Antimicrobial susceptibility of Helicobacter pylori to six antibiotics currently used in Spain

Cuadrado‐Lavín, Antonio; Salcines-Caviedes, José R.; Carrascosa, Miguel F; Mellado, Purificación; Monteagudo, Idoia; Llorca, Javier; Cobo, M.; Campos, M. Rosario; Ayestarán, Blanca; Fernández-Pousa, Antonio; González-Colominas, Elena

doi:10.1093/jac/dkr410

Cited by 65 publications

(54 citation statements)

References 21 publications

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“…Wueppenhorstet al (20) and Larsen et al (21) in Norway reported H. pylori amoxicillin and tetracycline resistance rates of 1.4% and 0% in Germany and 10% and 0% in Norway, respectively. Cuadrado-Lavínet al (27) in Spain and Georgopoulos et al (17) in Greece reported no amoxicillin resistance. Boyanova et al (18) reported 2% tetracycline resistance.…”

Section: Ethical Considerationsmentioning

confidence: 93%

“…The metronidazole resistance of H. pylori is closely related to geographic location and to the use of this drug for its antiparasitic activity. In African countries, the prevalence of metronidazole resistance is approximately 90%; however, this rate decreases to 45% in Spain and 22.5% in Norway (19) (21) (25) (26) (27) .…”

Section: Ethical Considerationsmentioning

confidence: 99%

“…Although the eradication success of the new regimen containing levofl oxacin is as high as 90%, emerging studies are reporting increasing quinolone resistance rates (27) (37) (38) . In Europe, levofl oxacin resistance rates have reached 18% (19) (21) .…”

Section: Ethical Considerationsmentioning

confidence: 99%

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Antimicrobial resistance of Helicobacter pylori strains to five antibiotics, including levofloxacin, in Northwestern Turkey

Caliskan

Tokman

Erzın

et al. 2015

Rev. Soc. Bras. Med. Trop.

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Introduction: Antibiotic resistance is the main factor that affects the effi cacy of current therapeutic regimens against Helicobacter pylori. This study aimed to determine the rates of resistance to effi cacy clarithromycin, amoxicillin, tetracycline, levofl oxacin and metronidazole among H. pylori strains isolated from Turkish patients with dyspepsia. Methods: H. pylori was cultured from corpus and antrum biopsies that were collected from patients with dyspeptic symptoms, and the antimicrobial susceptibility of H. pylori was determined using the E-test (clarithromycin, amoxicillin, tetracycline, metronidazole and levofl oxacin) according to the EUCAST breakpoints. Point mutations in the 23S rRNA gene of clarithromycin-resistant strains were investigated using realtime PCR. Results: A total of 98 H. pylori strains were isolated, all of which were susceptible to amoxicillin and tetracycline. Of these strains, 36.7% (36/98) were resistant to clarithromycin, 35.5% (34/98) were resistant to metronidazole, and 29.5% (29/98) were resistant to levofl oxacin. Multiple resistance was detected in 19.3% of the isolates. The A2143G and A2144G point mutations in the 23S rRNA-encoding gene were found in all 36 (100%) of the clarithromycin-resistant strains. Additionally, the levofl oxacin MIC values increased to 32 mg/L in our H. pylori strains. Finally, among the clarithromycin-resistant strains, 27.2% were resistant to levofl oxacin, and 45.4% were resistant to metronidazole. Conclusions: We conclude that treatment failure after clarithromycin-or levofl oxacinbased triple therapy is not surprising and that metronidazole is not a reliable agent for the eradication of H. pylori infection in Turkey.

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Section: Ethical Considerationsmentioning

confidence: 93%

Section: Ethical Considerationsmentioning

confidence: 99%

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Antimicrobial resistance of Helicobacter pylori strains to five antibiotics, including levofloxacin, in Northwestern Turkey

Caliskan

Tokman

Erzın

et al. 2015

Rev. Soc. Bras. Med. Trop.

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“…The standard CAM-based triple regimen for 7-14 days is still the first option for eradicating H. pylori in Bangladesh, and LVX-based is the second line treatment [13]. Because antibiotic resistance is increasing worldwide [14,15], it is critical to examine current drug resistance rates in Bangladesh. In this study, we aimed to determine the antibiotic susceptibility of H. pylori to CAM, MNZ, AMX, TCN and LVX in Bangladesh.…”

Section: Introductionmentioning

confidence: 99%

Helicobacter pylori antibiotic susceptibility patterns in Bangladesh: Emerging levofloxacin resistance

Aftab

Miftahussurur

Subsomwong

et al. 2016

J Infect Dev Ctries

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Introduction: The most recent study to report Helicobacter pylori antibiotic resistance rates in Bangladesh was published 15 years ago and did not include levofloxacin. We therefore aimed to determine the current antibiotic susceptibility of H. pylori to amoxicillin, clarithromycin, metronidazole, tetracycline and levofloxacin in Bangladesh. Methodology: This study included 133 consecutive patients who underwent endoscopy examination at Dhaka Medical College in November 2014. The serial two-fold agar dilution method was used to determine the minimum inhibitory concentrations of the five antibiotics. Results: Among 56 cultured strains, H. pylori showed high rates of resistance to clarithromycin and metronidazole (39.3% and 94.6%, respectively). Moreover, levofloxacin showed an emerging antimicrobial resistance pattern (66.1%), which was higher in patients with gastritis than that in those with peptic ulcers (p = 0.02). The resistance rate of levofloxacin was significantly higher in patients living in Dhaka city compared to those living in the village (p = 0.049). However, amoxicillin and tetracycline resistance rates were very low. Resistance to both metronidazole and levofloxacin was most commonly observed. Conclusions: The rates of resistance to clarithromycin, metronidazole, and levofloxacin were high in Bangladesh, which suggests that triple therapy based on these drugs may not be useful as first-line therapies in Bangladesh. Alternative strategies such as furazolidone-based triple therapy, bismuth-based quadruple therapies, or sequential therapy may be more effective for patients in in Bangladesh.

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“…In one recent small study from Spain, the reported levofloxacin resistance rate was 14.5%. 5 It is our opinion that bacterial resistance to levofloxacin is the absolute key to treatment success in rescue therapies utilising this antibiotic. We reiterate the low/zero prevalence of resistance of levofloxacin in our local population from our previous survey.…”

mentioning

confidence: 99%

Letter: third‐line rescue therapy with levofloxacin after failure of two treatments to eradicate Helicobacter pylori infection – author's reply

Goh

2012

Aliment Pharmacol Ther

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Antimicrobial susceptibility of Helicobacter pylori to six antibiotics currently used in Spain

Cited by 65 publications

References 21 publications

Antimicrobial resistance of Helicobacter pylori strains to five antibiotics, including levofloxacin, in Northwestern Turkey

Antimicrobial resistance of Helicobacter pylori strains to five antibiotics, including levofloxacin, in Northwestern Turkey

Helicobacter pylori antibiotic susceptibility patterns in Bangladesh: Emerging levofloxacin resistance

Letter: third‐line rescue therapy with levofloxacin after failure of two treatments to eradicate Helicobacter pylori infection – author's reply

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