Antimicrobial Resistance of Thermotolerant <i>Campylobacter</i> Species Isolated from Humans, Food-Producing Animals, and Products of Animal Origin: A Worldwide Meta-Analysis

Signorini, Marcelo; Rossler, Eugenia; David, D. C. Díaz; Olivero, Carolina Raquel; Romero-Scharpen, Analía; Soto, L.P.; Astesana, Diego M.; Berisvil, Ayelén Patricia; Zimmermann, Jorge Alberto; Fusari, M.L.; Frizzo, L.S.; Zbrun, María Virginia

doi:10.1089/mdr.2017.0310

Cited by 26 publications

(26 citation statements)

References 33 publications

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“…These findings were in agreement with that previously reviewed in many studies (Saleha, 2002;Sáenz et al, 2000;Aarestrup and Engberg, 2001;Taremi et al, 2006). In contrary, C. coli showed a higher prevalence of antimicrobial resistance than C. jejuni by Signorini et al (2018) In this study, Campylobacter isolates were more sensitive to ciprofloxacin which is in agreement with McDermott et al (2002) and Moore et al (2005) who stated that ciprofloxacin was the drug of choice for empirical therapy of bacterial food borne diarrhea, including that caused by Campylobacter. In addition, Kassa et al (2007) found that C. jejuni, C. coli and C. lari isolated from food animals were sensitive to chloramphenicol and ciprofloxacin.…”

Section: Resultssupporting

confidence: 93%

Prevalence, cytotoxicity and antibiotic susceptibility of Campylobacter species recovered from retail chicken meat in Mansoura, Egypt

Hafez¹,

Younis²,

El-Shorbagy³

et al. 2018

Afr. J. Microbiol. Res.

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This study was performed to determine the prevalence of Campylobacter species in retail chicken meat and chicken by-product, determine their in vitro cytotoxicity, as well as, examine their susceptibility to different antimicrobials. A total of 300 raw chicken meat samples were collected from different retail chicken meat outlets located at Mansoura city, Egypt classified into 120 thighs, 120 breasts, and 60 livers. All samples were subjected to conventional culture techniques and confirmed as Campylobacter jejuni by real time polymerase chain reaction (PCR). Antimicrobial susceptibility of Campylobacter species was determined using disc diffusion method to determine their susceptibility to 12 different antimicrobial agents. In addition, C. jejuni isolates were examined for their cytotoxicity against Vero cells. The overall prevalence of Campylobacter spp. was 10.3% (31/300) classified into 20 (18.2%) C. jejuni and 11 (10.7%) Campylobacter coli. Among C. jejuni isolates (n=20), 15 strains belonged to biotype I and 5 isolates belonged to biotype II. The isolation rate from chicken thighs, breasts and livers was 12.5, 10 and 6.6%, respectively. A total of 15 (75%) C. jejuni strains revealed cytopathic effect (CPE) against Vero cells. Campylobacter spp. displayed a high antimicrobial resistance against penicillin G, gentamicin, trimethoprim-sulfamethoxazole, cephalothin, erythromycin, and chloramphenicol. On the other hand, Campylobacter spp. displayed high sensitivity to ciprofloxacin and nalidixic acid. Multidrug resistance was observed in 85 and 81.82% of C. jejuni and C. coli isolates, respectively. High frequency of cytotoxicity and multidrug resistance in Campylobacter spp. from chicken meat indicates an important epidemiological role of Campylobacter spp. in human infections which necessitate proper hygienic measures on poultry farms and control measures during carcass slaughtering and processing.

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Section: Resultssupporting

confidence: 93%

Prevalence, cytotoxicity and antibiotic susceptibility of Campylobacter species recovered from retail chicken meat in Mansoura, Egypt

Hafez¹,

Younis²,

El-Shorbagy³

et al. 2018

Afr. J. Microbiol. Res.

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“…e antimicrobials to which resistance was high included AMP, TET, ERY, and TET. e findings concur with the reports from other studies in both LMICs and high-income countries showing an increment in the number of Campylobacter strains resistant to most of the antimicrobials used in treating human campylobacteriosis [118][119][120]. e increase in resistance to most antimicrobial agents and emergence of MDR isolates could be associated with extensive use of antimicrobials not only as therapeutic agents for human infections [20] but also for prophylaxis and growth promotion in animal husbandry [68].…”

supporting

confidence: 89%

“…ese may cause differences within and between countries and certainly limit comparability with data reported in other parts of the world. e resistance to TET was comparable with the findings reported from Poland [121] and the USA [122] and the pooled estimate prevalence worldwide (94.3%) [120]. is resistance International Journal of Microbiology may be due to wide use of tetracycline in both human and veterinary medicine [20].…”

supporting

confidence: 83%

Prevalence, Risk Factors, and Antimicrobial Resistance Profiles of Thermophilic Campylobacter Species in Humans and Animals in Sub-Saharan Africa: A Systematic Review

Gahamanyi

Mboera

Matee

et al. 2020

International Journal of Microbiology

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Thermophilic Campylobacter species are clinically important aetiologies of gastroenteritis in humans throughout the world. The colonization of different animal reservoirs by Campylobacter poses an important risk for humans through shedding of the pathogen in livestock waste and contamination of water sources, environment, and food. A review of published articles was conducted to obtain information on the prevalence and antimicrobial resistance (AMR) profiles of thermophilic Campylobacter species in humans and animals in sub-Saharan Africa (SSA). Electronic databases, namely, PubMed, Google Scholar, Research4life-HINARI Health, and Researchgate.net, were searched using the following search terms “thermophilic Campylobacter,” “Campylobacter jejuni,” “Campylobacter coli,” “diarrhea/diarrhoea,” “antimicrobial resistance,” “antibiotic resistance,” “humans,” “animals,” “Sub-Saharan Africa,” and “a specific country name.” Initially, a total of 614 articles were identified, and the lists of references were screened in which 22 more articles were identified. After screening, 33 articles on humans and 34 on animals and animal products were included in this review. In humans, Nigeria reported the highest prevalence (62.7%), followed by Malawi (21%) and South Africa (20.3%). For Campylobacter infections in under-five children, Kenya reported 16.4%, followed by Rwanda (15.5%) and Ethiopia (14.5%). The country-level mean prevalence in all ages and under-five children was 18.6% and 9.4%, respectively. The prevalence ranged from 1.7%–62.7% in humans and 1.2%–80% in animals. The most reported species were C. jejuni and C. coli. The AMR to commonly used antimicrobials ranged from 0–100% in both humans and animals. Poultry consumption and drinking surface water were the main risk factors for campylobacteriosis. The present review provides evidence of thermophilic Campylobacter occurrence in humans and animals and high levels of AMR in SSA, emphasizing the need for strengthening both national and regional multisectoral antimicrobial resistance standard surveillance protocols to curb both the campylobacteriosis burden and increase of antimicrobial resistance in the region.

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“…Interestingly, in recent years there has been an increase in the use of antimicrobials in animal breeding systems. The type of antimicrobial used, as well as the frequency and dose applied in animal feed may explain, at least partially, the prevalence of Campylobacter in food‐producing animals and the emergence of antimicrobial resistance in TC (Lévesque, Frost, & Michaud, ; Luber, Wagner, Hahn, & Bartelt, ; Signorini et al, ; Silbergeld, Graham, & Price, ; Wieczorek & Osek, ; Zbrun et al, ). The relatively stable prevalence of TC is accompanied by a gradual increase in the proportion of isolates resistant to antimicrobials, a phenomenon that became more evident in the last decade (Wieczorek & Osek, ).…”

Section: Discussionmentioning

confidence: 99%

Meta‐analysis of the prevalence of thermotolerant Campylobacter in food‐producing animals worldwide

Rossler

Signorini

Romero-Scharpen

et al. 2019

Zoonoses and Public Health

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The objective of this meta-analysis was to summarize available information on the prevalence of thermotolerant Campylobacter (TC) in different food-producing animals worldwide. Databases (i.e., PubMed, ScienceDirect, Scopus) were searched from 1980 to 2017 unrestricted by language. The inclusion criteria were as follows: prevalence or incidence studies, published in peer-reviewed journals, and they must have reported the total number of animal samples studied and the number of samples that were positive for the presence of TC. When the identification of Campylobacter species was available, this information was included in the analysis.Multilevel random-effect meta-analysis models were fitted to estimate mean occurrence rate of TC and to compare them among different factors potentially associated with the outcome. The mean occurrence rate of TC in food-producing animals was 0.424 (95% CI: 0.394-0.455), and the mean occurrence rate of Campylobacter jejuni and Campylobacter coli were 0.214 and 0.133, respectively. Pigs and poultry showed the highest prevalence of TC; however, there were differences in the prevalence of each Campylobacter species. Campylobacter jejuni was observed in broilers (0.322; 95% CI: 0.273-0.377) and hens (0.395; 95% CI: 0.265-0.542), while C. coli was restricted essentially in pigs (0.553; 95% CI: 0.541-0.650). The prevalence of C. jejuni in intensively bred cattle was higher (0.302; 95% CI: 0.227-0.389) than the prevalence in extensively bred cattle (0.172; 95% CI: 0.119-0.242) while the prevalence of C. coli was similar (0.051; 95% CI: 0.028-0.091 vs. 0.050; 95% CI: 0.027-0.091) in both production systems. Agar with or without blood used for the isolation of TC did not affect the prevalence observed. The method of species identification did not seem to generate differences in the prevalence of Campylobacter species. The prevalence of Campylobacter in primary food production has a strong impact on the entire agri-food chain. National authorities must monitor the situation with the aim to establish the appropriate risk management measures. K E Y W O R D Sfood-producing animals, meta-analysis, prevalence, thermotolerant Campylobacter

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Antimicrobial Resistance of Thermotolerant Campylobacter Species Isolated from Humans, Food-Producing Animals, and Products of Animal Origin: A Worldwide Meta-Analysis

Cited by 26 publications

References 33 publications

Prevalence, cytotoxicity and antibiotic susceptibility of Campylobacter species recovered from retail chicken meat in Mansoura, Egypt

Prevalence, cytotoxicity and antibiotic susceptibility of Campylobacter species recovered from retail chicken meat in Mansoura, Egypt

Prevalence, Risk Factors, and Antimicrobial Resistance Profiles of Thermophilic Campylobacter Species in Humans and Animals in Sub-Saharan Africa: A Systematic Review

Meta‐analysis of the prevalence of thermotolerant Campylobacter in food‐producing animals worldwide

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