Antimicrobial Resistance: Scoping Review Article.

Abstract

Antimicrobial resistance is natural phenomenon that occurs when microorganisms are exposed to antibiotic drugs. Under the selective pressure of antibiotics, susceptible bacteria are killed or inhibited, while bacteria that are naturally (or intrinsically) resistant or that have acquired antibiotic-resistant traits have a greater chance to survive and multiply. Many alarming facts regarding antimicrobial resistance have accumulated, particularly over the last few years some of which includes an increase in global resistance rates in many bacterial species responsible for both community- and healthcare-related infections, emergence and dissemination of new mechanisms of resistance, rapid increase in multi-resistance, propensity to use last line therapy to treat nosocomial and community acquired infections, reuse of old drugs with poor efficacy profile and uncertain pharmacokinetics/pharmacodynamics characteristics due to lack of alternative drugs, high morbidity and mortality attributable to multi-resistant bacteria in critically ill patients and serious financial consequences of bacterial resistance. Various steps that health care practitioners and facilities can pursue to reduce antibiotic resistance such as adopting an antibiotic stewardship program, improving diagnosis, tracking and prescribing practices, optimizing therapeutic regimens and preventing infection transmission.

Determination of antimicrobial resistance patterns of Escherichia coli isolates from farm workers in broiler poultry production and assessment of antibiotic resistance awareness levels among poultry farmers in Lusaka, Zambia

“…Transmission of resistant E. coli strains from poultry to humans is of great concern because the acquired resistance can occur in pathogenic bacteria and the endogenous bacterial flora of exposed individuals or populations ( 19 , 20 ). AMR poses challenges in Diering and Mitchell ( 16 ) managing and treating infections in both food animals and humans ( 21 , 22 ) due to the increase in number of infections, prolonged duration of infection, limited choice of empirical treatment antibiotics, and complications resulting from failed treatment; consequently result in increased cost to society.…”