing antichlamydial compounds and other drugs that positively or negatively influence chlamydial growth, yet low-throughput manual counting is the common approach. To overcome the time-consuming and subjective manual counting, we developed an automatic inclusion-counting system based on a commercially available DNA chip scanner. Fluorescently labeled inclusions are detected by the scanner, and the image is processed by ChlamyCount, a custom plug-in of the ImageJ software environment. ChlamyCount was able to measure the inclusion counts over a 1-log-unit dynamic range with a high correlation to the theoretical counts. ChlamyCount was capable of accurately determining the MICs of the novel antimicrobial compound PCC00213 and the already known antichlamydial antibiotics moxifloxacin and tetracycline. ChlamyCount was also able to measure the chlamydial growth-altering effect of drugs that influence host-bacterium interaction, such as gamma interferon, DEAE-dextran, and cycloheximide. ChlamyCount is an easily adaptable system for testing antichlamydial antimicrobials and other compounds that influence Chlamydia-host interactions.

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“…45% of the drug is excreted in the urine and has high activity against uropathogens, particularly E.coli and other Enterobacteriaceae, although it is not very active against Gram positive cocci, cure rates of S. saprohyticus infection were 73-89% [243][244][245].…”

Section: National Ambulatory Antibiotic Consumption Studymentioning

confidence: 99%

“…On the other hand the use of fosfomycin in complicated cystitis/pyelonephritis is not satisfactory due to the lack of activity against Gramnegative pathogens other than E. coli [263], therefore the recorded fosfomycin use should be regarded inappropriate in these cases. The low perscription rate for nitrofurantoin in uncomplicated cystitis was not surprising as national guideline emphasize its low eradication rate [183].…”

Section: Other Antibacterialsmentioning

confidence: 99%

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Evaluation of the Hungarian ambulatory antibacterial use in urinary tract infections with different methods

Juhász¹

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Antimicrobials in urogenital infections

Cited by 40 publications

References 83 publications

Susceptibility of Multiresistant Gram-Negative Bacteria to Fosfomycin and Performance of Different Susceptibility Testing Methods

Susceptibility of Multiresistant Gram-Negative Bacteria to Fosfomycin and Performance of Different Susceptibility Testing Methods

Application of DNA Chip Scanning Technology for Automatic Detection of Chlamydia trachomatis and Chlamydia pneumoniae Inclusions

Evaluation of the Hungarian ambulatory antibacterial use in urinary tract infections with different methods

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