Antimicrobial safety considerations in critically ill patients: part II: focused on anti-microbial toxicities

Shahbazi, Foroud; Shojaei, Lida; Farvadi, Fakhrossadat; Kadivarian, Sara

doi:10.1080/17512433.2022.2093716

Cited by 2 publications

(3 citation statements)

References 151 publications

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“…Minimizing the exposure of medically complex patients to unnecessary antimicrobials decreases the risk of adverse events, such as toxicity, secondary infections, and resistance, thus leading to improved patient outcomes. 4 , 5 We consider these interventions safe and effective, as we achieved our goal without adversely affecting all-cause mortality. Key interventions included forming a dedicated stewardship team, consensus building around the standardization of empiric antibiotic and culturing practices, and system-based changes within the EMR.…”

Section: Discussionmentioning

confidence: 99%

“…The unnecessary use of antibiotics can lead to end-organ damage, the development of secondary infections such as Clostridioides difficile, antimicrobial resistance, and other adverse events, resulting in a substantial number of annual healthcare visits and increased expenditures. [1][2][3][4] Up to 20% of hospitalized patients receiving antibiotics will experience an adverse drug event, many of which are preventable. 3,5 Additionally, the emergence and spread of antimicrobialresistant organisms continue to pose a significant challenge to global healthcare systems.…”

Section: Introductionmentioning

confidence: 99%

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Antimicrobial Stewardship and Improved Antibiotic Utilization in the Pediatric Cardiac Intensive Care Unit

Hillyer,

Jaggi,

Chanani

et al. 2024

Pediatric Quality &Amp; Safety

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Background: We developed a multidisciplinary antimicrobial stewardship team to optimize antimicrobial use within the Pediatric Cardiac Intensive Care Unit. A quality improvement initiative was conducted to decrease unnecessary broad-spectrum antibiotic use by 20%, with sustained change over 12 months. Methods: We conducted this quality improvement initiative within a quaternary care center. PDSA cycles focused on antibiotic overuse, provider education, and practice standardization. The primary outcome measure was days of therapy (DOT)/1000 patient days. Process measures included electronic medical record order-set use. Balancing measures focused on alternative antibiotic use, overall mortality, and sepsis-related mortality. Data were analyzed using statistical process control charts. Results: A significant and sustained decrease in DOT was observed for vancomycin and meropenem. Vancomycin use decreased from a baseline of 198 DOT to 137 DOT, a 31% reduction. Meropenem use decreased from 103 DOT to 34 DOT, a 67% reduction. These changes were sustained over 24 months. The collective use of gram-negative antibiotics, including meropenem, cefepime, and piperacillin-tazobactam, decreased from a baseline of 323 DOT to 239 DOT, a reduction of 26%. There was no reciprocal increase in cefepime or piperacillin-tazobactam use. Key interventions involved electronic medical record changes, including automatic stop times and empiric antibiotic standardization. All-cause mortality remained unchanged. Conclusions: The initiation of a dedicated antimicrobial stewardship initiative resulted in a sustained reduction in meropenem and vancomycin usage. Interventions did not lead to increased utilization of alternative broad-spectrum antimicrobials or increased mortality. Future interventions will target additional broad-spectrum antimicrobials.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antimicrobial Stewardship and Improved Antibiotic Utilization in the Pediatric Cardiac Intensive Care Unit

Hillyer,

Jaggi,

Chanani

et al. 2024

Pediatric Quality &Amp; Safety

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“…Antimicrobial therapy in the intensive care unit (ICU) is ubiquitous, with approximately 71% of patients receiving antibiotics [1]. Many antimicrobial drugs used can cause harm to critically ill patients, who often have multiple organ impairments [2][3][4][5][6][7]. Balancing potential damage from antimicrobial medications against appropriate source control and treatment of infection presents a challenge; in this narrative review, we aim to outline considerations and barriers to appropriate antimicrobial therapy for the sickest patients in hospitals.…”

Section: Introductionmentioning

confidence: 99%

Practical Lessons on Antimicrobial Therapy for Critically Ill Patients

Cusack,

Little,

Martin-Loeches

2024

Antibiotics

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Sepsis stands as a formidable global health challenge, with persistently elevated mortality rates in recent decades. Each year, sepsis not only contributes to heightened morbidity but also imposes substantial healthcare costs on survivors. This narrative review aims to highlight the targeted measures that can be instituted to alleviate the incidence and impact of sepsis in intensive care. Here we discuss measures to reduce nosocomial infections and the prevention of equipment and patient colonisation by resilient pathogens. The overarching global crisis of bacterial resistance to newly developed antimicrobial agents intensifies the imperative for antimicrobial stewardship and de-escalation. This urgency has been accentuated in recent years, notably during the COVID-19 pandemic, as high-dose steroids and opportunistic infections presented escalating challenges. Ongoing research into airway colonisation’s role in influencing disease outcomes among critically ill patients underscores the importance of tailoring treatments to disease endotypes within heterogeneous populations, which are important lessons for intensivists in training. Looking ahead, the significance of novel antimicrobial delivery systems and drug monitoring is poised to increase. This narrative review delves into the multifaceted barriers and facilitators inherent in effectively treating critically ill patients vulnerable to nosocomial infections. The future trajectory of intensive care medicine hinges on the meticulous implementation of vigilant stewardship programs, robust infection control measures, and the continued exploration of innovative and efficient technological solutions within this demanding healthcare landscape.

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Antimicrobial safety considerations in critically ill patients: part II: focused on anti-microbial toxicities

Cited by 2 publications

References 151 publications

Antimicrobial Stewardship and Improved Antibiotic Utilization in the Pediatric Cardiac Intensive Care Unit

Antimicrobial Stewardship and Improved Antibiotic Utilization in the Pediatric Cardiac Intensive Care Unit

Practical Lessons on Antimicrobial Therapy for Critically Ill Patients

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