Antimicrobial Susceptibility of Mannheimia haemolytica Isolates from Cattle in Japan from 2001 to 2002

Esaki, Hidetake; Asai, Tetsuo; Kojima, Akira; Ishihara, Katsuya; Morioka, Ayako; Tsutsumi, Yutaka; Takahashi, Toshio

doi:10.1292/jvms.67.75

Cited by 24 publications

(16 citation statements)

References 11 publications

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“…Seventy-two percent of M. haemolytica isolated in this study were antimicrobial resistant, about twice the percentage detected for M. haemolytica isolated from the nasopharynx of cattle displaying BRD (35%) in a previous study from our group (19). Furthermore, evidence for multidrug resistance against more than three antimicrobials was found in 45% of the isolates collected during this project, results agreeing with reports that multidrug resistance in BRD pathogens is on the increase (35)(36)(37).…”

Section: Discussionsupporting

confidence: 91%

Pathogens of Bovine Respiratory Disease in North American Feedlots Conferring Multidrug Resistance via Integrative Conjugative Elements

et al. 2014

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In this study, we determined the prevalence of bovine respiratory disease (BRD)-associated viral and bacterial pathogens in cattle and characterized the genetic profiles, antimicrobial susceptibilities, and nature of antimicrobial resistance determinants in collected bacteria. Nasopharyngeal swab and lung tissue samples from 68 BRD mortalities in Alberta, Canada (n ‫؍‬ 42), Texas (n ‫؍‬ 6), and Nebraska (n ‫؍‬ 20) were screened using PCR for bovine viral diarrhea virus (BVDV), bovine respiratory syncytial virus, bovine herpesvirus 1, parainfluenza type 3 virus, Mycoplasma bovis, Mannheimia haemolytica, Pasteurella multocida, and Histophilus somni. Excepting bovine herpesvirus 1, all agents were detected. M. haemolytica (91%) and BVDV (69%) were the most prevalent, with cooccurrence in 63% of the cattle. Isolates of M. haemolytica (n ‫؍‬ 55), P. multocida (n ‫؍‬ 8), and H. somni (n ‫؍‬ 10) from lungs were also collected. Among M. haemolytica isolates, a clonal subpopulation (n ‫؍‬ 8) was obtained from a Nebraskan feedlot. All three bacterial pathogens exhibited a high rate of antimicrobial resistance, with 45% exhibiting resistance to three or more antimicrobials. M. haemolytica (n ‫؍‬ 18), P. multocida (n ‫؍‬ 3), and H. somni (n ‫؍‬ 3) from Texas and Nebraska possessed integrative conjugative elements (ICE) that conferred resistance for up to seven different antimicrobial classes. ICE were shown to be transferred via conjugation from P. multocida to Escherichia coli and from M. haemolytica and H. somni to P. multocida. ICE-mediated multidrug-resistant profiles of bacterial BRD pathogens could be a major detriment to many of the therapeutic antimicrobial strategies currently used to control BRD.

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Section: Discussionsupporting

confidence: 91%

Pathogens of Bovine Respiratory Disease in North American Feedlots Conferring Multidrug Resistance via Integrative Conjugative Elements

et al. 2014

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“…In Japan, enrofloxacin (ERFX) was first approved for bovine pneumonia in 1991, and three fluoroquinolone compounds have been approved for bovine pneumonia to date. Our previous study showed that all 27 isolates of M. haemolytica were susceptible to fluoroquinolones during the period of 2001 to 2002 [1]. However, we observed emergence of fluoroquinolone-resistant M. haemolytica in 2004 in our surveys (unpublished data).…”

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confidence: 42%

Mutations in GyrA and ParC in Fluoroquinolone-Resistant Mannheimia haemolytica Isolates from Cattle in Japan

Ozawa

Asai

Sameshima

2009

The Journal of Veterinary Medical Science

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ABSTRACT. Nine isolates of Mannheimia haemolytica, comprising an enrofloxacin (ERFX)-resistant isolate, five nalidixic acid-resistant isolates and three susceptible isolates, from diseased cattle were subjected to sequence analysis of the quinolone resistance-determining regions (QRDRs) of the gyrA and parC genes. An ERFX-resistant isolate was shown to have two amino acid substitutions in GyrA (S83F and D87G) and one substitution in ParC (S80I). Three mutations in the QRDRs of GyrA were found in the NA-resistant isolates: S83Y in two isolates, S83F in two isolates and D87G in one isolate.

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“…The breakpoints of ABPC, CEZ, CP, GM, KM, NA and TMP were adopted to the same breakpoints by NCCLS guidelines [15]. The breakpoints of CL, DSM, OTC and ERFX have been described in our previous report [9]. Bacteriophage typing was performed according to the methods of the Public Health Laboratory Service (PHLS), London, United Kingdom [1].…”

mentioning

confidence: 99%

Changes of Multi-Drug Resistance Pattern in Salmonella enterica Subspecies enterica Serovar Typhimurium Isolates from Food-Producing Animals in Japan

Kawagoe

Mine

Asai

et al. 2007

The Journal of Veterinary Medical Science

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ABSTRACT. A total of 153 isolates of Salmonella Typhimurium derived from food-producing animals in Japan between 2002 and 2005 were investigated for antimicrobial resistance and phage types related to definitive phage type 104 (DT104). The predominant resistance type was resistance to ampicillin, dihydrostreptomycin, kanamycin, and oxytetracycline in bovine (45.2%, 48/104) and resistance to dihydrostreptomycin and oxytetracycline in porcine isolates (58.7%, 27/48). DT104-related phage type was found in 32 of 104 bovine isolates, two of 48 porcine isolates, and one of eight isolates from poultry, showing that the proportion of the phage type in S. Typhimurium isolates from cattle and pigs significantly (P<0.01) decreased from 71. 9% and 31.4% in 1999-2001 to 30.8% and 4.1% in 2002-2005, respectively. KEY WORDS: antimicrobial resistance, food-producing animal, Salmonella Typhimurium.

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Antimicrobial Susceptibility of Mannheimia haemolytica Isolates from Cattle in Japan from 2001 to 2002

Cited by 24 publications

References 11 publications

Pathogens of Bovine Respiratory Disease in North American Feedlots Conferring Multidrug Resistance via Integrative Conjugative Elements

Pathogens of Bovine Respiratory Disease in North American Feedlots Conferring Multidrug Resistance via Integrative Conjugative Elements

Mutations in GyrA and ParC in Fluoroquinolone-Resistant Mannheimia haemolytica Isolates from Cattle in Japan

Changes of Multi-Drug Resistance Pattern in Salmonella enterica Subspecies enterica Serovar Typhimurium Isolates from Food-Producing Animals in Japan

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