Antimicrobial sensitivity pattern of organisms causing urinary tract infection in children with sickle cell anemia in Maiduguri, Nigeria

Abstract

Etiological agents of childhood urinary tract infections (UTI) in this environment are resistant to most of the drugs commonly recommended for its treatment. Amoxicillin/clavulanic acid, cefuroxime, and gentamicin, are recommended as first-line drugs for treatment of UTI while awaiting results of culture and sensitivity. Ceftriaxone and ceftazidime should be reserved for case of non response to first-line drugs and severe infections.

Antibiotic sensitivity pattern of bacteria isolated from Nigerian currencies (Naira) circulating in some hospitals of Kano metropolis, Kano state, Nigeria

“…(2013).Ciprofloxacin a quinolone compound which act by inhibiting nucleic acid synthesis can be considered as a drug of choice against bacteria associated with nosocomial infections. The high level of resistance exhibited by the isolates to β lactam antibiotics conform with the work of Nwanko et al (2017) which could be as a result of the production of β lactamase enzyme that render the drugs ineffective (Mava et al,2011). Table 5 revealed that 38 out of 355 isolates were MDR (16% from hospital isolates while 6% from non hospital currency notes P<0.005).…”

Bacteriology of urinary tract infection and antimicrobial sensitivities in under-five children in Enugu

“…The flouroquinolones showed better sensitivities against the pathogens as was observed in other studies 6,8,9,11,18,26,27 In Maiduguri, 11 Benin 8 and Ilorin, 18 more than 80% of the E. coli isolates was sensitive to ciprofloxacin. S. aureus was 100% sensitive to this drug in Maiduguri.…”

“…Table 2 shows the distribution of the various isolates according to sex. 7,8,9,11,17,18 . However while E. coli was the most common organism causing UTI in our series as was also reported in Benin 8 and Maiduguri, 9 Klebsiella was the dominant organism isolated in studies in Portharcourt, 5 Ibadan 17 and Abakiliki 7 .…”

“…While Escherichia coli was the most common urinary isolate in studies in Benin 8 and Maiduguri 9 , Klebsiella predominated in studies in Port Harcourt 5 Ibadan 6 and Abakiliki 7 . Also the antimicrobial resistance rates among uropathogens is on the increase thus limiting therapeutic options 7,10,11 . The rate and man-ner of resistance varies with the setting either in developing or developed countries.…”

Antibacterial Sensitivities of Urinary Pathogenes among Children with Sickle Cell Anaemia in a Tertiary Hospital

“…These findings were similar to those reported by others. 14,15 The explanation for this high sensitivity of this urinary isolates to this drugs in this study may be due to the fact that, in this environment, most parents cannot afford this drug even when prescribed and this may lead to low drug pressure and high sensitivity.…”