ANTIMICROBIAL RESISTANCE OF NEISSERIA GONORRHOEA IN BANGKOK: IS SINGLE-DRUG TREATMENT PHASSt

Brown, Stuart T.; Biddle, James W.; Warnnissorn, Tumnoon; Panikabutra, K; Traisupa, Amnuay

doi:10.1016/s0140-6736(82)91271-5

Cited by 59 publications

(17 citation statements)

References 14 publications

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“…Previous researchers have documented the resistance of N. gonorrhoeae to both penicillin and tetracycline in Thailand (2). While the prevalence of ,B-lactamase-producing strains appears to have declined from the 45% (reported in 1983) to 50% (reported in 1988), in the present study, 94 of 333 (28.2%) isolates produced ,-lactamase (14,15).…”

Section: Discussioncontrasting

confidence: 40%

Antibiotic susceptibility survey of Neisseria gonorrhoeae in Thailand

Clendennen

Echeverria

Saengeur

et al. 1992

Antimicrob Agents Chemother

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The antibiotic susceptibilities of Neisseria gonorrhoeae isolates obtained from patients attending sexually transmitted disease clinics in Cholburi and Bangkok, Thailand, were determined by agar dilution. Some 28.2% of isolates produced 13-lactamase. A total of 97.9% of 13-lactamase-positive and 51% of 1-lactamase-negative isolates tested were resistant to penicillin (MICs, 22 ,ug/ml), 70%o of isolates tested were resistant to tetracycline (MICs, >2 ug/ml), and 91% of isolates tested were susceptible to spectinomycin (MICs, c64 ,ug/ml). The MICs for 90% of isolates for the other drugs tested were 2 ,ug/ml for erythromycin, 2 img/ml for cefoxitin, 1 p,g/ml for cefuroxime, 0.125 ,ug/ml for cefpodoxime, 0.06 ,ug/ml for cefotaxime, 0.25 ,ug/ml for ceftazidime, 0.03 ,ug/ml for ceftizoxime, 0.03 ,ug/ml for ceftriaxone, 0.03 ,ug/ml for cefixime, 0.06 ,ug/ml for aztreonam, 0.008 ,ug/ml for ciprofloxacin, 0.125 p,g/ml for norfloxacin, and 0.075 ,ug/ml for ofloxacin. Fewer than 1.5% of isolates were resistant to the extended-spectrum cephalosporins tested. Some 0.3% or fewer isolates were resistant to broad-spectrum cephalosporins, fluoroquinolones, or the monobactam aztreonam.

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Section: Discussioncontrasting

confidence: 40%

Antibiotic susceptibility survey of Neisseria gonorrhoeae in Thailand

Clendennen

Echeverria

Saengeur

et al. 1992

Antimicrob Agents Chemother

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“…In vitro studies revealed that several new /J-lactam antibiotics may also serve this purpose [4,[14][15][16]. Our data support the use of spectinomycin, as none of the strains were resistant using 32 mg/1 as break point between resistant and sensi tive strains.…”

Section: Discussionsupporting

confidence: 62%

Activity of Nine Antibacterial Agents on Penicillinase- and Nonpenicillinase-Producing <i>Neisseria gonorrhoeae</i> Isolated from Clinical Specimens Obtained in Northern Norway

et al. 1985

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34 penicillinase-producing (PPNG) and 102 nonpenicillinase producing (non-PPNG) strains of Neisseria gonorrhoeae were tested against 9 antibacterial agents. Cefoxitin, latamoxef, cefotaxime and imipenem inhibited all PPNG (MIC < 2 mg/l); chloramphenicol (2 mg/l) inhibited 86%, and 3% and 8%, respectively, were inhibited by 1 mg/1 of doxycycline when disk diffusion or agar dilution sensitivity testing were performed. All PPNG strains were sensitive to spectinomycin (MIC < 32 mg/l). Non-PPNG strains were uniformly sensitive to all antibacterial agents, doxycycline being slightly less active than the other compounds.

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“…We collected samples with disposable loops and inoculated them direct on to neisserial selective medium consisting of GC agar base (BBL), 1% IsoVitalex, and vancomycin (3 mg/l), colistin (1000 u/l), trimethoprim (5 …”

Section: Isolation and Identificationmentioning

confidence: 99%

Chromosomal resistance of gonococci to antibiotics.

Ison

Gedney²,

Easmon³

1987

Sexually Transmitted Infections

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SUMMARY Three hundred and twenty nine strains of non-penicillinase-producing Neisseria gonorrhoeae (non-PPNG) isolated from men and women were tested for their susceptibility to a range of antibiotics, and were also auxotyped and serogrouped. Nearly 6% (18) of 312 strains tested were resistant to 1 mg/l or more penicillin (compared with 4.4% of PPNG strains isolated in 1981). Many (198, 64%) strains showed intermediate resistance to penicillin (0.12-0.5 mg/l). Nearly 5% (15) of 312 strains tested were resistant to 0.5 mg/l or more cefuroxime, and there was a high degree of cross resistance between these two antibiotics. High levels of resistance to erythromycin and tetracycline were also found, and there was also appreciable cross resistance between these antibiotics and the ,B lactam drugs. Resistance to spectinomycin was rare, and there was no cross resistance between spectinomycin and other agents tested. Levels of resistance between -strains isolated from different anatomical sites did not differ, except that resistance to erythromycin was greater in rectal isolates. Four main auxotypes were detected. Strains requiring arginine, hypoxanthine, and uracil (AHU -) were more prevalent from the cervix. We have shown that there is an association between auxotype, serogroup, and level of sensitivity to penicillin, cefuroxime, and tetracycline.The epidemiology and treatment of infections caused by penicillinase producing strains of Neisseria gonorrhoeae (PPNG) have been major concerns since the first description of these strains in 1976.1 2 The prevalence of infections with PPNG strains is highest in Africa and the Far East. In the United Kingdom the increase in the prevalence of PPNG strains was rapid between 1980 and 1983, but now appears to have slowed.3 Our own experience with PPNG strains isolated from patients attending the Praed Street Clinic mirrors that seen nationally, and we saw a decline in prevalence of PPNG strains in 1985.4 Though the problem of PPNG strains has been more spectacular, resistance to antibiotics in non-PPNG strains has continued to grow, particularly in the Far East. In Thailand more than half the non-PPNG strains are resistant to 1 mg/I or more benzylpenicillin, and 21% are resistant to 0.5 mg/l or more cefuroxime~;5 Resistance to penicillin in non-PPNG strains results from chromosomal mutations at multiple loci, each producing small increments in resistance. Some loci are specific for penicillin resistance (pen A), others mediate resistance to a

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ANTIMICROBIAL RESISTANCE OF NEISSERIA GONORRHOEA IN BANGKOK: IS SINGLE-DRUG TREATMENT PHASSt

Cited by 59 publications

References 14 publications

Antibiotic susceptibility survey of Neisseria gonorrhoeae in Thailand

Antibiotic susceptibility survey of Neisseria gonorrhoeae in Thailand

Activity of Nine Antibacterial Agents on Penicillinase- and Nonpenicillinase-Producing <i>Neisseria gonorrhoeae</i> Isolated from Clinical Specimens Obtained in Northern Norway

Chromosomal resistance of gonococci to antibiotics.

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