Antimicrobial Susceptibility and Molecular Typing of<i>Salmonella</i>Agona Isolated from Humans and Other Sources

Kuang, Dai; Zhang, Jianmin; Meng, Jianghong; Yang, Xiaowei; Jin, Huang; Shi, Weimin; KaiJian, Luo; Yan, Tao; Pan, Hongyu; Xu, Xuebin; Ren, Tao

doi:10.1089/fpd.2014.1776

Cited by 6 publications

(3 citation statements)

References 25 publications

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“…This serovar was first reported in Ghana, isolated from cattle, and appeared as a public health challenge in the late 1960s in the United States, Europe, and Israel. Kuang et al (150) reported that S. Agona is ranked among the top 10 serovars that cause human diarrheal diseases in China. In addition, these authors reported that most isolates were susceptible to antibacterial drugs and noted that the PFGE pattern indicated an association between isolates from humans and different animal-based foods.…”

Section: Discussionmentioning

confidence: 99%

Worldwide Epidemiology ofSalmonellaSerovars in Animal-Based Foods: a Meta-analysis

Ferrari

Rosário

Neto

et al. 2019

Appl Environ Microbiol

391

264

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Salmonella spp. are among the most important foodborne pathogens and the third leading cause of human death among diarrheal diseases worldwide. Animals are the primary source of this pathogen, and animal-based foods are the main transmission route to humans. Thus, understanding the global epidemiology of Salmonella serovars is key to controlling and monitoring this bacterium. In this context, this study aimed to evaluate the prevalence and diversity of Salmonella enterica serovars in animalbased foods (beef, pork, poultry, and seafood) throughout the five continents (Africa, the Americas [North and Latin America], Asia, Europe, and Oceania). The meta-analysis consisted of a chemometric assessment (hierarchical cluster analysis and principal component analysis) to identify the main epidemiological findings, including the prevalence and diversity of the Salmonella serovars in each matrix. Regarding the serovar distribution, S. Typhimurium presented a cosmopolitan distribution, reported in all four assessed matrices and continents; poultry continues to play a central role in the dissemination of the Enteritidis serovar to humans, and Anatum and Weltevreden were the most frequently found in beef and seafood, respectively. Additionally, we recommended careful monitoring of certain serovars, such as Derby, Agona, Infantis, and Kentucky. Finally, given the scientific data regarding the most frequently reported serovars and which matrices constitute the main vehicles for the transmission of this pathogen, control programs may be improved, and specific interventions may be implemented in an attempt to reduce the risk of this pathogen reaching humans. IMPORTANCE Salmonellosis is caused by Salmonella spp. and is the third leading cause of death among food-transmitted diseases. This pathogen is commonly disseminated in domestic and wild animals, and the infection's symptoms are characterized by acute fever, nausea, abdominal pain, and diarrhea. The animals are the primary source of salmonellae, and animal-based foods are the main transmission route to humans. Therefore, data collected from these sources could contribute to future global interventions for effective control and surveillance of Salmonella along the food chain. In light of this, the importance of our research is in identifying the prevalence of Salmonella serovars in four animal-based food matrices (pork, poultry, beef, and seafood) and to evaluate the importance that each matrix has as the primary source of this pathogen to humans.

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Section: Discussionmentioning

confidence: 99%

Worldwide Epidemiology ofSalmonellaSerovars in Animal-Based Foods: a Meta-analysis

Ferrari

Rosário

Neto

et al. 2019

Appl Environ Microbiol

391

264

View full text Add to dashboard Cite

show abstract

“…Minnesota are MDR strains, which is in line with similar observations by others for serotypes like S . Agona (Kuang et al, 2014; Irfan et al, 2015), S . Kentucky (Le Hello et al, 2013; Seiffert et al, 2014), and S .…”

Section: Discussionmentioning

confidence: 99%

S. Enteritidis and S. Typhimurium Harboring SPI-1 and SPI-2 Are the Predominant Serotypes Associated With Human Salmonellosis in Saudi Arabia

Alghoribi

Doumith

Alrodayyan

et al. 2019

Front. Cell. Infect. Microbiol.

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Non-typhoidal Salmonella (NTS) strains are Gram negative bacterial pathogens that are associated with foodborne illness worldwide. During the process of infection, Salmonella uses two molecular injectisomes known as Type 3 Secretion Systems (T3SS) to secrete virulence factors that are encoded by Salmonella Pathogenicity Island-1 (SPI-1) and SPI-2 into host cells. These secretion systems play a major role in virulence, as shown in various animal models, but little is known about their role in human infections. In Saudi Arabia, NTS strains frequently cause human infections but data regarding these pathogenic strains is fairly limited. The aim of this study was to characterize Salmonella human clinical isolates in Riyadh, Saudi Arabia, by determining their serotype, testing for the presence of SPI-1 and SPI-2 genes and to determine the antibiotic resistance profiles of these strains. Using the rapid Check and Trace Salmonella ™ (CTS) system our results demonstrate that S . Enteritidis and S . Typhimurium were the predominant serovars, followed by S . Livingstone, S . Kentucky and S . Poona among a list of 36 serovars reported for the first time in the country. In addition, SPI-1 genes were detected in 99% of the isolates, while the sifA gene (SPI-2) was not detected in 13.5% of the isolates. These results suggest that both the SPI-1 and SPI-2 virulence determinants are important for human infection. Moreover, we report the presence of a Multi-Drug (MDR) carbapenem resistant S . Kentucky isolate harboring the bla OXA−48 gene not reported previously in Saudi Arabia.

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“…In addition to overall AMR prevalence, many studies compared the phenotypes and/or genotypes of isolates from different locations or sources, to address whether food could be the source of ARB for consumers. In studies based on a limited number of ARGs, virulence genes and/or phenotypes, the authors often interpreted the data to show similarity between human clinical samples and samples from food or food animals (Abdeen et al, 2021 ; Dutil et al, 2010 ; Gormley et al, 2010 ; Kuang et al, 2014 ; Overdevest, 2011 ). By contrast, studies using higher resolution methods based on whole-genome sequencing often revealed divergence between human and foodborne isolates (Acar et al, 2017 ; Campos et al, 2019 ; Cummins et al, 2022 ; Keefer et al, 2019 ; Lee et al, 2021 ).…”

Section: Resultsmentioning

confidence: 99%

Contribution of Food to the Human Health Burden of Antimicrobial Resistance

Kujat Choy,

Neumann,

Romero-Barrios

et al. 2024

Foodborne Pathogens and Disease

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The impact of foodborne antimicrobial resistance (AMR) on the human health burden of AMR infections is unknown. The aim of this review was to evaluate and summarize the scientific literature investigating all potential sources of human AMR infections related to food. A literature search was conducted in Embase (Ovid) and MEDLINE (Ovid) databases to identify appropriate studies published between 2010 and 2023. The results of the search were reviewed and categorized based on the primary subject matter. Key concepts from each category are described from the perspective of food safety as a public health objective. The search yielded 3457 references, 1921 remained after removal of duplicates, abstracts, editorials, comments, notes, retractions, and errata. No properly designed source attribution studies were identified, but 383 journal articles were considered relevant and were classified into eight subcategories and discussed in the context of four streams of evidence: prevalence data, epidemiological studies, outbreak investigations and human health impact estimates. There was sufficient evidence to conclude that AMR genes, whether present in pathogenic or nonpathogenic bacteria, constitute a foodborne hazard. The level of consumer risk owing to this hazard cannot be accurately estimated based on the data summarized here. Key gaps in the literature are noted.

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Antimicrobial Susceptibility and Molecular Typing ofSalmonellaAgona Isolated from Humans and Other Sources

Cited by 6 publications

References 25 publications

Worldwide Epidemiology ofSalmonellaSerovars in Animal-Based Foods: a Meta-analysis

Worldwide Epidemiology ofSalmonellaSerovars in Animal-Based Foods: a Meta-analysis

S. Enteritidis and S. Typhimurium Harboring SPI-1 and SPI-2 Are the Predominant Serotypes Associated With Human Salmonellosis in Saudi Arabia

Contribution of Food to the Human Health Burden of Antimicrobial Resistance

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