Antimicrobial susceptibilities of Porphyromonas and Prevotella species isolated from periodontitis infections in the north of Portugal

Piña, Cristina; Cunha, Sílvio; Silva, Ricardo; Sousa, Jailson Carmo de; Cardoso, Inês Lopes

doi:10.1142/9789814405041_0099

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“…Most resistance genes were found in strains previously identified as P. intermedia. This strain together with P. gingivalis are commonly isolated from periodontal infections being considered the most abundant putative black pigmented species [2,4,9,11,18]. When considering isolates from patients with periodontal disease, Prevotella sp.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of antibiotic (β-lactams, tetracycline, metronidazole, erythromycin) resistance genes in periodontic infections

Freitas¹,

Gonçalves²,

Coelho³

et al. 2019

Clin Res Trial

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Objective: Porphyromonas gingivalis and Prevotella intermedia are thought to be pathogens in adult periodontitis. Antibiotherapy is usually needed in the treatment of periodontitis being often prescribed empirically. To allow prescription of a specific antibiotic treatment, identification of resistance genes should be performed. The aim of this study was the identification of the presence of TetM, TetQ, TEM, cfxA, MefA, ErmB and Nim resistance genes in previously identified P. intermedia and P. gingivalis isolated from samples collected from periodontal infections.Method: PCR was used for the identification of TetM, TetQ, TEM, cfxA, MefA, ErmB and Nim resistance genes in strains isolated from samples collected from periodontal infections.Results: It was seen that 8% of isolates had one of the tested tetracycline resistance genes. A total of 32% of β-lactamases resistance genes was observed in isolated strains. It was also observed that 2% of isolates had one of the analysed erythromycin resistance genes. None of the isolates showed the presence of the metronidazole resistance gene. Conclusions:Most strains harboring β-lactamase resistance genes had been previously identified as P. intermedia. No tetracycline resistance gene and a very low percentage of β-lactamase resistance genes were observed in P. gingivalis strains.

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Section: Discussionmentioning

confidence: 99%