Antimicrobial Use in Animal Food Production

Garvey, Mary

doi:10.1007/978-3-031-07434-9_6

Cited by 1 publication

(3 citation statements)

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“…For the treatment of C. perfringens sepsis and septic shock, penicillin G and clindamycin, tetracycline, or metronidazole in combination with surgical removal may prevent patient mortality [25]. Antibiotics such as streptothricin, streptomycin, tetracycline and sulfapyridine have been used as growth promotors in chicken and pig feed, leading to increased productivity [77]. This application of antibiotics in food-producing animals and in animal feed has encouraged the emergence of MDR strains of C. perfringens [32].…”

Section: Antibiotic Treament Of Clostridioides Speciesmentioning

confidence: 99%

“…Controlling infectious disease via the stringent application of biocides is effective in preventing nosocomial and foodborne transmission of pathogenic species; such chemicals, however, are also prone to AMR and are not biocompatible [34]. Novel biocontrol options offering a green alternative include antimicrobial peptides and bacteriophages [77]. In line with One Health, eliminating pathogens including Clostridioides from food production environments, and reducing the incidence of animal disease will prevent human disease outbreak and contribute to food sustainability [80].…”

Section: Biocontrol Agents In the Mitigation Of Clostridioidesmentioning

confidence: 99%

“…Having either single-or double-stranded DNA or RNA in a protein capsid, phages are abundant in nature. As potent antibacterial agents, phages and phage-derived enzymes termed endolysins have potential as biocontrol agents in food production, as summarised elsewhere [77,95,96]. The International Committee for Taxonomy of Viruses (ICTV) classifies nineteen phage families, with families Myoviridae and Siphoviridae phages of C. difficile [96].…”

Section: Bacteriophages Against Foodborne Clostridioidesmentioning

confidence: 99%

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Foodborne Clostridioides Species: Pathogenicity, Virulence and Biocontrol Options

Garvey

2023

Microorganisms

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Clostridioides species possess many virulence factors and alarming levels of muti-drug resistance which make them a significant risk to public health safety and a causative agent of livestock disease. Clostridioides result in serious systemic and gastrointestinal diseases such as myonecrosis, colitis, food poisoning and gastroenteritis. As foodborne pathogens, Clostridioides species are associated with significant incidences of morbidity and mortality where the application of broad-spectrum antibiotics predisposes patients to virulent Clostridioides colonisation. As part of the One Health approach, there is an urgent need to eliminate the use of antibiotics in food production to safeguard animals, humans and the environment. Alternative options are warranted to control foodborne pathogens at all stages of food production. Antimicrobial peptides and bacteriophages have demonstrated efficacy against Clostridioides species and may offer antimicrobial biocontrol options. The bacteriocin nisin, for example, has been implemented as a biopreservative for the control of Listeria, Staphylococcus and Clostridia species in food. Bacteriophage preparations have also gained recognition for the antibacterial action against highly virulent bacterial species including foodborne pathogens. Studies are warranted to mitigate the formulation and administration limitations associated with the application of such antimicrobials as biocontrol strategies. This review outlines foodborne Clostridioides species, their virulence factors, and potential biocontrol options for application in food production.

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Section: Antibiotic Treament Of Clostridioides Speciesmentioning

confidence: 99%