Antimicrobial susceptibility testing of Finnish Bordetella pertussis isolates collected during 2006–2017

Lönnqvist, Emilia; Barkoff, Alex‐Mikael; Mertsola, Jussi; He, Qiushui

doi:10.1016/j.jgar.2018.02.012

Cited by 15 publications

(11 citation statements)

References 17 publications

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“…There are few reports of erythromycin-resistant B. pertussis [3,5,45,46]. Resistance is low or none in European countries [47], Australia [48] and the US [49] where the use of antibiotics is controlled and guided by microbiological diagnosis. It will be interesting to see how the B. pertussis population evolves in countries where there is a similar high usage of antibiotics to China.…”

Section: Discussionmentioning

confidence: 99%

Genomic epidemiology of erythromycin-resistant Bordetella pertussis in China

Wang

Luan

et al. 2019

Emerging Microbes & Infections

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Macrolides such as erythromycin are the empirical treatment of Bordetella pertussis infections. China has experienced an increase in erythromycin-resistant B. pertussis isolates since they were first reported in 2013. Here, we undertook a genomic study on Chinese B. pertussis isolates from 2012 to 2015 to elucidate the origins and phylogenetic relationships of erythromycin-resistant B. pertussis isolates in China. A total of 167 Chinese B. pertussis isolates were used for antibiotic sensitivity testing and multiple locus variable-number tandem repeat (VNTR) analysis (MLVA). All except four isolates were erythromycin-resistant and of the four erythromycin-sensitive isolates, three were non-ptxP1 . MLVA types (MT), MT55, MT104 and MT195 were the predominant types. Fifty of those isolates were used for whole genome sequencing and phylogenetic analysis. Genome sequencing and phylogenetic analysis revealed three independent erythromycin-resistant lineages and all resistant isolates carried a mutation in the 23S rRNA gene. A novel fhaB3 allele was found uniquely in Chinese ptxP1 isolates and these Chinese ptxP1-ptxA1-fhaB3 had a 5-fold higher mutation rate than the global ptxP1-ptxA1 B. pertussis population. Our results suggest that the evolution of Chinese B. pertussis is likely to be driven by selection pressure from both vaccination and antibiotics. The emergence of the new non-vaccine fhaB3 allele in Chinese B. pertussis population may be a result of selection from vaccination, whereas the expansion of ptxP1-fhaB3 lineages was most likely to be the result of selection pressure from antibiotics. Further monitoring of B. pertussis in China is required to better understand the evolution of the pathogen.

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Section: Discussionmentioning

confidence: 99%

Genomic epidemiology of erythromycin-resistant Bordetella pertussis in China

Wang

Luan

et al. 2019

Emerging Microbes & Infections

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“…1 and appendix) [6][7][8][9] . The incidence of MRBP in other countries, except China, also appears to be very low according to previous studies [10][11][12][13] . In China, erythromycin has been used for treatment of pertussis since the 1980s, with few MRBP being isolated prior to 2008 [14] .…”

Section: Emergence Of Macrolide-resistant B Pertussis In Chinamentioning

confidence: 67%

Emerging macrolide resistance in Bordetella pertussis in mainland China: Findings and warning from the global pertussis initiative

Feng

Chiu

Heininger

et al. 2021

The Lancet Regional Health - Western Pacific

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Whooping cough, or pertussis, is a highly communicable infectious disease caused by the bacterium Bordetella pertussis. Vaccination once reduced the incidence of the disease, but a global resurgence of the infection happened during the past two decades, likely due to the waning immunity of vaccination. Macrolides such as erythromycin and azithromycin are the drugs of primary choice for treatment. In this personal view, we call for attention to macrolide-resistant B. pertussis (MRBP), which has emerged and prevailed in mainland China for years and are exclusively mediated by mutations in the 23S rRNA gene. Whether the prevalence of MRBP in China results from overuse of azithromycin in clinical medicine remains unknown. The incidence of MRBP is low in other countries, but this could be a technical illusion since China employs culture as the mainstream diagnostic method whereas nucleic-acid amplification test being widely used in other countries fail to test antimicrobial susceptibility. Given the increasingly frequent global travel that facilitates microbial transmission worldwide, there is a pressing need to perform international surveillance on MRBP to prevent the potential circulation of the organism. Finding alternative agents that possess good activity against B. pertussis is also urgently required.

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“…It is recommended to use azithromycin 500 mg once a day for five days as a first-line therapy. One double strength tablet of trimethoprim-sulfamethoxazole for 14 days is an acceptable alternative for people with macrolide allergies [7]. Cough suppression is important to avoid mechanical complications.…”

Section: Discussionmentioning

confidence: 99%

Coughing Up a Lung: A Curious Case of Pertussis

Madi

Shahwan

Nayar

et al. 2019

Cureus

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Pertussis is a commonly underdiagnosed infection with incidence that has been steadily rising in adolescents and adults over the last three decades. Some reports suggested cyclical pattern of pertussis infection occurrence with peaks every two to five years. The complications of pertussis can be infectious or mechanical in the setting of persistent cough. We report an unusual case of a 67-year-old woman who presented with combined lung and liver extrusion in the setting of pertussis infection. This article will review the systematic approach of diagnosis and management of pertussis infections in adults.

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Antimicrobial susceptibility testing of Finnish Bordetella pertussis isolates collected during 2006–2017

Cited by 15 publications

References 17 publications

Genomic epidemiology of erythromycin-resistant Bordetella pertussis in China

Genomic epidemiology of erythromycin-resistant Bordetella pertussis in China

Emerging macrolide resistance in Bordetella pertussis in mainland China: Findings and warning from the global pertussis initiative

Coughing Up a Lung: A Curious Case of Pertussis

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