Antimicrobial therapy for patients with severe sepsis and septic shock: An evidence-based review

Abstract

Since the prompt institution of therapy that is active against the causative pathogen is one of the most important predictors of outcome, clinicians must establish a system for rapid administration of a rationally chosen drug or combination of drugs when sepsis or septic shock is suspected. The expanding number of antibacterial, antifungal, and antiviral agents available provides opportunities for effective empiric and specific therapy. However, to minimize the promotion of antimicrobial resistance and cost and to maximize efficacy, detailed knowledge of the likely pathogens and the properties of the available drugs is necessary for the intensivist.

What Are the Predictive Factors of Severe Conditions in Acute Obstructive Pyelonephritis?

“…Bacteremia is detected in approximately 30-50% of cases of severe sepsis and septic shock [20,21]. Kamei et al [11] reported that a positive blood culture is a risk factor for septic shock in patients with obstructive pyelonephritis (OR, 9.11), and bacteremia in severe acute pyelonephritis showed significant association with a hospital stay longer than 14 days (OR, 3.71) [12].…”

Shock séptico en pediatría II: Enfoque actual en el diagnóstico y tratamiento

“…El tratamiento antibiótico es una de las bases fundamentales del tratamiento de la sepsis 64 , su cumplimiento guarda estrecha relación con el pronóstico del paciente 4,65 . En un trabajo clásico, Kumar et al 4 , demostraron en población adulta un aumento de la mortalidad en un 7% por cada hora transcurrida sin uso de antibiótico.…”

Epidemiología de la sepsis en unidades de cuidado intensivo en Colombia

“…These conditions are generally associated with multiple organ failure as final outcome (1)(2)(3)(4)(5). Over the past 30 years, the worldwide incidence of sepsis has increased by 13.7% per year (1)(2)(3)(4)(5).…”

“…These conditions are generally associated with multiple organ failure as final outcome (1)(2)(3)(4)(5). Over the past 30 years, the worldwide incidence of sepsis has increased by 13.7% per year (1)(2)(3)(4)(5). It is therefore estimated that more than 18 million people suffer from sepsis each year and more than five million of them die (1)(2)(3)(4)(5).…”

“…Over the past 30 years, the worldwide incidence of sepsis has increased by 13.7% per year (1)(2)(3)(4)(5). It is therefore estimated that more than 18 million people suffer from sepsis each year and more than five million of them die (1)(2)(3)(4)(5). This increase is arguably due to increasing numbers of people aged over 65 years (60% of septic patients are more than 65 years old), to more frequent diseases and therapies causing immunosuppression, and to widespread use of diagnostic and/or therapeutic invasive procedures.…”