Antimicrobial susceptibility of pathogens isolated from more than 10 000 patients with infectious respiratory diseases: a 25-year longitudinal study

Goto, Hajime; Shimada, Kaoru; Ikemoto, Hideo; Oguri, Toyoko

doi:10.1007/s10156-009-0719-3

Cited by 39 publications

(24 citation statements)

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“…But we demonstrated that clarithromycin was less antimicrobial effective in respiratory tract disease than in no respiratory tract disease significantly. Macrolide including clarithromycin is popular for treatment of respiratory infection disease in Japan [9]. Furthermore, low-dose macrolide therapy is also popular for treatment of chronic rhinosinusitis and chronic respiratory failure disease [10] [11].…”

Section: Discussionmentioning

confidence: 99%

Clinical Characteristics of Respiratory Tract-Associated Streptococcus pyogenes at General Japanese Hospital in 2014

Minami¹,

Sakakibara²,

Imura³

et al. 2015

JBM

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Streptococcus pyogenesis most popularpathogen caused respiratory tract infection disease. This study was conducted to find out the recent clinical characteristics of Streptococcus pyogenes isolates from respiratory tract at Japanese hospital in 2014. Streptococcus pyogenes was identified by standard laboratory procedure. Antimicrobial susceptibility testing was performed by micro dilution assay according to CLSI recommendation. Respiratory tract isolates were defined as isolation from pharynx, nasal discharge, tonsillar, and sputum. Total one hundred sixty-one Streptococcus pyogenes were isolated among which 136 were from respiratory tract and 25 were from non-respiratory tract. Respiratory tract-associated Streptococcus pyogenes was isolated among which 102 were from male and 59 were from female. The age incidence among 0 -1 years age group was 8, among 1 -18 years age group, 131 (p < 0.01), among 19 -64 years age group, 17 (p < 0.01), and in 65-years it was 5. Although we investigated the relationship between season and bacterial isolation, we did not find any significant differences between respiratory tract and no respiratory tract isolation. However, our study revealed that clarithromycin was less antimicrobial effective in respiratory tract disease than in no respiratory tract disease significantly (p < 0.01). Although several antibiotics such as penicillin are still effective against Streptococcus pyogenes, incidence of Streptococcus pyogenes infection is not decreasing worldwide. Our study suggests the need for continuous epidemiological surveillance of Streptococcus pyogenes.

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Section: Discussionmentioning

confidence: 99%

Clinical Characteristics of Respiratory Tract-Associated Streptococcus pyogenes at General Japanese Hospital in 2014

Minami¹,

Sakakibara²,

Imura³

et al. 2015

JBM

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“…The proportions of ␤-lactam-resistant isolates in general, and specifically BLNARs, are high in Japan and its neighboring countries, as described in several reports (10,11,28). In Europe, reports are less consistent, with some reports suggesting increasing proportions of isolates with ampicillin resistance (14,32), albeit at a lower level than in Japan.…”

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confidence: 95%

Increase of β-Lactam-Resistant Invasive Haemophilus influenzae in Sweden, 1997 to 2010

Resman

Ristovski

Forsgren

et al. 2012

Antimicrob Agents Chemother

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ABSTRACTThe proportions ofHaemophilus influenzaeresistant to ampicillin and other β-lactam antibiotics have been low in Sweden compared to other countries in the Western world. However, a near-doubled proportion of nasopharyngeal SwedishH. influenzaeisolates with resistance to β-lactams has been observed in the last decade. In the present study, the epidemiology and mechanisms of antimicrobial resistance ofH. influenzaeisolates from blood and cerebrospinal fluid in southern Sweden from 1997 to 2010 (n= 465) were studied. Antimicrobial susceptibility testing was performed using disk diffusion, and isolates with resistance to any tested β-lactam were further analyzed in detail. We identified a significantly increased (P= 0.03) proportion of β-lactam-resistant invasiveH. influenzaeduring the study period, which was mainly attributed to a significant recent increase of β-lactamase-negative β-lactam-resistant isolates (P= 0.04). Furthermore, invasive β-lactamase-negative β-lactam-resistantH. influenzaeisolates from 2007 and onwards were found in higher proportions than the corresponding proportions of nasopharyngeal isolates in a national survey. Multiple-locus sequence typing (MLST) of this group of isolates did not completely separate isolates with different resistance phenotypes. However, one cluster of β-lactamase-negative ampicillin-resistant (BLNAR) isolates was identified, and it included isolates from all geographical areas. A truncated variant of a β-lactamase gene with a promoter deletion,blaTEM-1-PΔ dominated among the β-lactamase-positiveH. influenzaeisolates. Our results show that the proportions of β-lactam-resistant invasiveH. influenzaehave increased in Sweden in the last decade.

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“…Infections caused by P. aeruginosa are often difficult to treat and are a great challenge to physicians and patients, raising morbidity and mortality rates (5,6). Previous studies have revealed that the number of drug-resistant P. aeruginosa strains is increasing and the rate of resistance to carbapenems goes up every year (7)(8)(9). For instance, The CAPITAL surveillance program tested the susceptibility of 2,722 P. aeruginosa isolates, which revealed that the rates of resistance to imipenem, meropenem, and ceftazidime were 21.9, 15.4, and 15.2%, respectively (10).…”

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confidence: 99%

Multilocus Sequence Typing Reveals Genetic Diversity of Carbapenem- or Ceftazidime-Nonsusceptible Pseudomonas aeruginosa in China

Wang

Zhou

et al. 2013

Antimicrob Agents Chemother

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It is unclear whether the genetic background of drug-resistant Pseudomonas aeruginosa was disseminated from a certain clone. Thus, we performed MLST (multilocus sequence typing) of 896 P. aeruginosa isolates that were nonsusceptible to imipenem, meropenem, or ceftazidime. This revealed 254 sequence types (STs), including 104 new STs and 34 STs with novel alleles. Thirtythree clonal complexes and 404 singletons were found. In conclusion, drug-resistant P. aeruginosa clones can be developed from diverse genetic backgrounds. Pseudomonas aeruginosa is one of the most common opportunistic pathogens and can cause severe diseases in humans, especially patients in intensive care units, burn centers, and cystic fibrosis centers (1-4). Infections caused by P. aeruginosa are often difficult to treat and are a great challenge to physicians and patients, raising morbidity and mortality rates (5, 6). Previous studies have revealed that the number of drug-resistant P. aeruginosa strains is increasing and the rate of resistance to carbapenems goes up every year (7-9). For instance, The CAPITAL surveillance program tested the susceptibility of 2,722 P. aeruginosa isolates, which revealed that the rates of resistance to imipenem, meropenem, and ceftazidime were 21.9, 15.4, and 15.2%, respectively (10). MLST (multilocus sequence typing) is an unambiguous molecular typing method that is used mostly to assess local outbreaks of infections (11-13). Study of population genetic backgrounds is also an application for MLST. For example, previous studies have indicated that the P. aeruginosa population structure is nonclonal (14-17). Specifically, Kidd et al. collected 501 P. aeruginosa isolates from an extensive region and various sources and identified 274 different sequence types (STs) that were confirmed as nonclonal (18). Some studies have focused on different geographic areas, but the samples used were of limited size or from the environment (16,18). A large-scale epidemiological study of drug-resistant P. aeruginosa based on MLST has not been conducted in China. This study was conducted in order to investigate the drug resistance of P. aeruginosa in China and its genetic background based on MLST.A total of 2,818 P. aeruginosa isolates were collected in 2010 from 65 hospitals in 22 regions of China. Susceptibilities to 16 antimicrobial agents were evaluated by the disk diffusion method. The results were interpreted according to the 2012 Clinical and Laboratory Standards Institute (CLSI) guidelines (19), and P. aeruginosa ATCC 27853 was used as the control. The results showed that carbapenems (imipenem and meropenem), cephalosporins (cefepime and ceftazidime), penicillins (piperacillin and tazobactam-piperacillin), quinolones (ciprofloxacin), and aminoglycosides (amikacin and gentamicin) were more active than other drugs, with susceptibility rates ranging from 71.2 to 85.2%. The rates of isolate resistance to imipenem, meropenem, and ceftazidime were 23.1, 18.1, and 15.3%, respectively. Cefoperazone, sulbactam-cefoperazone, and aztre...

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Antimicrobial susceptibility of pathogens isolated from more than 10 000 patients with infectious respiratory diseases: a 25-year longitudinal study

Cited by 39 publications

References 0 publications

Clinical Characteristics of Respiratory Tract-Associated Streptococcus pyogenes at General Japanese Hospital in 2014

Clinical Characteristics of Respiratory Tract-Associated Streptococcus pyogenes at General Japanese Hospital in 2014

Increase of β-Lactam-Resistant Invasive Haemophilus influenzae in Sweden, 1997 to 2010

Multilocus Sequence Typing Reveals Genetic Diversity of Carbapenem- or Ceftazidime-Nonsusceptible Pseudomonas aeruginosa in China

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