Antimicrobial Resistance Traits and Resistance Mechanisms in Bacterial Pathogens

Paul, Deepjyoti; Verma, Jyoti; Banerjee, Anindita; Konar, Dipasri; Das, Bhabatosh

doi:10.1007/978-981-16-3120-7_1

Cited by 4 publications

(2 citation statements)

References 93 publications

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“…When a bacterial population is no longer susceptible to an antimicrobial agent then the bacteria is termed as resistant to that antimicrobial. Bacterial species can either have intrinsic ability to resist antimicrobial agents or it can acquire resistance genes from other bacterial species (Paul et al, 2022). Intrinsic resistance is because of the inherent functional or structural characteristics of bacteria that allow tolerance to a particular antimicrobial agent (Cox and Wright, 2013).…”

Section: Antimicrobial Resistance and Its Mechanismsmentioning

confidence: 99%

Antibiotic Potentiators Against Multidrug-Resistant Bacteria: Discovery, Development, and Clinical Relevance

et al. 2022

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Antimicrobial resistance in clinically important microbes has emerged as an unmet challenge in global health. Extensively drug-resistant bacterial pathogens have cropped up lately defying the action of even the last resort of antibiotics. This has led to a huge burden in the health sectors and increased morbidity and mortality rate across the world. The dwindling antibiotic discovery pipeline and rampant usage of antibiotics has set the alarming bells necessitating immediate actions to combat this looming threat. Various alternatives to discovery of new antibiotics are gaining attention such as reversing the antibiotic resistance and hence reviving the arsenal of antibiotics in hand. Antibiotic resistance reversal is mainly targeted against the antibiotic resistance mechanisms, which potentiates the effective action of the antibiotic. Such compounds are referred to as resistance breakers or antibiotic adjuvants/potentiators that work in conjunction with antibiotics. Many studies have been conducted for the identification of compounds, which decrease the permeability barrier, expression of efflux pumps and the resistance encoding enzymes. Compounds targeting the stability, inheritance and dissemination of the mobile genetic elements linked with the resistance genes are also potential candidates to curb antibiotic resistance. In pursuit of such compounds various natural sources and synthetic compounds have been harnessed. The activities of a considerable number of compounds seem promising and are currently at various phases of clinical trials. This review recapitulates all the studies pertaining to the use of antibiotic potentiators for the reversal of antibiotic resistance and what the future beholds for their usage in clinical settings.

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Section: Antimicrobial Resistance and Its Mechanismsmentioning

confidence: 99%

Antibiotic Potentiators Against Multidrug-Resistant Bacteria: Discovery, Development, and Clinical Relevance

et al. 2022

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“…The ESKAPE pathogens ( Enterococcus faecium , Staphylococcus aureus , Klebsiella pneumoniae , Acinetobacter baumannii , Pseudomonas aeruginosa , and Enterobacter species) were given “priority status” within this lengthy list [ 6 ]. ESKAPE pathogens have established resistance mechanisms against antibiotics that are the last line of defense, such as glycopeptides, carbapenems, and clinically unfavorable polymyxins, through genetic mutation and the acquisition of mobile genetic elements (MGEs) [ 7 ]. Furthermore, ESKAPE pathogens were also found to express high resistance patterns to lipopeptides, tetracyclines, macrolides, fluoroquinolones, oxazolidinones, and β-lactams antibiotics [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Synergistic Antibacterial Proficiency of Green Bioformulated Zinc Oxide Nanoparticles with Potential Fosfomycin Synergism against Nosocomial Bacterial Pathogens

et al. 2023

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The drug resistance of bacterial pathogens causes considerable morbidity and death globally, hence there is a crucial necessity for the development of effective antibacterial medicines to address the antibacterial resistance issue. The bioprepared zinc oxide nanoparticles (ZnO-NPs) were prepared utilizing the flower extract of Hibiscus sabdariffa and then characterized using different physicochemical techniques. The antibacterial effectiveness of the bioprepared ZnO-NPs and their synergism with fosfomycin were evaluated using disk diffusion assay against the concerned pathogens. Transmission electron microscopy (TEM) investigation of the bioprepared ZnO-NPs showed that their average particle size was 18.93 ± 2.65 nm. Escherichia coli expressed the highest sensitivity to the bioinspired ZnO-NPs with a suppressive zone of 22.54 ± 1.26 nm at a concentration of 50 µg/disk, whereas the maximum synergistic effect of the bioinspired ZnO-NPs with fosfomycin was noticed against Klebsiella pneumoniae strain with synergism ratio of 100.29%. In conclusion, the bioinspired ZnO-NPs demonstrated significant antibacterial and synergistic efficacy with fosfomycin against the concerned nosocomial bacterial pathogens, highlighting the potential of using the ZnO NPs-fosfomycin combination for effective control of nosocomial infections in intensive care units (ICUs) and health care settings. Furthermore, the biogenic ZnO-NPs’ potential antibacterial action against food pathogens such as Salmonella typhimurium and E. coli indicates their potential usage in food packaging applications.

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Antibiotic Resistance Profile and Detection in ESKAPE Pathogens

Agrawal,

Patel

2024

ESKAPE Pathogens

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Antimicrobial Resistance Traits and Resistance Mechanisms in Bacterial Pathogens

Cited by 4 publications

References 93 publications

Antibiotic Potentiators Against Multidrug-Resistant Bacteria: Discovery, Development, and Clinical Relevance

Antibiotic Potentiators Against Multidrug-Resistant Bacteria: Discovery, Development, and Clinical Relevance

Synergistic Antibacterial Proficiency of Green Bioformulated Zinc Oxide Nanoparticles with Potential Fosfomycin Synergism against Nosocomial Bacterial Pathogens

Antibiotic Resistance Profile and Detection in ESKAPE Pathogens

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