Antimicrobial Susceptibility and Clinical Findings of Anaerobic Bacteria

Cobo, Fernando

doi:10.3390/antibiotics11030351

Cited by 3 publications

(2 citation statements)

References 19 publications

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“…This pattern was different from the sensitivity pattern reported by Osaro-matthew et al [11], in which E. coli was most sensitive to ceftriazone (96.4%), Staphylococcus aureus was most sensitive to gentamycin (100%), Coagulase negative staphylococcus Species was most sensitive to ofloxacin and peflacin (100%), while Klebsiella species was most sensitive to ofloxacine, peflacin, ceftriaxone, gentamycin, ceporex (100%). This shows that the antibiotic sensitivity pattern of bacterial pathogens is constantly evolving, hence the need for continuous antibiotic sensitivity pattern monitoring and surveillance to combat the menace of emergence and re-emergence of antibiotic resistance as recommended by past studies [23][24][25].…”

Section: Medpress Public Health and Epidemiologymentioning

confidence: 99%

Bacterial Pathogens Associated With Eyeglasses and Risks of Infection among Staff and Students of a Private University in South–West Nigeria

Enitan¹,

Edafetanure–Ibeh²,

Itodo³

et al. 2022

MPPHE

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Section: Medpress Public Health and Epidemiologymentioning

confidence: 99%

Bacterial Pathogens Associated With Eyeglasses and Risks of Infection among Staff and Students of a Private University in South–West Nigeria

Enitan¹,

Edafetanure–Ibeh²,

Itodo³

et al. 2022

MPPHE

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“…They can cause endogenous infections when the immune system is compromised or mucosal barriers are damaged [1]. Often, these infections are mixed, with multiple anaerobic and aerobic bacterial species present [2]. These infections can be life-threatening, so appropriate antimicrobial therapy is life-saving [3].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Susceptibility Profile of Rare Anaerobic Bacteria

Wolf

Stingu

2022

Antibiotics

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Anaerobes play an important role in clinically relevant infections and resistance is increasing worldwide. We tested 120 rare anaerobic isolates belonging to 16 genera for antimicrobial resistance using the agar dilution method and compared those results to the time-saving E-test method. The susceptibility data for 12 antimicrobial substances (benzylpenicillin, ampicillin/sulbactam, piperacillin/tazobactam, imipenem, meropenem, cefoxitin, metronidazole, moxifloxacin, clindamycin, doxycycline, tigecycline, eravacycline) were collected. Susceptibility testing showed low resistance to β-lactam/β-lactamase inhibitor combinations and no resistance to carbapenems and tigecycline. We observed moderate to high rates of resistance to moxifloxacin and clindamycin which differed depending on the methodology used. The essential and categorical agreement was over 90% for ampicillin/sulbactam, meropenem, moxifloxacin, and tigecycline. For metronidazole and clindamycin, the essential agreement was below 90% but the categorical agreement was near or above 90%. Penicillin presented with the lowest categorical agreement of 86.7% and a very high very major error rate of 13.3%. The resistance rates reported in this study are concerning and show the importance of routine susceptibility testing. Further investigations are necessary to determine the reason for high error rates and how to improve susceptibility testing of fastidious anaerobes.

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Anaerobic Profile of Intra-abdominal Infections – A 23-Year Retrospective Study

Chetty¹,

Biswas²,

Sistla³

et al. 2023

J. Pure Appl. Microbiol.

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Obligate anaerobes, which are part of normal intestinal flora are now gaining pathogenic potential by becoming more virulent and causing moderate to severe abdominal infections. Moreover, there is delay in initiation of appropriate antimicrobial therapy. The study aimed to describe and analyse 23 years data on anaerobic intra – abdominal infections in regards to the distribution and antimicrobial susceptibility patterns of the obligate anaerobes which were isolated from various intra – abdominal infections. The demographic and microbiological data was retrieved from the microbiology departmental registers. Total number of cases/specimen were 1124. Bacteroides fragilis group (238) (56%) and Peptostreptococcus sp (109) (25%) amounted to the majority of the isolates. Rare anaerobes like Clostridium sporogenes, Propionibacterium sp, Clostridium bifermentans and Fusobacterium varium were also isolated. Majority of mixed anaerobic infections were contributed by Bacteroides fragilis group and Peptostreptococcus sp (99) out of 102 mixed anaerobic infections). Chronic alcoholism was the most common predisposing condition (p value <0.05). Among the antimicrobials which were used by the clinicians for treating the infection, only Metronidazole was tested for its susceptibility pattern. One isolate was resistant to metronidazole (Diameter of inhibition zone was 6 mm). As they are fastidious they usually go unnoticed. Hence, this descriptive study intends to bring light on the large number of various obligate anaerobes and the potential diseases that they can cause and also the need for their antibiotic susceptibility testing to look for antimicrobial resistance among the isolates.

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Antimicrobial Susceptibility and Clinical Findings of Anaerobic Bacteria

Abstract: Anaerobic microorganisms are the most abundant components of the normal human microbiota; they colonize mucous membranes such as the oral cavity and the gastrointestinal and female genital tracts, and they are common pathogens in human populations [...]

Cited by 3 publications

References 19 publications

Bacterial Pathogens Associated With Eyeglasses and Risks of Infection among Staff and Students of a Private University in South–West Nigeria

Bacterial Pathogens Associated With Eyeglasses and Risks of Infection among Staff and Students of a Private University in South–West Nigeria

Antimicrobial Susceptibility Profile of Rare Anaerobic Bacteria

Anaerobic Profile of Intra-abdominal Infections – A 23-Year Retrospective Study

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