Antimicrobial Resistance Pattern of Bacterial Isolates from Urinary Tract Infections at a Tertiary Care Centre

Bhatt, Puneet; Jagani, Rajat; Ranjan, Priya; Namaji, Mohd Ashraf Ali; Rathi, KR

doi:10.20546/ijcmas.2017.601.022

Cited by 2 publications

(2 citation statements)

References 6 publications

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“…The results in this study showed that the isolated uropathogens were mostly resistant to 3 rd -generation cephalosporins including CAZ, CRO and FEP (which considered extended β-lactam agents) than to non-βlactam agents such as CIP and CN. This result is in agreement with that of Bhatt et al (2017) who reported that β-lactams, and fluoroquinolones antibiotics have limited value for the treatment of UTI infected by Gram negative bacteria and there was extreme resistance towards CAZ, FEP and CRO higher than CN.…”

Section: Results and Discusionsupporting

confidence: 93%

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Phenotypic detection of extended spectrum -lactamase and Metallo -lactamase production by Gram negative uropathogens after exposure to gamma radiation

El-Zawahry¹,

Mousa²,

Araby³

et al. 2020

Afr. J. Microbiol. Res.

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Eighty-five uropathogen isolates were collected and differentiated on the basis of their Gram stain reaction. Among the collected isolates, 25 (29.4%) were Gram positive cocci and 60 (70.6%) were Gram negative bacilli. Antibiotic susceptibility profile towards 15 different antibiotics concluded that impenime (IMP), amikacin (AK) and Pipperacillin/tazobactam (TZP) were the most effective against Gram negative; while linezolid (LZD), and vancomycin (VA) were the most potent against Gram positive. The highly drug resistant isolates were identified as Pseudomonas aeruginosa and Klebsiella pneumoniae using 16srRNA; the two strains were subjected to different doses of gamma-radiation and the sub lethal dose of both strains was 5.0 kGy. The D 10 values were recorded (1.2 and 1.1 kGy) for P. aeruginosa and K. pneumoniae), respectively. In addition, gamma-irradiation technique decreases the resistance of K. pneumoniae towards IMP and the resistance of P. aeruginosa towards more than one antibiotic (TZP, AZM and CIP). The results also, revealed that both of the tested strains had the ability to produce Extended Spectrum β-lactamase (ESBL) before and after gamma-radiation but only P. aeruginosa had the ability to produce Metallo β-lactamase (MBL), that is, ESBL and MBL co-production was detected in P. aeruginosa. So, these findings must be supported by other studies on the level of genes to prove the possibility for using gamma-irradiation technique to overcome microbial drug resistance problem.

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Section: Results and Discusionsupporting

confidence: 93%

“…Regarding the tested Gram positive isolates, the data revealed that VA and LZD were the strongest agents and this agreed with the results of Bhatt et al (2017) who reported that VA and LZD were found to be the most effective against Gram-positive isolates.…”

Section: Results and Discusionsupporting

confidence: 89%

Phenotypic detection of extended spectrum -lactamase and Metallo -lactamase production by Gram negative uropathogens after exposure to gamma radiation

El-Zawahry¹,

Mousa²,

Araby³

et al. 2020

Afr. J. Microbiol. Res.

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Multidrug Resistant Bacteria in Urinary Tract Infection: A Constant Threat to a Tertiary Care Health Set-up in North India

Kaira¹,

Khan²

2014

Journal of Medical Academics

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Introduction: Urinary tract infections (UTIs) is one of the most common bacterial infections. Irrelevant use of antibiotics has resulted in the emergence of resistant strains. Aims and objective:To identify and look for the antimicrobial resistance pattern of various isolates in a tertiary care teaching hospital.Methods: A retrospective study was conducted in a tertiary level hospital for 4 years (March 2014to March 2018. A total of 41020 urine samples received in the laboratory and 6114 of them diagnosed to be culture positive UTI were processed for Antibiotic sensitivity by the standard microbiological procedure.Results: Out of 6114 culture, positive samples 2829 (46.27%) had significant bacteriuria. Females more affected (52.27%) than males (48.43%). Amongst fermenters (GNF), E.coli (52.7%) was most common followed by Klebsiella spp. (23.65%). Amongst the Gram-positive organisms Enterococcus spp. (3.67%) was more common followed by Staphylococcus saprophyticus (1.44%). While Pseudomonas spp. followed by Burkholderia sp were the common non-fermenters (GNNF). In GNF, imipenem, meropenem and amikacin were most effective drugs whereas, in GNNF, imipenem, meropenem and piperacillin-tazobactam were more effective. Linezolid and vancomycin were the most sensitive antibiotics in Gram-positive isolates. Conclusion:There is increasing resistance to, and nitrofurantoin noted in our study that is frequently considered drugs of choice for empiric therapy. It is important to determine trends in antimicrobials susceptibilities, to formulate local antibiotics policy that will guide the clinicians regarding the empirical choice for UTI to prevent misuse or overuse of antibiotics.Clinical significance: Because of the emerging resistance to the available group of antimicrobials, regular monitoring of the resistance pattern is essential for the clinicians to choose for the best empiric therapy.

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Antimicrobial Resistance Pattern of Bacterial Isolates from Urinary Tract Infections at a Tertiary Care Centre

Cited by 2 publications

References 6 publications

Phenotypic detection of extended spectrum -lactamase and Metallo -lactamase production by Gram negative uropathogens after exposure to gamma radiation

Phenotypic detection of extended spectrum -lactamase and Metallo -lactamase production by Gram negative uropathogens after exposure to gamma radiation

Multidrug Resistant Bacteria in Urinary Tract Infection: A Constant Threat to a Tertiary Care Health Set-up in North India

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