Antimicrobial Screening of Breynia nivosus and Ageratum conyzoides Against Dental Caries Organisms

Amadi, ES; Oyeka, C. A.; Onyeagba, R. A.; Ugbogu, Ositadinma Chinyere; Okoli, I. C.

doi:10.3923/jbs.2007.354.358

Cited by 16 publications

(5 citation statements)

References 14 publications

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“…These tests are usually rapid and can be carried out with minimal cost. Agar diffusion methods (disc diffusion or well diffusion) are popular and have been used in a number of studies [ 19 , 25 – 30 ]. These methods involve inoculation of the surface of an agar plate with the test micro-organism or pouring molten agar inoculated with the test organism into a Petri dish.…”

Section: Antimicrobial Assaysmentioning

confidence: 99%

“…Cold and hot water and ethanolic extracts of Breynia nivosus (Euphorbiaceae) and Ageratum conyzoides (Asteraceae) were tested for activity against S. mutans [ 30 ]. While the hot water and ethanol extracts (at >25 mg mL −1 ) of B. nivosus showed activity, none of the A. conyzoides extracts were active.…”

Section: Antibacterial Activity Of Crude or Total Plant Extractsmentioning

confidence: 99%

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Traditional Medicinal Plant Extracts and Natural Products with Activity against Oral Bacteria: Potential Application in the Prevention and Treatment of Oral Diseases

Palombo

2011

Evidence-Based Complementary and Alternative Medicine

442

350

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Oral diseases are major health problems with dental caries and periodontal diseases among the most important preventable global infectious diseases. Oral health influences the general quality of life and poor oral health is linked to chronic conditions and systemic diseases. The association between oral diseases and the oral microbiota is well established. Of the more than 750 species of bacteria that inhabit the oral cavity, a number are implicated in oral diseases. The development of dental caries involves acidogenic and aciduric Gram-positive bacteria (mutans streptococci, lactobacilli and actinomycetes). Periodontal diseases have been linked to anaerobic Gram-negative bacteria (Porphyromonas gingivalis, Actinobacillus, Prevotella and Fusobacterium). Given the incidence of oral disease, increased resistance by bacteria to antibiotics, adverse affects of some antibacterial agents currently used in dentistry and financial considerations in developing countries, there is a need for alternative prevention and treatment options that are safe, effective and economical. While several agents are commercially available, these chemicals can alter oral microbiota and have undesirable side-effects such as vomiting, diarrhea and tooth staining. Hence, the search for alternative products continues and natural phytochemicals isolated from plants used as traditional medicines are considered as good alternatives. In this review, plant extracts or phytochemicals that inhibit the growth of oral pathogens, reduce the development of biofilms and dental plaque, influence the adhesion of bacteria to surfaces and reduce the symptoms of oral diseases will be discussed further. Clinical studies that have investigated the safety and efficacy of such plant-derived medicines will also be described.

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Section: Antimicrobial Assaysmentioning

confidence: 99%

Section: Antibacterial Activity Of Crude or Total Plant Extractsmentioning

confidence: 99%

Traditional Medicinal Plant Extracts and Natural Products with Activity against Oral Bacteria: Potential Application in the Prevention and Treatment of Oral Diseases

Palombo

2011

Evidence-Based Complementary and Alternative Medicine

442

350

View full text Add to dashboard Cite

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“…Native to New Caledonia and Vanuatu in the Western Pacific, the plant is richly cultivated in Nigeria as an ornamental plant and as a natural remedy for malaria, fever, headaches, toothaches and tooth infections [14,15]. Amadi and colleagues (2017) reported the activity of aqueous and ethanol extracts of the leaf against Streptococcus mutans isolated from dental caries patients [16]. Onyegbule and colleagues (2014) reported the analgesic, anti-inflammatory and antimicrobial activity of the plant extracts [17]; and Johnson and colleagues (2020) reported its antimalarial activity [18].…”

Section: Introductionmentioning

confidence: 99%

Biochemical evaluation and molecular docking assessment of the anti-inflammatory potential of Phyllanthus nivosus leaf against ulcerative colitis

Johnson

Odoh

Nwonuma

et al. 2020

Heliyon

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Ulcerative colitis (UC) is an inflammation of the colon that can progress to colorectal cancer if left untreated. No medication completely cures UC and natural products are sources of alternative approaches. This study aimed to determine the anti-inflammatory potential of Phyllanthus nivosus leaf extract and fractions in a rat model of ulcerative colitis and to identify the active ingredients. UC was induced in rats by intra-rectal infusion of 1ml of 4% acetic acid (AA) in normal saline. AA exposed groups of rats were treated with 100 mg/kg bodyweight of methanol extract, hexane, ethyl-acetate and butanol fractions orally for four days. Another group received the standard drug -Dexamethasone and control rats were given distilled water only. Some biochemical changes were evaluated and the active ingredients were identified using Gas Chromatography-Mass Spectrometry (GC-MS) followed by molecular docking against interleukin-1-beta converting enzyme (Caspase-1), beta-2 adrenergic receptor (ADRB2), cyclooxygenase-2 (COX-2) and tumour necrosis factor-alpha (TNF-α). Exposure of rat colon to acetic acid significantly altered (p < 0.05) serum levels of tumour necrosis factor-alpha (TNF-α), interleukin -6 (IL-6), nitric oxide (NO), lipid peroxidation product (malondialdehyde or MDA), reduced glutathione (GSH); and activities of superoxide dismutase (SOD) and catalase (CAT). These alterations were however restored in the rats treated with P. nivosus leaf with the ethyl-acetate fraction displaying the highest ameliorative activity. GC-MS analysis of the ethyl acetate fraction revealed the presence of 40 compounds which when subjected to molecular docking demonstrated varying degrees of binding affinities for the protein targets. Ethyl iso-allocholate demonstrated the highest binding affinity for caspase-1, cholest-22-ene-21-ol, 3,5-dehydro-6-methoxy-, pivalate for ADRB2 and TNF-α; and alpha-cadinol for COX-2. The anti-inflammatory potential of Phyllanthus nivosus leaf as a natural remedy and as a source of new drugs against ulcerative colitis is validated.

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“…Ageratum conyzoides aerial part extracts had an effect on MSSA, MRSA, K. pneumoniae, and E. coli, but the MIC values were higher than T. erecta extracts. Amadi et al demonstrated that ethanol extract of A. conyzoides displayed the significant inhibitory zone on Streptococcus mutans [40]. Following the report of Akinyemi et al (2005), ethanol extract from A. conyzoides indicated MIC and MBC on MRSA of 43 μg/ml and 63.2 μg/ml, respectively [41].…”

Section: Evidence-based Complementary and Alternative Medicinementioning

confidence: 93%

DPPH-Scavenging and Antimicrobial Activities of Asteraceae Medicinal Plants on Uropathogenic Bacteria

Trinh

Le-Thi-Thanh

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Asteraceae species were widely applied in traditional medicines in Asian countries as sources of natural antioxidants and antimicrobial agents. This study aimed to evaluate DPPH-scavenging capacities and antimicrobial activities of nine Asteraceae species collected from Southern Vietnam. Antioxidant and antimicrobial activities were determined by standard protocols. Essential oils from Ageratum conyzoides, Helianthus annuus, and Artemisia vulgaris indicated significant inhibitory effects on Staphylococcus aureus and Candida spp. Crude extracts and fractions from Taraxacum officinale, Chrysanthemum morifolium, A. conyzoides, and Tagetes erecta showed inhibitory ability on at least one testing bacterial strains including S. aureus, Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa. In a study on clinical isolates, ethyl acetate fraction from A. conyzoides flower displayed the most potent effect on uropathogenic E. coli and K. pneumoniae with MIC at 1.25–10 mg/ml and 5–12.5 mg/ml, respectively. DPPH-scavenging assay indicated that T. erecta extract had the lowest IC50 (17.280 μg/ml) and is 2.4 times higher than vitamin C (7.321 μg/ml). This study revealed that A. conyzoides has good potential against uropathogenic E. coli and K. pneumoniae, and therefore could be applied for prophylactic treatment of urinary infection.

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Antimicrobial Screening of Breynia nivosus and Ageratum conyzoides Against Dental Caries Organisms

Cited by 16 publications

References 14 publications

Traditional Medicinal Plant Extracts and Natural Products with Activity against Oral Bacteria: Potential Application in the Prevention and Treatment of Oral Diseases

Traditional Medicinal Plant Extracts and Natural Products with Activity against Oral Bacteria: Potential Application in the Prevention and Treatment of Oral Diseases

Biochemical evaluation and molecular docking assessment of the anti-inflammatory potential of Phyllanthus nivosus leaf against ulcerative colitis

DPPH-Scavenging and Antimicrobial Activities of Asteraceae Medicinal Plants on Uropathogenic Bacteria

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