Antimicrobial resistance of Neisseria gonorrhoeae in Japan, 1993–2002: continuous increasing of ciprofloxacin-resistant isolates

Tanaka, Masatoshi; Nakayama, Hiroshi; Notomi, Takashi; Irie, Shinichiro; Tsunoda, Yuichi; Okadome, Aya; Saika, Takeshi; Kobayashi, Ichiro

doi:10.1016/j.ijantimicag.2004.02.005

Cited by 57 publications

(70 citation statements)

References 12 publications

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“…However, a few N. gonorrhoeae isolates with decreased susceptibility or resistance to ciprofloxacin that lack substitutions in the QRDR of the gyrA gene as well as in the parC gene have previously been described (40-42). These very rare isolates result in discrepancies between phenotypic and genetic ciprofloxacin susceptibility testing and may be due to polymorphisms in other regions of the gyrA gene or parC gene, or polymorphisms in other genes such as the porB gene (20,40,(43)(44)(45). Whilst culture remains the gold standard for diagnosis of N. gonorrhoeae, an increasing number of laboratories are using molecular methods for diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Molecular characterization of Neisseria gonorrhoeae identifies transmission and resistance of one ciprofloxacin‐resistant strain

Unemo

Sjöstrand

Akhras

et al. 2007

APMIS

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A highly discriminative and objective genetic characterization of N. gonorrhoeae, which increases our knowledge of strain populations in different geographic areas, is crucial for the development of improved control measures. In the present study, conventional phenotypic characterization and genetic characterization by means of pulsed-field gel electrophoresis (PFGE), sequencing of the entire porB gene, N. gonorrhoeae multiantigen sequence typing (NG-MAST), and pyrosequencing of a quinolone resistance determining region (QRDR) of the gyrA gene of Swedish ciprofloxacinresistant N. gonorrhoeae serovar IB-10 isolates (n=45) were performed. The genetic characterization identified one widely spread ciprofloxacin-resistant N. gonorrhoeae ST147 strain. In addition, isolates with slightly different genetic characteristics, which presumably reflect the ongoing evolution only, were also identified. All the isolates contained single nucleotide polymorphisms in QRDR of the gyrA gene that are highly correlated with ciprofloxacin resistance. Consequently, comprehensive characterization identified the first confirmed large domestic transmission, mainly among young heterosexuals, of one ciprofloxacin-resistant N. gonorrhoeae strain in Swedish society during [2002][2003]. In conclusion, a precise, i.e. genetic, characterization for identification of individual strains is a very valuable support to the crucial active surveillance of the epidemiological characteristics and the antibiotic susceptibility of N. gonorrhoeae in the effective treatment of gonorrhoea. KeywordsNeisseria gonorrhoeae; ciprofloxacin resistance; molecular epidemiology; porB gene; NG-MAST Gonorrhoea remains a major sexually transmitted infection (STI) in many countries (1,2). The mainstay in its prevention is based on the availability of effective diagnostics and antibiotic treatment, as well as regional, national, and international surveillance of the epidemiological characteristics and the antibiotic susceptibility of the etiological agent, i.e. Neisseria gonorrhoeae. Nowadays, a high level of decreased susceptibility or resistance to most traditional antibiotics used for treatment of gonorrhoea has been identified in most countries [2][3][4][5]). In addition, the characteristics of circulating N. gonorrhoeae strains fluctuate over time and a highly discriminative and objective characterization, i.e. genetic typing, of the bacteria, is crucial. This genetic typing may identify the transmission of more virulent and/or antibiotic-resistant strains, information that is important for the development of improved control measures. Conventional phenotypic characterization of N. gonorrhoeae strains has several limitations (6-10) and many genetic methods have been developed to overcome these shortcomings (11).Since 1997 the incidence of gonorrhoea in Sweden has increased almost annually (Gonorrhoea/ year and month statistics per county http://gis.smittskyddsinstitutet.se/mapapp/build/intro_eng.html (3,8)). According to previous studies (8,10,12), the transmi...

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Section: Discussionmentioning

confidence: 99%

Molecular characterization of Neisseria gonorrhoeae identifies transmission and resistance of one ciprofloxacin‐resistant strain

Unemo

Sjöstrand

Akhras

et al. 2007

APMIS

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“…12,16,17 However, in the last few years, a high prevalence of fluoroquinolone-resistant N. gonorrhoeae isolates has been reported in Japan. 1,2,4,9 In addition, N. gonorrhoeae isolates have evolved in acquiring multidrug-resistance not only to fluoroquinolone, but also to penicillin and tetracycline. 9,11 With this rising incidence of -resistant N. gonorrhoeae strains in mind, antibiotics should be chosen carefully and confirmatory sensitivity tests ought to be performed.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, N. gonorrhoeae has recently shown increased resistance to antimicrobial agents. 1,2,4,[9][10][11] Such delays in attaining a correct diagnosis, and increased resistance can result in the development of keratitis with severe corneal involvement.…”

Section: Introductionmentioning

confidence: 99%

Surgical management of corneal perforation secondary to gonococcal keratoconjunctivitis

Kawashima

Kawakita

Den

et al. 2007

Eye

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Aims To report five cases of gonococcal keratoconjunctivitis with severe corneal involvement treated with therapeutic keratoplasty. Design Retrospective case series. Methods Five consecutive cases of gonococcal keratoconjunctivitis treated with keratoplasty for corneal perforation, with a mean age of 21.2 years, were analysed by patient's history, surgical approaches, and clinical outcomes, corrected visual acuity at initial visit and last follow-up.

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“…72,73 In the USA the gonococcal isolate surveillance programme (GISP) report for 1997 recorded, overall, the presence of 33.4% of strains resistant to the penicillin, tetracycline, or both. Resistance to fluoroquinolones, one of the currently recommended treatments for gonorrhoea, is rare with the exception of Ohio State in which decreased susceptibility persists at 16%.…”

Section: Prevention Of Stismentioning

confidence: 99%

Evaluating the chlamydia and gonorrhoea screening program in the Humanitarian Entrant Health Service, Western Australia

Hoad¹,

Thambiran²

2012

Medical Journal of Australia

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Objectives: To document the prevalence of Chlamydia trachomatis and Neisseria gonorrhoeae in the refugee population settling in Western Australia from 1 January 2006 to 31 December 2009 and make recommendations for future screening for chlamydia and gonorrhoea in the refugee population. Design and participants: A prevalence and quality assurance study of 2610 refugees aged 15 years and older who attended the Humanitarian Entrant Health Service in Western Australia and were screened for chlamydia and gonorrhoea. Main outcome measures: Demographic details and results of C. trachomatis and N. gonorrhoeae tests on first void urine. Results: The prevalence of chlamydia was found to be 0.8% (n = 21) in the refugee population. No gonorrhoea infections were detected. The prevalence of chlamydia was low (0.19%–1.23%) when analysed by sex, ethnicity or age and was considerably lower than other subpopulations considered high risk in Australia. Conclusion: The low prevalence rates of chlamydia and gonorrhoea found in the refugee population suggest that current screening guidelines should be updated. We recommend screening all refugees who are sexually active up to age 39 years, taking into account an appropriate sexual history; otherwise, screening guidelines should be as for the general Australian population.

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Antimicrobial resistance of Neisseria gonorrhoeae in Japan, 1993–2002: continuous increasing of ciprofloxacin-resistant isolates

Cited by 57 publications

References 12 publications

Molecular characterization of Neisseria gonorrhoeae identifies transmission and resistance of one ciprofloxacin‐resistant strain

Molecular characterization of Neisseria gonorrhoeae identifies transmission and resistance of one ciprofloxacin‐resistant strain

Surgical management of corneal perforation secondary to gonococcal keratoconjunctivitis

Evaluating the chlamydia and gonorrhoea screening program in the Humanitarian Entrant Health Service, Western Australia

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