Antimicrobial screening of ethnobotanically important stem bark of medicinal plants

Singh, Meenakshi; Khatoon, Sayyada; Singh, Shweta; Kumar, V. Bharath; Rawat, Ajay Kumar Singh; Mehrotra, Shanta

doi:10.4103/0974-8490.69127

Cited by 18 publications

(6 citation statements)

References 4 publications

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“…Ethanol extraction shows little increase in the yield percentage, zone of inhibition of ethanol extract shows little increase than methanol extract when treated with different micro organisms and Methanol extraction which we have done for comparative studies for our knowledge Doughari and Manzara [9] found that both acetone and methanol extracts inhibited the growth of gram positive bacteria, with acetone extract exerting more activities on all the gram positive bacteria with zone of inhibition between 15 -16 mm, and a gram negative bacterium Salmonella typhi (14 mm) at 250 mg/mL. Singh [10] extracted stem park of M. indica and excellent results have been generated with significant antibacterial and antifungal activities (MIC = 0.08 mg/mL) against Streptococcus pneumonia, Enterobacter aerogenes, Klebsiella pneumonia and Candida albicans. In the present study encouraging results have been produced with both ethanolic and methanolic extracts but interestingly with the seeds of mango.…”

Section: Discussionmentioning

confidence: 99%

“…Doughari and Manzara [9] found that both acetone and methanol extracts inhibited the growth of gram positive bacteria, with acetone extract exerting more activities on all the gram positive bacteria with zone of inhibition between 15 -16 mm, and a gram negative bacterium S. typhi (14 mm) at 250 mg/mL. Stem park of M. indica showed significant antibacterial and antifungal activities against Streptococcus pneumonia, Enterobacter aerogenes, Klebsiella pneumonia and Candida albicans with MIC of 0.08 mg/mL [10].…”

Section: Introductionmentioning

confidence: 99%

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Antimicrobial Activities of Seed Extracts of Mango (<i>Mangifera indica</i> L.)

El-Gied¹,

Joseph²,

Mahmoud³

et al. 2012

AiM

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Mangifera indica L. is a species of mango in the Anacardiaceae family. It is found in the wild in tropical regions and cultivated varieties have been introduced to other warm regions of the world. This present study aimed to investigate the in vitro antimicrobial activities of methanol and ethanol extracts of mango seed against 25 representatives gram positive, gram negative, acid fast bacteria and fungi. Mango fruit seed were extracted by Soxhlet using methanol and ethanol as solvents. The extracts were tested against the microorganisms using disc diffusion method at different concentrations: 5 mg/mL, 3.75 mg/mL, 3.125 mg/mL, 2.5 mg/mL, 1.875 mg/mL and 1.25 mg/mL). In vitro antibacterial activities of methanol and ethanol extracts of mango bulb showed inhibitions to tested organisms with variable inhibition zones. Except one organism (Rhodococcus equi), no resistance among the tested strains was shown. The mean zone of inhibition produced ranged between 5 mm and 18 mm with 18 mm/Mycobacterium smegmatis showed the highest zone of inhibition. In most test strains comparable zones of inhibitions were noted for both methanol and ethanol extract. Candida albicans and Aspergilllus niger were both inhibited by the extracts. The methanol and ethanol extracts of mango seed showed good inhibitory effects against almost all tested strains. The inhibition zones produced by mango extract were less than those produced by standard positive control drug. This could be due to low diffusion rate of mango extract in agarose medium, a thing needed to be further investigated. The products are potential new antimicrobial therapy in the ethnopharmacology domain.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antimicrobial Activities of Seed Extracts of Mango (<i>Mangifera indica</i> L.)

El-Gied¹,

Joseph²,

Mahmoud³

et al. 2012

AiM

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“…Approximately 200 species have been identified from this genus [ 23 ]. This genus exhibited antifungal [ 24 – 27 ], antibacterial [ 25 , 27 ], anti-inflammatory [ 28 ], antiallergic effects [ 28 ], insect antifeedant [ 29 ], piscicide [ 30 ], and antioxidant activity [ 31 – 34 ].…”

Section: Introductionmentioning

confidence: 99%

Crude Ethanol Extract ofPithecellobium ellipticumas a Potential Lipid-Lowering Treatment for Hypercholesterolaemia

Wong

Wijaya

Ting

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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If left untreated, hypercholesterolaemia can lead to atherosclerosis, given time. Plants from the Fabaceae family have shown the ability to significantly suppress atherosclerosis progression. We selected four extracts from Pithecellobium ellipticum, from the Fabaceae family, to be screened in a 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase) assay. The ethanol extract, at a concentration of 500 μg/mL, exhibited superior inhibition properties over the other extracts by demonstrating 80.9% inhibition, while 0.223 μg/mL of pravastatin (control) showed 78.1% inhibition towards enzymatic activity. These findings led to the fractionation of the ethanol extract using ethyl acetate : methanol (95 : 5), gradually increasing polarity and produced seven fractions (1A to 7A). Fraction 7A at 150 μg/mL emerged as being the most promising bioactive fraction with 78.7% inhibition. FRAP, beta carotene, and DPPH assays supported the findings from the ethanol extract as it exhibited good overall antioxidant activity. The antioxidant properties have been said to reduce free radicals that are able to oxidize lipoproteins which are the cause of atherosclerosis. Phytochemical screenings revealed the presence of terpenoid, steroid, flavonoid, and phenolic compounds as the responsible group of compound(s), working individually or synergistically, within the extract to prevent binding of HMG-CoA to HMG-CoA reductase.

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“…[ 3 ] The massive use of plants is encouraged by their efficiency, their availability, and the low cost of herbal concoctions. [ 4 5 ] Although many plants have been screened with success for several biological activities,[ 6 – 9 ] some plants have proven very toxic. [ 10 11 ] Recently, our team identified some critical points in the plant processing and several risks related to the ingestion of contaminated herbal concoctions.…”

Section: Introductionmentioning

confidence: 99%

Medicinal plants use in central Togo (Africa) with an emphasis on the timing

Tchacondo¹,

Karou²,

Agban³

et al. 2012

Phcog Res

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Background:Plant-based remedies continue to play a key role in the health care of people in Togo; however, there is a lack of published data in medicinal plants and medical practices of the people in the country.Objective:This study was aimed at documenting the plant utilization in the Tem folk medicine in the central region of Togo.Materials and Methods:An ethnobotanical survey was conducted with traditional healers in the central region of Togo using a semi-structured questionnaire.Results:This study demonstrated that local specialists in the central region of Togo tend to agree with each other in terms of the plants used to treat diabetes (ICF = 0.38), infertility, and abdominal pains (ICF = 0.33), but cite a much more diverse groups of plants to treat problems related to arterial hypertension, sickle cell disease, and abscess. They use 144 herbal concoctions made of 72 plants, distributed among 36 botanical families. The Euphorbiaceae family with eight species was best represented in terms of the number of species. The species with the highest use value were Khaya senegalensis (Desr.) A. Juss. (Meliaceae) (UV = 0.36), Anthocleista djalonensis A. Chev. (Gentianaceae) (UV = 0.27), Trichilia emetica Vahl (Meliaceae) (UV = 0.25), and Sarcocephalus latifolius (Sm.) E. A. Bruce (Rubiaceae) (UV = 0.21). They also rely on the timing in the plant processing and the administration of herbal remedies.Conclusion:All these findings are based on empirical observations; laboratory screenings are needed to check the effectiveness of these plants.

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Antimicrobial screening of ethnobotanically important stem bark of medicinal plants

Cited by 18 publications

References 4 publications

Antimicrobial Activities of Seed Extracts of Mango (<i>Mangifera indica</i> L.)

Antimicrobial Activities of Seed Extracts of Mango (<i>Mangifera indica</i> L.)

Crude Ethanol Extract ofPithecellobium ellipticumas a Potential Lipid-Lowering Treatment for Hypercholesterolaemia

Medicinal plants use in central Togo (Africa) with an emphasis on the timing

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Antimicrobial screening of ethnobotanically important stem bark of medicinal plants

Cited by 18 publications

References 4 publications

Antimicrobial Activities of Seed Extracts of Mango (&lt;i&gt;Mangifera indica&lt;/i&gt; L.)

Antimicrobial Activities of Seed Extracts of Mango (&lt;i&gt;Mangifera indica&lt;/i&gt; L.)

Crude Ethanol Extract ofPithecellobium ellipticumas a Potential Lipid-Lowering Treatment for Hypercholesterolaemia

Medicinal plants use in central Togo (Africa) with an emphasis on the timing

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Antimicrobial Activities of Seed Extracts of Mango (<i>Mangifera indica</i> L.)

Antimicrobial Activities of Seed Extracts of Mango (<i>Mangifera indica</i> L.)