Antimicrobial Susceptibility of Caprine and Ovine <i>Mycoplasma ovipneumoniae</i> Isolates

Maksimović, Zinka; Bačić, Azra; Rifatbegović, Maid

doi:10.1089/mdr.2019.0465

Cited by 8 publications

(6 citation statements)

References 16 publications

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“…Our results are in overall agreement with the recent results of Maksimović et al, i.e. strains with mostly low MIC values whatever the drug considered, although significant higher MIC values were obtained from goat strains with oxytetracycline, tylosin and enrofloxacin compared to sheep (Maksimović et al, 2020a). Some MIC discrepancies in the only common strain analysed in the two studies, namely Y98, were observed for aminosides, phenicols and macrolides.…”

Section: Antimicrobial Resistancesupporting

confidence: 92%

“…Surprisingly, the host influence on MIC distribution remained limited, being statistically significant only for spectinomycin, oxytetracycline, tilmicosin and florfenicol but within a range of one dilution only. The host species difference evidenced by Maksimović et al appeared more marked for enrofloxacin (MIC90 difference of three dilutions), oxytetracycline (seven dilutions) and tylosin (six dilutions), suggesting different patterns of use between the two countries (Maksimović et al, 2020a). In France, the situation of M. ovipneumoniae contrasts with that previously observed for the M. agalactiae species, one of the agents causing contagious agalactia syndrome in small ruminants (Poumarat et al, 2016), for which the animal host influence was marked for several drugs.…”

Section: Antimicrobial Resistancementioning

confidence: 93%

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Population structure and antimicrobial susceptibility of Mycoplasma ovipneumoniae isolates in France

Jaý

Ambroset

Tricot

et al. 2020

Veterinary Microbiology

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Section: Antimicrobial Resistancesupporting

confidence: 92%

Section: Antimicrobial Resistancementioning

confidence: 93%

Population structure and antimicrobial susceptibility of Mycoplasma ovipneumoniae isolates in France

Jaý

Ambroset

Tricot

et al. 2020

Veterinary Microbiology

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“…Currently, there are few global surveillance records for M. ovipneumoniae and some gaps in basic research have resulted from nutritionally limited conditions for in vitro growth (24–72 h with a peak at 48 h), a spherical morphology (pear, flask-shaped cells, and filaments), and a lack of fried egg-like morphology on agar plates [ 9 , 10 ]. After isolation, microbial identification mainly depends on additional tests such as biochemical testing, PCR, Sanger sequencing, serological testing, or matrix-assisted laser desorption/ionization-time of flight (MALDI-TOF) [ 1 , 11 – 13 ].…”

Section: Introductionmentioning

confidence: 99%

Mesomycoplasma ovipneumoniae from goats with respiratory infection: pathogenic characteristics, population structure, and genomic features

Peng

et al. 2023

BMC Microbiol

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Background Mycoplasma ovipneumoniae is a critical pathogen that causes respiratory diseases that threaten Caprini health and cause economic damage. A genome-wide study of M. ovipneumoniae will help understand the pathogenic characteristics of this microorganism. Results Toxicological pathology and whole-genome sequencing of nine M. ovipneumoniae strains isolated from goats were performed using an epidemiological survey. These strains exhibited anterior ventral lung consolidation, typical of bronchopneumonia in goats. Average nucleotide identity and phylogenetic analysis based on whole-genome sequences showed that all M. ovipneumoniae strains clustered into two clades, largely in accordance with their geographical origins. The pan-genome of the 23 M. ovipneumoniae strains contained 5,596 genes, including 385 core, 210 soft core, and 5,001 accessory genes. Among these genes, two protein-coding genes were annotated as cilium adhesion and eight as paralog surface adhesins when annotated to VFDB, and no antibiotic resistance-related genes were predicted. Additionally, 23 strains carried glucosidase-related genes (ycjT and group_1595) and glucosidase-related genes (atpD_2), indicating that M. ovipneumoniae possesses a wide range of glycoside hydrolase activities. Conclusions The population structure and genomic features identified in this study will facilitate further investigations into the pathogenesis of M. ovipneumoniae and lay the foundation for the development of preventive and therapeutic methods.

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“…However, the control of M. ovipneumoniae infection primarily relies on antimicrobial therapy because of its inherent resistance to cell wall-targeting antimicrobial drugs such as β-lactams and glycopeptide antibiotics. Oxytetracycline and macrolide antibiotics can alleviate clinical symptoms, but fail to eradicate the infection [56]. Notably, fluoroquinolones, tetracyclines, and macrolides have demonstrated efficacy in vitro to treat Mycoplasma pneumoniae [57].…”

Section: Discussionmentioning

confidence: 99%

Isolation and Characterization of Mycoplasma ovipneumoniae Infecting Goats with Pneumonia in Anhui Province, China

Chen,

Wang,

Dong

et al. 2024

Life

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Mycoplasma ovipneumoniae (M. ovipneumoniae) causes a fatal infection in goats, leading to significant economic losses in the small-ruminant industry worldwide. The present study aimed to characterize the strains of M. ovipneumoniae infecting goats with pneumonia in Anhui Province, China. From November 2021 to January 2023, among 20 flocks, a total of 1320 samples (600 samples of unvaccinated blood, 400 nasal swabs, 200 samples of pleural fluid, and 120 samples of lung tissue) were obtained from goats with typical signs of pneumonia, such as a low growth rate, appetite suppression, increased temperature, discharge from the nose, and a cough. Necropsied goats showed increased pleural fluid, fibrinous pleuropneumonia, and attached localized pleural adhesions. M. ovipneumoniae isolated from the samples were subjected to an indirect hemagglutination test (IHA), PCR amplicon sequencing, phylogenetic analysis, and biochemical identification tests. The overall positivity rate of M. ovipneumoniae was 27.50%. Mycoplasmas were obtained from 80 (20.0%) nasal swabs, 21 (10.5%) pleural fluid samples, and 15 (12.5%) lung samples. PCR amplicon (288 bp) sequencing identified eight strains of M. ovipneumoniae. In a phylogenetic tree, the isolated strains were homologous to the standard strain M. ovipneumoniae Y-98 and most similar to M. ovipneumoniae FJ-SM. Local strains of M. ovipneumoniae were isolated from goats in Anhui province. The identified genomic features and population structure will promote further study of M. ovipneumoniae pathogenesis and could form the basis for vaccine and therapy development.

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Antimicrobial Susceptibility of Caprine and Ovine Mycoplasma ovipneumoniae Isolates

Cited by 8 publications

References 16 publications

Population structure and antimicrobial susceptibility of Mycoplasma ovipneumoniae isolates in France

Population structure and antimicrobial susceptibility of Mycoplasma ovipneumoniae isolates in France

Mesomycoplasma ovipneumoniae from goats with respiratory infection: pathogenic characteristics, population structure, and genomic features

Isolation and Characterization of Mycoplasma ovipneumoniae Infecting Goats with Pneumonia in Anhui Province, China

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