Antimicrobial susceptibility profiles of anaerobic bacteria, isolated from human clinical specimens, within different European and surrounding countries. A joint ESGAI study

Surveillance of Antimicrobial Susceptibility of Anaerobe Clinical Isolates in Southeast Austria: Bacteroides fragilis Group Is on the Fast Track to Resistance

“…Most infections, where anaerobic bacteria are involved, were treated empirically, mainly with betalactam antibiotics [ 5 ]. Due to worldwide increase in resistance rates, especially for Bacteroides spp., and extensive differences in the antimicrobial susceptibility patterns of anaerobic bacteria isolated within different countries, local surveillance studies on a regular basis are highly recommended [ 9 , 12 ].…”

“…Other techniques like the MIC gradient testing method (e.g., ETEST ® ) are costly and not always affordable for smaller laboratories or laboratories of middle- and low-income countries. As studies on the antimicrobial susceptibility profile of anaerobic bacteria are underrepresented in the literature [ 9 ], we present antimicrobial susceptibility testing (AST) results of 114 Gram positive anaerobic isolates and 110 BFGI determined by MIC gradient testing derived from clinical specimens in Southeast Austria. Furthermore, we performed disk diffusion testing of BFGI, using the zone diameter breakpoints published by Nagy et al in 2015 [ 10 ], and compared the results of the two methods to each other.…”

How to: prophylactic interventions for prevention of Clostridioides difficile infection

“…However, this difference did not result in a statistically significant reduction in CDI rates. Also important is the finding of metronidazole resistance in C. difficile and increasing reports of resistance in other anaerobes (54,55).…”

Antimicrobial Susceptibility and Clonality of Vaginally Derived Multidrug-Resistant Mobiluncus Isolates in China

“…significantly increased the proinflammatory cytokine production of vaginal epithelial cells, including the production of interleukin-1␣ (IL-1␣), IL-1␤, tumor necrosis factor-␣ (TNF-␣), and IL-8 (15), and may promote the occurrence of bacterial vaginosis and accelerate its progression. The emergence of multidrug-resistant anaerobic bacterial strains that cause vaginosis, particularly those that are resistant to metronidazole and clindamycin, represents an increasing threat to public health (16)(17)(18). Oral or vaginal administration of metronidazole or clindamycin produced an initial response in 80% to 90% of patients, but 15% to 30% of these patients relapsed within 3 months due to the possible selection of potential antimicrobial-resistant strains (19).…”