Antimicrobial Susceptibility of Bacteria Isolated from Orthopedic Implants following Revision Hip Surgery

Tunney, Michael; Ramage, Gordon; Patrick, Sheila; Nixon, James R.; Murphy, Philip G.; Gorman, Seán

doi:10.1128/aac.42.11.3002

Cited by 110 publications

(58 citation statements)

References 11 publications

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“…They suggested that peptide antibiotics alone or in combination with other antibiotics (polymyxin B nonapeptide and novobiocin) may provide longer periods of protection against a wide range of bacterial pathogens. This finding is supported by an in vitro study [22] showing that vancomycin and ciprofloxacin were more active against 49 isolates recovered from orthopaedic implant infections than gentamicin. Case reports also show an effectiveness of vancomycin-impregnated PMMA beads in cases of methicillin-resistant S. aureus (MRSA) implant infections [16].…”

Section: Discussionsupporting

confidence: 77%

In vitro adherence and accumulation of Staphylococcus epidermidis RP 62 A and Staphylococcus epidermidis M7 on four different bone cements

König

Schierholz

Hilgers

et al. 2001

Langenbeck's Archives of Surgery

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Bacterial resistance of Staphylococcus epidermidis, a serious pathogen of implant-related infections, to antibiotics is related to the production of a glycocalyx slime that impairs antibiotic access and the killing by host defense mechanisms. In vitro studies of different bone cements containing antibiotics, developed for the prevention of biomaterial-associated infection, could not always demonstrate complete eradication of biomaterial-adherent bacteria. We have investigated four different bone cements in regard to bacterial accumulation of a slime-producing strain RP 62 A and its isogenic mutant M7 lacking the ability to produce exopolysaccharide slime using a bacterial adhesion assay and modified Kirby-Bauer technique. A significant effect of exopolysaccharide production for the accumulation on bone cement could be demonstrated. The gentamicin/clindamycin bone cement was the only tested biomaterial that produced a large zone of bacterial inhibition in the inoculated area adjacent to the biomaterial. The bacterial adhesion was not reduced significantly and there was no correlation between zones of inhibition on blood agar plates and the quantitative adhesion assay. The clinical efficacy of the gentamicin/clindamycin bone cement must be proven in vivo.

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Section: Discussionsupporting

confidence: 77%

In vitro adherence and accumulation of Staphylococcus epidermidis RP 62 A and Staphylococcus epidermidis M7 on four different bone cements

König

Schierholz

Hilgers

et al. 2001

Langenbeck's Archives of Surgery

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“…Megaprosthesis infections typically are low-organismburden, the pathogenesis of which is related to bacteria harbored by biofilms [21]. The megaprostheses may be colonized by bacteria at the time of implantation, either through direct inoculation or by airborne contamination of the incision [22], or later through hematogenous seeding or contiguous spread [23].…”

Section: Discussionmentioning

confidence: 99%

Infected Prostheses after Lower-Extremity Bone Tumor Resection: Clinical Outcomes of 100 Patients

Mavrogenis

Pala

Angelini

et al. 2015

Surgical Infections

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Megaprosthesis reconstructions may be infected in 8.6% of cases. Infections more commonly occur late, caused usually by S. epidermidis. The survival rate is higher with cementless megaprosthesis reconstructions and no different with respect to the type of tumor or megaprosthesis or the adjuvant treatments. One-stage revision is effective for acute post-operative infections; however, two-stage revision surgery is necessary for early and late infections. The rate of amputation because of occurrence or persistence of megaprosthesis infection is 21%.

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“…57 For implants not suspected of infection (i.e., aseptic loosening), sonication and enrichment culture of operative samples have shown that 22 percent of these implants grew bacteria. 28 The most common pathogens were Staphylococcus epidermidis and Propionibacterium acnes.…”

Section: Prosthetic Jointsmentioning

confidence: 99%

The Role of Bacterial Biofilms in Device-Associated Infection

Deva

Adams

Vickery

2013

Plastic and Reconstructive Surgery

221

121

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There is increasing evidence that bacterial biofilm is responsible for the failure of medical devices, leading to device-associated infection. As plastic surgeons, we are among the leading users of prostheses in surgery, and it is important that we are kept informed of this growing problem. This article summarizes the pathogenesis of device-associated infection, outlines the evidence for such infection in a number of medical devices, and outlines operative strategies aimed at reducing the risk of bacterial contamination at the time of device deployment. It also outlines strategies under investigation to combat the development of device-associated infection.

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Antimicrobial Susceptibility of Bacteria Isolated from Orthopedic Implants following Revision Hip Surgery

Cited by 110 publications

References 11 publications

In vitro adherence and accumulation of Staphylococcus epidermidis RP 62 A and Staphylococcus epidermidis M7 on four different bone cements

In vitro adherence and accumulation of Staphylococcus epidermidis RP 62 A and Staphylococcus epidermidis M7 on four different bone cements

Infected Prostheses after Lower-Extremity Bone Tumor Resection: Clinical Outcomes of 100 Patients

The Role of Bacterial Biofilms in Device-Associated Infection

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