Antimicrobial resistant Escherichia coli in Scottish wild deer: Prevalence and risk factors

Elsby, Derek T.; Zadoks, Ruth N.; Boyd, Kenneth; Silva, Nuno; Chase-Topping, Margo; Mitchel, Mairi C.; Currie, Colin; Taggart, Mark A.

doi:10.1016/j.envpol.2022.120129

Cited by 3 publications

(2 citation statements)

References 51 publications

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“…The deer resistance data obtained recently in Scotland revealed that AMR E. coli can appear in deer populations not directly exposed to the selective pressure exerted by antibiotherapy. Exactly like in our case, researchers concluded that resistance to critically important antimicrobials was low in the studied deer population, evoking no immediate peril regarding human health [ 44 ].…”

Section: Discussionsupporting

confidence: 54%

The Behavior of Some Bacterial Strains Isolated from Fallow Deer Compared to Antimicrobial Substances in Western Romania

Tîrziu¹,

Bulucea²,

Imre³

et al. 2023

Antibiotics

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(1) Background: The resistance levels of Escherichia coli, Salmonella spp., Pseudomonas spp., Staphylococcus spp., etc., isolated from the nasal cavity and the rectum of Dama dama deer from three hunting grounds in Western Romania were assessed. (2) Methods: The analysis was completed using the diffusimetric method, compliant with CLSI reference standards, and with Vitek-2 (BioMérieux, France), on 240 samples. (3) Results: The results were statistically analyzed (by one-way ANOVA) revealing that in four of the ten E. coli strains isolated from animals, 87.5% (p < 0.001) resistance was found. E. coli strains were resistant to cephalexin (100%); seven strains were resistant to cephalothin and ampicillin; six were resistant to cefquinome and cefoperazone; five were resistant to amoxicillin/clavulanic acid; and four were resistant to ceftiofur. However, E. coli was sensitive to amikacin (100%). The most efficient structures were beta-lactams, amikacin, and imipenem, to which all 47 strains studied (100%) were sensitive, followed by nitrofurantoin, to which 45 strains (95.7%) were sensitive, neomycin, to which 44 strains (93.6%) were sensitive, ceftiofur, to which 43 strains (91.5%) were sensitive, and trimethoprim/sulfamethoxazole and marbofloxacin, to which 42 strains (89.4%) were sensitive. (4) Conclusions: In wild animal populations, where a human presence is frequently reported, including a constant presence of domestic animals, despite the perceived low risk of emerging resistance to antimicrobials, resistance is likely to develop frequently.

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Section: Discussionsupporting

confidence: 54%

The Behavior of Some Bacterial Strains Isolated from Fallow Deer Compared to Antimicrobial Substances in Western Romania

Tîrziu¹,

Bulucea²,

Imre³

et al. 2023

Antibiotics

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“…16,37 Studies in Scotland, Japan, and Germany have identified resistant E coli in deer, with resistance to tetracycline, cefpodoxime, and other clinically important antimicrobials. 16,33,38 A range of AMR and ARB have been found in wild cervids, including red deer, roe deer, moose, and reindeer. These include resistant E coli, E faecalis, E faecium, and C jejuni.…”

Section: Wild Ungulates and Other Ruminantsmentioning

confidence: 99%

Current understanding and knowledge gaps regarding wildlife as reservoirs of antimicrobial resistance

Vezeau,

Kahn

2024

ajvr

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Antimicrobial resistance (AMR) is a serious health issue shared across all One Health domains. Wildlife species represent a key intersection of the animal and environmental domains. They are a relevant but understudied reservoir and route of spread for AMR throughout the environment. Most wildlife AMR research thus far has focused on avian species, terrestrial mammals, and a selection of aquatic and marine species. Pathogens often identified in terrestrial wildlife include enteric zoonotic organisms such as Eschericia coli and Salmonella spp, in addition to nonenterics such as Staphylococci. Resistances have been commonly identified to antimicrobials important in veterinary and human medicine, including β-lactams, tetracyclines, aminoglycosides, and macrolides. Our emerging understanding of the dynamics of AMR distribution across life on Earth provides further opportunities for us to assess the risk it poses to veterinary and human health. Future work will require prioritizing which wildlife most exacerbates and indicates AMR in domestic animals. However, decreasing prices and increasing ease for metagenomic sequencing allows for synergies with expanding wildlife viral disease surveillance. Improved understanding of how wildlife impacts veterinary and human healthcare may increase opportunities for related research funding and global equity in such research. The companion Currents in One Health article by Vezeau and Kahn, JAVMA, June 2024, addresses in further detail the routes of spread of AMR across different animal populations and actions that can be taken to mitigate AMR with special consideration for wildlife sources.

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Exploiting genomics for antimicrobial resistance surveillance at One Health interfaces

Muloi,

Jauneikaite,

Anjum

et al. 2023

The Lancet Microbe

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Antimicrobial resistant Escherichia coli in Scottish wild deer: Prevalence and risk factors

Cited by 3 publications

References 51 publications

The Behavior of Some Bacterial Strains Isolated from Fallow Deer Compared to Antimicrobial Substances in Western Romania

The Behavior of Some Bacterial Strains Isolated from Fallow Deer Compared to Antimicrobial Substances in Western Romania

Current understanding and knowledge gaps regarding wildlife as reservoirs of antimicrobial resistance

Exploiting genomics for antimicrobial resistance surveillance at One Health interfaces

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