Antimicrobial study of polymeric ligands derived from 2, 4-dihydroxy acetophenone and their lanthanide (III) polychelates

Abstract

In the present work, antimicrobial activities of five polymeric ligands derived from 2,4-dihydroxy acetophenone (DHAP-ED, DHAP-1,2 PD, DHAP-1,3 PD, DHAP-1,3 BD and DHAP-1,4 BD) and its polychelates with La3+, Pr3+, Nd3+, Sm3+, Gd3+, Tb3+ and Dy3+ have been studied. Agar diffusion method has been used to determine antimicrobial activity, and the organisms used were Escherichia coli, Bacillus substilis, Staphylococcus aureus (bacteria) and Sanccharomyces cerevisiae (yeast). Some important aspects viz. effect of pH, size of inoculums, and choice and ingredient of culture media were also taken into consideration while assessing the antimicrobial activities. From the results it was indicated that the polychelates possess higher antimicrobial activity compared to polymeric ligands primarily due to sharing of electron and increased lipophilicity of the polychelates.