Antimicrobial studies of newly synthesized organotin(IV) complexes of dihydrobis(2-mercaptothiazolinyl)borate

Joshi, Rajkumar; Ahmad, Naushad; Khan, Salman A.; Hashmi, Athar Adil

doi:10.1080/00958971003649690

Cited by 8 publications

(3 citation statements)

References 41 publications

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“…The molar conductivities of metal complexes show that compounds 1 and 2 have no electrolytic nature while compound 3, indicates that it is 1:1 electrolytes. By the infrared spectral data, the coordination was confirmed by comparing the infrared spectrum of the ligand and its derivative complexes Compared to the ligand bands, [34][35][36] variations in the wave number in C=S band were observed for all complexes, indicating a weakening of the bond involved in coordination and the presence of metal coordinated to the sulfur atom of the C=S (Table 1). Instead, the band corresponding to νB-N in complexes 2 and 3 was shifted to higher frequencies opposite the free ligand, indicating that the coordination affects the B-N bond (Table 1).…”

Section: Resultsmentioning

confidence: 99%

SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF NEW Cu (II), Co (II) AND Sn (II) COMPLEXES WITH THE SODIUM HYDROTRIS(2-MERCAPTOTHIAZOLYL)BORATE LIGAND

Ferreira¹,

Andrade²,

Lima³

et al. 2020

Quim. Nova

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Recebido em 27/11/2019; aceito em 05/02/2020; publicado na web em 16/04/2020 The emergence of antibiotic resistance among microbial pathogens is a serious public health problem, resulting in a constant need of discovering new antibiotics. For this purpose, we synthetized and determined the antimicrobial activity of copper (Cu), cobalt (Co), and tin (Sn) complexes coordinated with scorpionate ligand in a tridentate mode against microorganisms of clinical importance. New complexes with the sodium hydrotris(2-mercaptothiazolyl)borate ligand were characterized by physicochemical and spectroscopic techniques (UV-vis, IR, 1 H and 13 C NMR). Moreover, their antimicrobial activity was evaluated using microdilution broth method. Cytotoxicity was determined in Vero cells and the selectivity index (SI) was calculated. The coordination with metals increased the ligand antimicrobial activity, which showed no activity when evaluated alone (MIC>1,080 µM). Cu-complex (1) had activity against Candida albicans and C. krusei, with MICs of 130 and 66 µM, respectively. The compounds had low toxicity on Vero cells and chemo-informatics assays corroborated a low systemic toxic effect. The SI revealed that the compound 1 was 16 times more selective for C. krusei and 8 times more selective for C. albicans in relation to Vero cells. The Cu-complex stands out as a potential prototype for the development of new antifungal agents.

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Section: Resultsmentioning

confidence: 99%

SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF NEW Cu (II), Co (II) AND Sn (II) COMPLEXES WITH THE SODIUM HYDROTRIS(2-MERCAPTOTHIAZOLYL)BORATE LIGAND

Ferreira¹,

Andrade²,

Lima³

et al. 2020

Quim. Nova

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“…The ligands thus obtained were designated as SM, SIP, PM, and PIP, respectively. (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12) were prepared by treating 2 mol of half-esters (ligands) with 1 mol of dialkyltin dichloride using Scheme 2.…”

Section: Synthesismentioning

confidence: 99%

“…Organotin complexes can be powerful fungicides and bactericides, depending on the constituent organic group and ligands [2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Diorganotin complexes of carboxylates: synthesis and characterization

Chilwal

Deep

Malhotra

et al. 2013

Journal of Coordination Chemistry

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Diorganotin complexes of monoisopropyl and monomethyl nadiate, succinate, and phthalate were synthesized and characterized by elemental analysis, FT-IR, 1 H NMR, 13 C NMR, and 119 Sn NMR spectroscopic techniques. The spectroscopic investigation demonstrated that carboxylate is bidentate in the diorganotin complexes. On the basis of 1 J( 119 Sn-13 C) and 2 J( 119 Sn-1 H) values, C-Sn-C bond angles were also calculated. The newly synthesized complexes were also screened for their antibacterial activities against Gram-positive and Gram-negative pathogenic strains of bacteria.

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