Antimicrobial treatment of Capnocytophaga infections

Jolivet‐Gougeon, Anne; Sixou, Jean-Louis; Tamanai-Shacoori, Zohreh; Bonnaure‐Mallet, Martine

doi:10.1016/j.ijantimicag.2006.10.005

Cited by 114 publications

(95 citation statements)

References 64 publications

(166 reference statements)

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“…Capnocytophaga spp. are Gram-negative, microaerophilic, and CO 2 -requiring found in the oropharyngeal tract of mammals and cause infections in animal bite wounds as well as periodontal diseases (Jolivet-Gougeon et al 2007). (e) Extremophiles: Many, if not all, of these organisms (Supplementary Material 2) live in various degrees of extreme habitats and often derive energy from the reduction of exotic substrates.…”

Section: Dfi Genes Occur In Select Microorganisms Onlymentioning

confidence: 99%

On the role, ecology, phylogeny, and structure of dual-family immunophilins

Barik¹

2017

Cell Stress and Chaperones

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The novel class of dual-family immunophilins (henceforth abbreviated as DFI) represents naturally occurring chimera of classical FK506-binding protein (FKBP) and cyclophilin (CYN), connected by a flexible linker that may include a three-unit tetratricopeptide (TPR) repeat. Here, I report a comprehensive analysis of all current DFI sequences and their host organisms. DFIs are of two kinds: CFBP (cyclosporin-and FK506-binding protein) and FCBP (FK506-and cyclosporin-binding protein), found in eukaryotes. The CFBP type occurs in select bacteria that are mostly extremophiles, such as psychrophilic, thermophilic, halophilic, and sulfur-reducing. Essentially all DFI organisms are unicellular. I suggest that DFIs are specialized bifunctional chaperones that use their flexible interdomain linker to associate with large polypeptides or multisubunit megacomplexes to promote simultaneous folding or renaturation of two clients in proximity, essential in stressful and denaturing environments. Analysis of sequence homology and predicted 3D structures of the FKBP and CYN domains as well as the TPR linkers upheld the modular nature of the DFIs and revealed the uniqueness of their TPR domain. The CFBP and FCBP genes appear to have evolved in parallel pathways with no obvious single common ancestor. The occurrence of both types of DFI in multiple unrelated phylogenetic clades supported their selection in metabolic and environmental niche roles rather than a traditional taxonomic relationship.Nonetheless, organisms with these rare immunophilins may define an operational taxonomic unit (OTU) bound by the commonality of chaperone function.

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Section: Dfi Genes Occur In Select Microorganisms Onlymentioning

confidence: 99%

On the role, ecology, phylogeny, and structure of dual-family immunophilins

Barik¹

2017

Cell Stress and Chaperones

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“…Generally, however, C canimorsus is susceptible to most antibiotics, excluding aztreonam, trimotheprim-sulfamethoxazole, and aminoglycosides [15,17]. Capnocytophaga spp are reportedly universally susceptible to carbapenems such as imipenem [1].…”

Section: Discussionmentioning

confidence: 99%

Case Report: Capnocytophaga canimorsus A Novel Pathogen for Joint Arthroplasty

Larson

Razonable

Hanssen

2008

Clin Orthop Relat Res

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“…Capnocytophaga species are part of the normal oral flora in dogs, cats, and humans and were once associated with periodontal disease but are now considered commensals in dental plaque of humans (10). In immunocompetent patients, respiratory tract infections occur due to secretions from the oral cavity and are usually polymicrobial (5,17).…”

Section: Case Reportmentioning

confidence: 99%

“…In immunocompetent patients, respiratory tract infections occur due to secretions from the oral cavity and are usually polymicrobial (5,17). In immunocompromised hosts with neutropenia or oral ulcerations, Capnocytophaga species can cause severe systemic infections and even death (10,17).…”

Section: Case Reportmentioning

confidence: 99%

“…Capnocytophaga infections can have varied clinical presentations, such as periodontal disease (9,22), respiratory tract infections (3), ophthalmic lesions (1,6,18), traumatic pericarditis, mediastinal abscess (16), brain abscess (21), meningitis (12,20), and peritonitis (10,15). The species colonizing the human oral tract are C. ochracea, C. sputigena, C. gingivalis, C. haemolytica, and C. granulosa (10).…”

Section: Case Reportmentioning

confidence: 99%

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Capnocytophaga Lung Abscess in a Patient with Metastatic Neuroendocrine Tumor

Thirumala

Rappo²,

Babady

et al. 2012

J Clin Microbiol

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Capnocytophaga species are known commensals of the oral cavity of humans and animals (mainly dogs and cats) and are a rare cause of respiratory tract infections. We report a case of cavitary lung abscess caused by a Capnocytophaga species in a patient with a metastatic neuroendocrine tumor. CASE REPORTA 39-year-old man with a metastatic, well-differentiated neuroendocrine tumor presented with fever and productive cough for 2 weeks. The patient's primary tumor was a large right infrahilar lung mass causing obstruction of the bronchus intermedius and extended to the right-middle-lobe (RML) and rightlower-lobe (RLL) bronchi. He also had multiple bilobar liver metastases. He had been treated with monthly octreotide injections for symptom control of carcinoid syndrome (hormone hypersecretion), which often occurs in metastatic neuroendocrine tumors. He had also recently been on chemotherapy with oral capecitabine and temozolomide.Two weeks after planned right hepatic artery embolization for liver metastasis and symptom control, he experienced lowgrade fevers with cough productive of foul-smelling melanoptysis, night sweats, malaise, and weight loss. The symptoms did not respond to a brief course of azithromycin. A computed tomograph (CT) of the chest revealed a new 8.7-by 6.4-cm cavitary abscess in the right lung. He was empirically treated with oral clindamycin for presumed aspiration pneumonia and anaerobic coverage but was admitted 2 days later for progressive symptoms.His medical history included three episodes of pneumonia that predated the cancer diagnosis, heavy marijuana use for 20 years (he had quit 1 month prior to his current admission), and occasional alcohol use; he denied cigarette smoking. He had four cats at home and denied recent travel, sick contacts, exposure to tuberculosis, or prior incarceration; he worked as a salesman for a waste transfer facility.On admission, he was febrile (38.4°C) and tachycardic without acute distress. Physical examination revealed an illappearing young man with normal dentition; a chest exam was remarkable for decreased breath sounds at the right base, egophony, and dullness to percussion on the right. Laboratory values showed an elevated white blood cell (WBC) count of 24,800/l (neutrophils, 87%), thrombocytosis of 878,000/l (normal, 160,000 to 400,000), mild hyponatremia (132 meq of sodium/liter; normal, 136 to 144), a low albumin level of 2.9 g/dl, and a high international normalized ratio (INR) of 1.83 (normal, 0.85 to 1.17). A chest radiograph obtained at admission and a repeat chest CT revealed an increase in the size of the right lung abscess to 10.2 by 8.3 cm (Fig. 1A and B). The patient was started on intravenous antibiotics, including piperacillintazobactam and vancomycin. A purified protein derivative (PPD) was placed and was negative; sputum samples were also negative for acid-fast bacilli (AFB) on smears, and mycobacterial culture remained negative after 42 days. Blood cultures were negative after 5 days of incubation. Serum Aspergillus galactomannan antigen,...

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Antimicrobial treatment of Capnocytophaga infections

Cited by 114 publications

References 64 publications

On the role, ecology, phylogeny, and structure of dual-family immunophilins

On the role, ecology, phylogeny, and structure of dual-family immunophilins

Case Report: Capnocytophaga canimorsus A Novel Pathogen for Joint Arthroplasty

Capnocytophaga Lung Abscess in a Patient with Metastatic Neuroendocrine Tumor

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