Antimicrobial screening and active compound isolation from marine bacterium NJ6-3-1 associated with the sponge Hymeniacidon perleve

Zheng, Li; Chen, Haimin; Han, Xiaotian; Lin, Wei; Yan, Xiaojun

doi:10.1007/s11274-004-3318-6

Cited by 81 publications

(64 citation statements)

References 32 publications

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“…The TLC bioautography was determined by agar-overlay method (Zheng et al, 2005). The TLC plate was placed in a sterile Petri plate and 20 ml of molten Mueller Hinton Agar was poured into plate (Hi media, Mumbai, India), aseptically.…”

Section: Tlc Based Bioautography (Agar-overlay Method)mentioning

confidence: 99%

Chemical composition, antioxidant and antisalmonella activity of Mangifera indica L. flower and seed kernel extracts

Kamble¹,

Somkuwar²,

Wankhade³

2016

Int Curr Pharm J

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The extracts obtained from flower and seed parts of Mangifera indica L. were investigated for antioxidant and antisalmonella activities. Disc diffusion assay and broth macrodilution method were used to determine the antisalmonella activity. However, DPPH assay used to determine antioxidant activities of petroleum ether, chloroform, acetone and ethanol extracts of flower and seed kernel of Mangifera indica L. The mineral content of different parts of Mangifera indica L. was determined using ICP-OES method. Seed kernel and flower were found to be the rich source of Fe with the concentration of 660.50 and 221.75 µg per gram of dry weight. The antioxidant activity of the extracts was determined by DPPH free radical scavenging method. The petroleum ether extract of flower and ethanol extract of flower exhibited the most significant antisalmonella activity with the lowest MIC value of 8 mg/ml. The highest antioxidant activity was recorded in petroleum ether seed kernel and chloroform flower extract with the percentage inhibition of 86.64 ± 2.49 and 79.80 ± 1.28, respectively. Among all the tested combinations chloroform flower and ethanol seed kernel extracts showed greater synergistic effect along with tetracycline against Salmonella typhi isolates. Four different compounds with dual property of antioxidant and antisalmonella were isolated from the petroleum ether seed kernel and acetone flower extracts using thin layer chromatography. GC-MS analysis of acetonic flower extract showed the presence of 1, 2-Benzenedicarboxylic acid, isodecyl octyl ester (Synonym: Phthalic acid). Compounds Oleic acid and eicosyl ester were found in petroleum ether seed kernel extract. The present study revealed that identified compounds are responsible for exhibiting antioxidant and antisalmonella activities in flower and seed kernel. These findings may justify the conventional use of Mangifera indica L. in the treatment of typhoid fever.Kamble et al., International Current Pharmaceutical Journal, September 2016, 5(10): 82-93http://www.icpjonline.com/documents/Vol5Issue10/02.pdf

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Section: Tlc Based Bioautography (Agar-overlay Method)mentioning

confidence: 99%

Chemical composition, antioxidant and antisalmonella activity of Mangifera indica L. flower and seed kernel extracts

Kamble¹,

Somkuwar²,

Wankhade³

2016

Int Curr Pharm J

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“…Marine sponge-associated microbes rely on sponges for nutrient acquisition and secondary metabolite production (Hentschel et al, 2002). The various secondary metabolites synthesized by microbial associates also possess excellent bioactivity in many studies (Pimentel-Elardo et al, 2010;Liu et al, 2005;Bringmann et al, 2003Bringmann et al, , 2005Zheng et al, 2005). Thus, sponge-associated micro-organisms represent an attractive source of marine natural products.…”

Section: Introductionmentioning

confidence: 99%

Evaluation on Anticancer Effect Against HL-60 Cells and Toxicity in vitro and in vivo of the Phenethyl Acetate Isolated from a Marine Bacterium Streptomyces griseus

Lee¹,

Zhang²,

Ko³

et al. 2015

Fisheries and aquatic sciences

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We previously identified Streptomyces griseus as an anti-cancer agent . In this study, we isolated compounds from S. griseus and evaluated their anticancer effect and toxicity in vitro and in vivo. Preparative centrifugal partition chromatography (CPC) was used to obtain three compounds, cyclo, cyclo( L -Phe-trans-4-hydroxy-L -Pro) and phenethyl acetate (PA). We chose PA, which had the highest anticancer activity, as a target compound for further experiments. PA induced the formation of apoptotic bodies, DNA fragmentation, DNA accumulation in G 0 /G 1 phase, and reactive oxygen species (ROS) formation. Furthermore, PA treatment increased Bax/Bcl-xL expression, activated caspase-3, and cleaved poly-ADP-ribose polymerase (PARP) in HL-60 cells. Simultaneous evaluation in vitro and in vivo, revealed that PA exhibited no toxicity in Vero cells and zebrafish embryos. We revealed, for the first time, that PA generates ROS, and that this ROS accumulation induced the Bcl signaling pathway.

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“…There is a continuous interest in the -carboline alkaloids representing an important class of synthetic and naturally occurring heterocycles with a wide spectrum of valuable pharmacological properties [1][2][3][4][5][6]. In the recent decades it was also demonstrated that -carboline alkaloids may have a pronounced potential as anti-cancer agents [7][8][9][10][11][12][13][14][15][16], which can act through different mechanisms including eg.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and structure of novel ferrocene-containing β-carbolines including polycondensed derivatives with the elements of planar-, central- and conformational chirality

Kovács

Jernei

Katona

et al. 2015

Journal of Organometallic Chemistry

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-Employing tryptamine or tryptophane methylester hydrochloride and (S p )-2-formylferrocene-1-carboxylate as precursors by means of Pictet-Spengler reactions and subsequent intramolecular acylation effected by cyanuricfluoride or carbonyldiimidazole (CDI), the first representatives of ferrocene-containing -carboline derivatives including polycyclic ferroceno/fused lactames, were prepared. In the course of CDI-mediated tandem cyclization of a tryptophane-derived carboxyferrocenyl-substituted -carboline, a ring enlargement simultaneously taking place with the loss of the  5 -C 5 H 5 Fe + fragment of the fused ferrocene moiety, effected by the coordinating imidazole released from the reagent, led to a 4H-cyclopenta [7,8]azonino [5,4-b]indole as a minor product. The constitution and relative configuration of the new compounds with the elements of planar-, central-and conformational chirality were established by NMR methods including HMQC, HMBC and NOESY measurements supported by DFT modeling studies.

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Antimicrobial screening and active compound isolation from marine bacterium NJ6-3-1 associated with the sponge Hymeniacidon perleve

Cited by 81 publications

References 32 publications

Chemical composition, antioxidant and antisalmonella activity of Mangifera indica L. flower and seed kernel extracts

Chemical composition, antioxidant and antisalmonella activity of Mangifera indica L. flower and seed kernel extracts

Evaluation on Anticancer Effect Against HL-60 Cells and Toxicity in vitro and in vivo of the Phenethyl Acetate Isolated from a Marine Bacterium Streptomyces griseus

Synthesis and structure of novel ferrocene-containing β-carbolines including polycondensed derivatives with the elements of planar-, central- and conformational chirality

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