Antimicrobial resistance of pathogens causing community-acquired urinary tract infections in Russia: results of the multicenter study “DARMIS-2018”

Palagin, Ivan; Сухорукова, М В; Дехнич, А В; Edelstein, Mikhail V.; Перепанова, Т С; Kozlov, Roman

doi:10.36488/cmac.2019.2.134-146

Cited by 31 publications

(14 citation statements)

References 7 publications

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“…Unsurprisingly, however, the main limitation identified by this approach was the lack of consistency and comprehensiveness and high fragmentation of data coming from various research studies. On the other hand, prospective multicenter surveillance studies on resistance of community and nosocomial bacterial pathogens were conducted by the Institute of Antimicrobial Chemotherapy (IAC) and the Interregional Association for Clinical Microbiology and Antimicrobial Chemotherapy (IACMAC) in Russia since the 1990s until the present, which allowed for building a unique collection of clinical isolates and for accumulating large amount of AMR data from centralized testing (Kozlov et al, 2002;Stratchounski et al, 2005;Stratchounski and Rafalski, 2006;Edelstein et al, 2013;Palagin et al, 2019;Sukhorukova et al, 2019). Here, we report the development of the newergeneration web platform, AMRmap (see text footnote 1), for in-depth analysis and visualization of AMR data collected from prospective microbiological surveillance program in Russia whose functionality extends beyond the limits of the existing online resources.…”

Section: Introductionmentioning

confidence: 99%

AMRmap: An Interactive Web Platform for Analysis of Antimicrobial Resistance Surveillance Data in Russia

et al. 2021

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Surveillance of antimicrobial resistance (AMR) is crucial for identifying trends in resistance and developing strategies for prevention and treatment of infections. Globally, AMR surveillance systems differ in terms of organizational principles, comprehensiveness, accessibility, and usability of data presentation. Until recently, the data on AMR in Russia were scarcely available, especially to international community, despite the fact that the large prospective multicenter surveillance in Russia was conducted and data were accumulated for over 20 years. We describe the source of data, structure, and functionality of a new-generation web platform, called AMRmap (https://amrmap.net/), for analysis of AMR surveillance data in Russia. The developed platform currently comprises susceptibility data of >40,000 clinical isolates, and the data on abundance of key resistance determinants, including acquired carbapenemases in gram-negatives, are updated annually with information on >5,000 new isolates. The AMRmap allows smart data filtration by multiple parameters and provides interactive data analysis and visualization tools: MIC and S/I/R distribution plots, time-trends and regression plots, associated resistance plots, prevalence maps, statistical significance graphs, and tables.

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Section: Introductionmentioning

confidence: 99%

AMRmap: An Interactive Web Platform for Analysis of Antimicrobial Resistance Surveillance Data in Russia

et al. 2021

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“…Результаты приведенных европейских и амери канских исследований соотносятся с данными по следнего крупного многоцентрового исследования «ДАРМИС2018» (Рисунок 2), в котором чувствитель ность изолятов E. coli, выделенных у взрослых с вне больничными ИМП в России (n = 523), составила 97,7% при частоте продукции БЛРС, по данным фенотипичес ких методов, равной 27,0% [12].…”

Section: резистентность уропатогенов к фосфомицина трометамолу и другим ампunclassified

War and Peace: the difficult treatment of urinary tract infections and fosfomycin trometamol

Palagin

Перепанова²,

Pushkar

et al. 2021

CMAC

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The title of this review “War and peace” is not accidental and the analogies with a well-known literary masterpiece have absolutely justified ground. As in the case of Lev Tolstoy’s novel this title has a profound philosophical meaning, although at first glance it may seem quite obvious. The word «war» may well correspond to those hostile changes of microorganisms leading to the current problem of antimicrobial resistance recognized worldwide. This is the “war” we have to wage against the antibiotic-resistant bacteria today. And the «peace» in this context is considered as the world, the entire universe, all people, the whole society and its reaction to what is happening. On the other hand, the word «peace» means something opposite in meaning to the word «war». Thus, the essence of the title bears a sharp contrast between military actions and peacetime, between something that carries a threat to life and peace, or illness and recovery. Preserving original novel’s structure the authors of this review consistently consider justification of fosfomycin trometamol as a first-line drug in the treatment of acute uncomplicated cystitis in women taking into account the latest research, publications and global trends.

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“…P. mirabilis often insulates wounds, forming biofilms, which protects the pathogen from the effects of antimicrobial agents and makes treatment difficult (Leblebicioglu andEsen 2003, Schaffer et al 2016). P. mirabilis is known as an etiological agent of the onset of nosocomial pneumonia (Pаlаgin et al 2012). There is an increased interest towards the role of Proteus in the etiology of rheumatoid arthritis (RA) and towards the development of chemotherapeutic drugs which are active against protei that can reduce the risk of and/or worsening RA development (Ushakova et al 2001, Disaanayake et al 2014.…”

Section: Introductionmentioning

confidence: 99%

Investigation of the activity of new derivatives of 1,3-diazinone-4 and their acyclic precursors with respect to bacteria of the genus Proteus

Лужнова¹,

Voronkov²,

Габитова³

et al. 2018

RRP

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Introduction: The present paper provides a study of the activity of the new 1,3-diazinon-4 derivatives and their acyclic precursors under the laboratory cipher PYaTd1, PYaTs2, PYaTs3 and PYaTs4 against microorganisms of the genus Proteus, which is of high importance at the moment as the growing resistance of the Proteus to previously highly active antibiotics dictates the need to search for effective antimicrobial agents that meet modern safety requirements. Materials and Methods: The study of the activity of the compounds was carried out on collection and freshly isolated strains from patients with different pathologies. The strains were identified using the BIOMIC V3 apparatus (Giles Scientific, USA) to verify genus and species identity. The strains used in the study were previously examined for susceptibility to antibacterial drugs by the Disc Method to assess the presence or absence of resistance. The activity of the new compounds was studied by the serial dilution method. Results: The results of the study showed that the compounds PYaTd1, PYaTs2, PYaTs3 and PYaTs4 show a different activity against bacteria of the genus Proteus. The substance PYaTs2 is ineffective. With respect to strains P.mirabilis and P.rettgeri, the minimum inhibitory concentration of the compounds PYaTs3, PYaTs4 and PYaTd1 ranges from 4 μg/ml to 16 μg/ml. Conclusion: Thus, by the average aggregate indices, regardless of the species and strain of bacteria, the most effective compound is PYaTd1, the MIC50 of which is within 10 μg/ml, which proves it to be promising and makes further development worthwhile.

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Antimicrobial resistance of pathogens causing community-acquired urinary tract infections in Russia: results of the multicenter study “DARMIS-2018”

Cited by 31 publications

References 7 publications

AMRmap: An Interactive Web Platform for Analysis of Antimicrobial Resistance Surveillance Data in Russia

AMRmap: An Interactive Web Platform for Analysis of Antimicrobial Resistance Surveillance Data in Russia

War and Peace: the difficult treatment of urinary tract infections and fosfomycin trometamol

Investigation of the activity of new derivatives of 1,3-diazinone-4 and their acyclic precursors with respect to bacteria of the genus Proteus

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