Antimicrobial Substances From Sponges

Jakowska, Sophie; Nigrelli, Ross F.

doi:10.1111/j.1749-6632.1960.tb26436.x

Cited by 46 publications

(3 citation statements)

References 6 publications

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“…The synthetic symmetric macrocycles H 4 pat 1-3 and the natural peptide ascidiacyclamide have comparable distances of their N het atoms but a strikingly different orientation of the heterocycles. The higher rigidity of the imidazoles of H 4 pat 1 in combination with an alternating configuration at C α leads to a somewhat more shielded cavity of H 4 pat 1 , compared to those of H 4 asc, H 4 patD, and H 4 pat 2,3 . H 4 asc and H 4 patD have a stronger twist of the heterocycles which enlarges the accessibility of the cavity, while the identical configuration at all C α sites in H 4 pat 2 and H 4 pat 3 leads to a shielded and an unshielded side of the macrocycle.…”

Section: Michael Westphalmentioning

confidence: 99%

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Cyclic peptide marine metabolites and Cu^II

et al. 2014

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a Cyclic pseudo-peptides derived from marine metabolites of the genus Lissoclinum bistratum and Lissoclinum patella have attracted scientific interest in the last two decades. Their structural properties and solution dynamics have been analyzed in detail, elaborate synthetic procedures for the natural products and synthetic derivatives developed, the biosynthetic pathways studied and it now is possible to produce them biosynthetically. Initially, these macrocyclic ligands were studied due to their medicinal and pharmaceutical potential -some of the isolated cyclic pseudo-peptides show high cytotoxic and antiviral activity.A major focus in the last decade has been on their Cu II coordination chemistry, as a number of studies have indicated that dinuclear Cu II complexes of cyclic peptides may be involved in the ascidians' metabolism, and this is the focus of the present review.

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Section: Michael Westphalmentioning

confidence: 99%

“…The interest in molecules from marine organisms increased considerably in the 1960s, when numerous metabolites were found to have excellent antiviral and cytotoxic properties. [1][2][3][4][5][6] In just 10 years (between 1977 and…”

Section: Introductionmentioning

confidence: 99%

Cyclic peptide marine metabolites and Cu^II

et al. 2014

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“…Many of the bacteria infecting Chondrilla nucula in the Mediterranean were found to possess damaged cell walls, suggesting the presence of an active sponge defence mechanism (Gaino and Pronzato, 1987). There are also reports of sponge products which are able to inactivate pathogenic bacteria (Nigrelli et al ., 1959; Jakowska and Nigrelli, 1960). Brominated compounds with antibiotic properties have been localized within spherulous cells of Aplysina fistularis and appear to play a role in reducing surface fouling (Thompson et al ., 1983).…”

Section: Infection and Defence Mechanismsmentioning

confidence: 99%

Sponge disease: a global threat?

Webster¹

2007

Environmental Microbiology

195

164

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SummarySponges are the most simple and primitive metazoans, yet they have various biological and ecological properties that make them an influential component of coral-reef ecosystems. Marine sponges provide refuge for many small invertebrates and are critical to benthic-pelagic coupling across a wide range of habitats. Reports of sponge disease have increased dramatically in recent years with sponge populations decimated throughout the Mediterranean and Caribbean. Reports also suggest an increased prevalence of sponge disease in Papua New Guinea, the Great Barrier Reef and in the reefs of Cozumel, Mexico. These epidemics can have severe impacts on the survival of sponge populations, the ecology of the reef and the fate of associated marine invertebrates.

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