Antimicrobial Susceptibility Patterns Among Extended-Spectrum  -Lactamase-Producing Enterobacteriaceae in a Large Pediatric Hospital in the United Kingdom

Drew, Richard J.; Ormandy, Emma; Ball, Kate; Lambert, Sarah E; Paulus, Stéphane; Williams, Nicola; Cunliffe, Nigel A.

doi:10.1093/jpids/piu094

Cited by 2 publications

(2 citation statements)

References 10 publications

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“…The susceptibility pattern of isolated ESBL-E in our cohort was similar to that found in hospitals from Northwest England and North Wales between 2007 and 2012 [ 42 ]. In the Study for Monitoring Antimicrobial Resistance Trends (SMART) in Canada and the United States, susceptibility to amikacin remained high, between 95.4% and 100% [ 43 ].…”

Section: Discussionsupporting

confidence: 79%

Febrile urinary-tract infection due to extended-spectrum beta-lactamase–producing Enterobacteriaceae in children: A French prospective multicenter study

Madhi¹,

Jung²,

Timsit³

et al. 2018

PLoS ONE

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ObjectivesTo assess the management of febrile urinary-tract infection (FUTIs) due to extended-spectrum β-lactamase–producing Enterobacteriaceae (ESBL-E) in children, the Pediatric Infectious Diseases Group of the French Pediatric Society set up an active surveillance network in pediatric centers across France in 2014.Materials and methodsWe prospectively analysed data from 2014 to 2016 for all children < 18 years old who received antibiotic treatment for FUTI due to ESBL-E in 24 pediatric centers. Baseline demographic, clinical features, microbiological data and antimicrobials prescribed were collected.Results301 children were enrolled in this study. The median age was 1 year (IQR 0.02–17.9) and 44.5% were male. These infections occurred in children with history of UTIs (27.3%) and urinary malformations (32.6%). Recent antibiotic use was the main associated factor for FUTIs due to ESBL-E, followed by a previous hospitalization and travel history. Before drug susceptibility testing (DST), third-generation cephalosporins (3GC) PO/IV were the most-prescribed antibiotics (75.5%). Only 13% and 24% of children received amikacine alone for empirical or definitive therapy, respectively, whereas 88.7% of children had isolates susceptible to amikacin. In all, 23.2% of children received carbapenems in empirical and/or definitive therapy. Cotrimoxazole (24.5%), ciprofloxacin (15.6%) and non-orthodox clavulanate–cefixime combination (31.3%) were the most frequently prescribed oral options after obtaining the DST. The time to apyrexia and length of hospital stay did not differ with or without effective empirical therapy.ConclusionsWe believe that amikacin should increasingly take on a key role in the choice of definitive therapy of FUTI due to ESBL-E in children by avoiding the use of carbapenems.

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Section: Discussionsupporting

confidence: 79%

Febrile urinary-tract infection due to extended-spectrum beta-lactamase–producing Enterobacteriaceae in children: A French prospective multicenter study

Madhi¹,

Jung²,

Timsit³

et al. 2018

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…In our cohort, the susceptibility pattern of isolated ESBL was similar to that found in hospitals from Northwest England and North Wales between 2007 and 2012 [9]. In the Study for Monitoring Antimicrobial Resistance Trends (SMART) in Canada and the United States, susceptibility to amikacin remained high, between 95.4% and 100% [10].…”

Section: Discussionsupporting

confidence: 77%

Extended-Spectrum Beta-Lactamase – Producing Enterobacteriaceae Causing Urinary Tract Infections in Children in Qatar

Helal¹

2023

IJCMCR

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Objectives: Urinary tract infections (UTI) in children are most frequently due to Enterobacteriaceae. Multidrug-resistant Escherichia coli including extended-spectrum beta-lactamase (ESBL) producing organisms are becoming more prevalent. The aim of this study was to describe a cohort of children with ESBL producing organism urinary tract infections and the organism susceptibility patterns.Methods: This retrospective study evaluated a cohort of children with ESBL-induced UTI, admitted to our Pediatric Emergency Centre during a 2.5-years period. Results:In a total of 633 patients with urinary tract infection, 115 (18.2%) grew Gram-negative urinary isolates with an ESBL strain. Among of them (80%) female, (25.2%) had urinary tract abnormalities and (4.3%) had neuromuscular disorders. The most common bacteria were E coli (77.4%) then Klebsiella pneumonia (14.8%). All of the ESBL organisms were sensitive to carbapenems, with 98.7% sensitive to Amikacin, and 83% sensitive to Gentamicin. Gentamicin was used in (56.5%), Amikacin (23.5%) and Ertapenem/Meropenem (20.0%) of cases. The duration of treatment was 5-7 days but two cases relapsed. Conclusion:The proportion of urinary tract infection induced by ESBL organisms was almost 1 in 5 of patients. Carbapenems and aminoglycoside remained the corner stone in treatment of the urinary tract infection by ESBL produced organisms with very high efficacy, most cases responded to treatment within 5-7 days of intravenous single antibiotic.

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Antimicrobial Susceptibility Patterns Among Extended-Spectrum -Lactamase-Producing Enterobacteriaceae in a Large Pediatric Hospital in the United Kingdom

Cited by 2 publications

References 10 publications

Febrile urinary-tract infection due to extended-spectrum beta-lactamase–producing Enterobacteriaceae in children: A French prospective multicenter study

Febrile urinary-tract infection due to extended-spectrum beta-lactamase–producing Enterobacteriaceae in children: A French prospective multicenter study

Extended-Spectrum Beta-Lactamase – Producing Enterobacteriaceae Causing Urinary Tract Infections in Children in Qatar

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