Antimicrobial therapy utilization in neonates with hypoxic-ischemic encephalopathy (HIE): a report from the Children’s Hospital Neonatal Database (CHND)

Rao, Rakesh; Lee, Kyong Soon; Zaniletti, Isabella; Yanowitz, Toby; DiGeronimo, Robert; Dizon, Maria L.V.; Hamrick, Shannon E. G.; Natarajan, Girija; Peeples, Eric S.; Murthy, Karna; Mathur, Amit M.; Massaro, An N.

doi:10.1038/s41372-019-0527-2

Cited by 19 publications

(25 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Increased risk for infections during therapeutic hypothermia has been described previously [6]. In the literature, the association of (maternal/placental/neonatal) infection/ inflammation in neonates with HIE and unfavourable outcome has been emphasised [6,23,24]. The short-term outcome of infection (defined as culture proven sepsis, pneumonia, necrotising enterocolitis Bell stage 2-3) varied between centres.…”

Section: Original Articlementioning

confidence: 99%

“…However, additional complications, which might require specific medical treatment, may occur because of perinatal asphyxia or secondary effects of the intensive care treatment, and such as seizures, arterial hypotension and infections [3]. These short-term outcomes are known in neonatal care to increase overall morbidity and mortality and worsen the neurodevelopmental outcome, with specific evidence in neonates with HIE [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Centre-specific differences in short-term outcomes in neonates with hypoxic-ischaemic encephalopathy

Grass¹,

Brotschi²,

Hagmann³

et al. 2021

Swiss Med Wkly

View full text Add to dashboard Cite

AIMS OF THE STUDY:To investigate and compare the centre-specific short-term outcome indicators seizures, arterial hypotension, infection and mortality during therapeutic hypothermia until discharge from the neonatal/paediatric intensive care unit in term and near-term neonates with hypoxic-ischaemic encephalopathy (HIE) registered in the Swiss National Asphyxia and Cooling Register between 2011 and 2018.METHODS: Retrospective analysis of prospectively collected national register data between 1 January 2011 and 31 December 2018. Pregnancy, maternal, delivery and neonatal characteristics were compared between the centres. Four short-term outcomes were defined: seizures, arterial hypotension, infection and mortality. The outcome indicators were defined as stated in the protocol of the Swiss National Asphyxia and Cooling Register. Descriptive analyses of the de-identified centre to centre analysis were performed, and standardised observed-to-expected values (risk adjusted for male sex, small for gestational age, Sarnat score on admission, pregnancy/delivery complications) of each centre were compared using with the entire network indirectly standardised mortality/morbidity ratio charts. RESULTS: 570 cooled neonates with HIE receiving therapeutic hypothermia in 10 different centres were included. Clinical or subclinical seizures were reported in a median of 32% (range 17-49%). Arterial hypotension occurred in a median of 62% (range 30-90%). Median infection rate was 10% (range 0-31%). Median mortality rate until discharge was 14% (range 0-25%).CONCLUSIONS: Short-term outcome indicators of seizures, arterial hypotension, infection and mortality showed significant differences in incidence between the centres. These data will help to establish benchmarks for the assessed outcome measures. Benchmarking is a con-tinuous need with the ultimate goal of improving modifiable short-term outcomes in neonates with HIE.

show abstract

Section: Original Articlementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Centre-specific differences in short-term outcomes in neonates with hypoxic-ischaemic encephalopathy

Grass¹,

Brotschi²,

Hagmann³

et al. 2021

Swiss Med Wkly

View full text Add to dashboard Cite

show abstract

“…Two additional studies were included following screening of 1,030 references and citations from already included studies. This led to inclusion of nine studies for this systematic review ( 55 – 63 ). An overview of the selection process is illustrated in the PRISMA flow diagram ( Figure 1 ).…”

Section: Resultsmentioning

confidence: 99%

“…Eight cohort studies ( 55 – 61 , 63 ) and one case-control study ( 62 ) were included. Table 1 provides number, gestational age, birth weight, and gender of the newborns, separated by infection status when possible.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Neurological Outcome Following Newborn Encephalopathy With and Without Perinatal Infection: A Systematic Review

et al. 2021

View full text Add to dashboard Cite

Background: Studies have suggested that neurological outcome may differ in newborns with encephalopathy with and without perinatal infection. We aimed to systematically review this association.Methods: We conducted this systematic review according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Studies were obtained from four databases including Pubmed, Embase, Web of Science, and The Cochrane Database. Newborns with encephalopathy with and without markers of perinatal infection were compared with regard to neurodevelopmental assessments, neurological disorders, and early biomarkers of brain damage. Risk of bias and quality of evidence were assessed by the Newcastle-Ottawa scale and Grading of Recommendations Assessment, Development and Evaluation (GRADE).Results: We screened 4,284 studies of which eight cohort studies and one case-control study met inclusion criteria. A narrative synthesis was composed due to heterogeneity between studies. Six studies were classified as having low risk of bias, while three studies were classified as having high risk of bias. Across all outcomes, the quality of evidence was very low. The neurological outcome was similar in newborns with encephalopathy with and without markers of perinatal infection.Conclusions: Further studies of higher quality are needed to clarify whether perinatal infection may affect neurological outcome following newborn encephalopathy.Systematic Review Registration:https://www.crd.york.ac.uk/prospero/, identifier CRD42020185717.

show abstract

Neonatal Encephalopathy

Mietzsch¹,

Juul²

2024

Avery's Diseases of the Newborn

View full text Add to dashboard Cite

Antimicrobial therapy utilization in neonates with hypoxic-ischemic encephalopathy (HIE): a report from the Children’s Hospital Neonatal Database (CHND)

Cited by 19 publications

References 46 publications

Centre-specific differences in short-term outcomes in neonates with hypoxic-ischaemic encephalopathy

Centre-specific differences in short-term outcomes in neonates with hypoxic-ischaemic encephalopathy

Neurological Outcome Following Newborn Encephalopathy With and Without Perinatal Infection: A Systematic Review

Neonatal Encephalopathy

Contact Info

Product

Resources

About