2012
DOI: 10.1039/c2gc16090k
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Antimicrobial toxicity studies of ionic liquids leading to a ‘hit’ MRSA selective antibacterial imidazolium salt

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Cited by 103 publications
(80 citation statements)
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References 19 publications
(33 reference statements)
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“…2 Readily biodegradable amino acid ILs. 15 Biodegradation values assessed by the CO 2 Headspace test ISO 14593. example, 1-methylimidazole), to yield the target ILs (4-15) ( Table 1). Compound 4 has been previously prepared by Gathergood et al in 98% yield using THF as the solvent, 15 however a slightly lower yield of 4 was obtained using diethyl ether (entry 1).…”
Section: Resultsmentioning
confidence: 99%
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“…2 Readily biodegradable amino acid ILs. 15 Biodegradation values assessed by the CO 2 Headspace test ISO 14593. example, 1-methylimidazole), to yield the target ILs (4-15) ( Table 1). Compound 4 has been previously prepared by Gathergood et al in 98% yield using THF as the solvent, 15 however a slightly lower yield of 4 was obtained using diethyl ether (entry 1).…”
Section: Resultsmentioning
confidence: 99%
“…During the reaction condition optimisation for alkylating reagent 26 (see Table 3 for optimisation), metric analysis was also conducted on each of the reaction conditions (entries 1-4). The original conditions reported by Coleman et al 15 for the formation of 26 involving the use of two equivalents of triethylamine and purification by column chromatography led to a poor atom economy of 50% and an E-factor of 705.1. The solvent and mass intensities of the reaction are similarly affected.…”
Section: Green Chemistry Metricsmentioning
confidence: 98%
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“…36 In fact, the minimal inhibitory concentration (MIC) values for imidazolium, pyridinium, phosphonium, and ammonium-based ILs regarding various types of bacteria and fungi show improved antimicrobial activities relative to conventional antimicrobial agents. 24,28,36,37 This antimicrobial activity has been found to be closely related to the length of the alkyl chain of the cation, with longer chains exhibiting greater antimicrobial efficacy. 12,34,37 However, this biological efficacy does not increase indefinitely with increasing chain length, and this phenomenon has been referred to as the cutoff effect.…”
Section: Introductionmentioning
confidence: 97%
“…Gathergood and co-workers have recently studied amino acid-functionalized imidazolium salts on their activity towards MRSA (methicillin-resistant Staphylococcus aureus) [11]. Some of the salts were sufficiently active and additionally showed a reasonable level of biodegradibility.…”
Section: Introductionmentioning
confidence: 99%