Antimicrobial resistance of bacterial isolates from respiratory care wards in Taiwan: a horizontal surveillance study comparison of the characteristics of nosocomial infection and antimicrobial-resistant bacteria in adult Intensive Care Units and two respiratory care facilities for mechanically ventilated patients at a tertiary care centre in Taiwan

Liu, Keh-Sen; Lai, Yi‐Chyi; Yu, Su-Fang; Huang, Shu-Ju; Huang, Huey-Jen; Lu, Min-Chi; Hsueh, Po-Ren

doi:10.1016/j.ijantimicag.2010.07.020

Cited by 10 publications

(6 citation statements)

References 45 publications

(68 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…aeruginosa was the leading NFGNB that caused nosocomial NFGNB bacteremia. 3,20 Increasing prevalence of multidrug resistant P. aeruginosa even worsened the clinical treatment, with increased mortality rate in bacteremic patients. 4,8,21e24 Chromosomally encoding both RmtD methylase and metallo-b-lactamases genes have also been found leading to pan-drug resistant P. aeruginosa.…”

Section: Discussionmentioning

confidence: 99%

“…The mortality rate attributed to NFGNB bacteremia could be as high as 25%. 2,3 Among NFGNB, Pseudomonas aeruginosa, Acinetobacter baumannii complex, and Stenotrophomonas maltophilia were the most common pathogens causing healthcare-associated bloodstream infections. 3 NFGNB are easily resistant to most of the beta-lactam antibiotics through beta-lactamase production, impermeability, and multidrug efflux pumps.…”

Section: Introductionmentioning

confidence: 99%

“…2,3 Among NFGNB, Pseudomonas aeruginosa, Acinetobacter baumannii complex, and Stenotrophomonas maltophilia were the most common pathogens causing healthcare-associated bloodstream infections. 3 NFGNB are easily resistant to most of the beta-lactam antibiotics through beta-lactamase production, impermeability, and multidrug efflux pumps. 4 The emerging resistance of NFGNB to all commonly used antibiotics may lead to inappropriate administration of empirical antibiotics, which contributes to the high fatality rate of NFGNB bacteremia.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

In vitro activity of aminoglycosides against clinical isolates of Acinetobacter baumannii complex and other nonfermentative Gram-negative bacilli causing healthcare-associated bloodstream infections in Taiwan

Liu

Wang

et al. 2016

Journal of Microbiology, Immunology and Infection

View full text Add to dashboard Cite

Background/Purpose: Aminoglycosides possess in vitro activity against aerobic and facultative Gram-negative bacilli. However, nationwide surveillance on susceptibility data of Acinetobacter baumannii complex and Pseudomonas aeruginosa to aminoglycosides was limited, and aminoglycoside resistance has emerged in the past decade. We study the in vitro susceptibility of A. baumannii complex and other nonfermentative Gram-negative bacilli (NFGNB) to aminoglycosides. Methods: A total of 378 NFGNB blood isolates causing healthcare-associated bloodstream infections during 2008 and 2013 at four medical centers in Taiwan were tested for their susceptibilities to four aminoglycosides using the agar dilution method (gentamicin, amikacin, tobramycin, and isepamicin) and disc diffusion method (isepamicin). Please cite this article in press as: Liu J-Y, et al., In vitro activity of aminoglycosides against clinical isolates of Acinetobacter baumannii complex and other nonfermentative Gram-negative bacilli causing healthcare-associated bloodstream infections in Taiwan, Journal of Microbiology, Immunology and Infection (2015), http://dx.Journal of Microbiology, Immunology and Infection (2015) xx, 1e6 nonfermentativeGram-negative bacilli Results: A. baumannii was highly resistant to all four aminoglycosides (range of susceptibility, 0e4%), whereas >80% of Acinetobacter nosocomialis and Acinetobacter pittii blood isolates were susceptible to amikacin (susceptibility: 96% and 91%, respectively), tobramycin (susceptibility: 92% and 80%, respectively), and isepamicin (susceptibility: 96% and 80%, respectively). All aminoglycosides except gentamicin possessed good in vitro activity (>94%) against P. aeruginosa. Amikacin has the best in vitro activity against P. aeruginosa (susceptibility, 98%), followed by A. nosocomialis (96%), and A. pittii (91%), whereas tobramycin and isepamicin were less potent against A. pittii (both 80%). Aminoglycoside resistances were prevalent in Stenotrophomonas maltophilia and Burkholderia cepacia complex blood isolates in Taiwan. Conclusion: Genospecies among the A. baumannii complex had heterogeneous susceptibility profiles to aminoglycosides. Aminoglycosides, except gentamicin, remained good in vitro antimicrobial activity against P. aeruginosa. Further in vivo clinical data and continuous resistance monitoring are warranted for clinical practice guidance.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

In vitro activity of aminoglycosides against clinical isolates of Acinetobacter baumannii complex and other nonfermentative Gram-negative bacilli causing healthcare-associated bloodstream infections in Taiwan

Liu

Wang

et al. 2016

Journal of Microbiology, Immunology and Infection

View full text Add to dashboard Cite

show abstract

“…They have become the main pathogens in the intensive care unit of neurology, and patients infected by such strains are mostly of poor prognosis. [12] In the treatment of gram-negative nonfermentative bacilli, antimicrobial drugs should be used rationally according to the drug susceptibility results. The targeted gene transfer vector system can deliver a gene to specific target cells.…”

Section: Discussionmentioning

confidence: 99%

Risk assessment of ischemic stroke associated pneumonia

Li¹,

Zhang²,

Wu-ping³

et al. 2014

World Journal of Emergency Medicine

View full text Add to dashboard Cite

BACKGROUND: Cerebral stroke is a disease with a high disability rate and a high fatality rate. This study was undertaken to assess the risk of stroke associated pneumonia (SAP) in patients with ischemic stroke using A2DS2 score. METHODS:Altogether 1 279 patients with ischemic stroke who were treated in our department from 2009 to 2011 were retrospectively analyzed with A2DS2 score. A2DS2 score was calculated as follows: age ≥75 years=1, atrial fi brillation=1, dysphagia=2, male sex=1; stroke severity: NIHSS score 0-4=0, 5-15=3, ≥16=5. The patients were divided into three groups according to A2DS2 score: 620 in score 0 group, 383 in score 1-9 group, and 276 in score ≥10 group. The three groups were comparatively analyzed. The diagnostic criteria for SAP were as follows: newly emerging lesions or progressively infiltrating lesions on post-stroke chest images combined with more than two of the following clinical symptoms of infection: (1) fever ≥38 °C; (2) newly occurred cough, productive cough or exacerbation of preexisting respiratory tract symptoms with or without chest pain; (3) signs of pulmonary consolidation and/or wet rales; (4) peripheral white blood cell count ≥10×10 9 /L or ≤4×10 9 /L with or without nuclear shift to left, while excluding some diseases with clinical manifestations similar to pneumonia, such as tuberculosis, pulmonary tumors, non-infectious interstitial lung disease, pulmonary edema, pulmonary embolism and atelectasis. The incidence and mortality of SAP as well as the correlation with ischemic stroke site were analyzed in the three groups respectively. Mean± standard deviation was used to represent measurement data with normal distribution and Student's t test was used. The chi-square test was used to calculate the percentage for enumeration data. RESULTS:The incidence of SAP was significantly higher in the A2DS2 score≥10 group than that in the score 1-9 and score 0 groups (71.7% vs. 22.7%, 71.7% vs. 3.7%, respectively), whereas the mortality in the score≥10 group was signifi cantly higher than that in the score 1-9 and score 0 groups (16.7% vs. 4.96%, 16.7% vs. 0.3%, respectively). The incidences of cerebral infarction in posterior circulation and cross-MCA, ACA distribution areas were signifi cantly higher than those in the SAP group and in the non-SAP group (35.1% vs.10.1%, 11.4% vs. 7.5%, respectively). The incidence of non-fermentative bacteria infection was signifi cantly increased in the score≥10 group.CONCLUSIONS: A2DS2 score provides a basis for risk stratifi cation of SAP. The prevention of SAP needs to be strengthened in acute ischemic stroke patients with a A2DS2 score≥10.

show abstract

“…Previous studies in Taiwan reported that patients in RCWs had a higher incidence of ESBL-producing Enterobacteriaceae infection or colonization than those in intensive care units (Kuo et al ., 2008; Liu et al ., 2011). However, the reasons for this remain unclear.…”

Section: Discussionmentioning

confidence: 99%

Prolonged clonal spreading and dynamic changes in antimicrobial resistance of Escherichia coli ST68 among patients who stayed in a respiratory care ward

Chen

et al. 2014

Journal of Medical Microbiology

View full text Add to dashboard Cite

The Third Branch, Centers for Diseases Control, Taichung, TaiwanFrom 2007 to 2009, we collected a total of 83 bacteraemic isolates of Escherichia coli with reduced susceptibility or resistance to third-generation cephalosporins (TGCs). Isolates were genotyped by PFGE and multilocus sequence typing (MLST). The PFGE patterns revealed two highly correlated clusters (cluster E: nine isolates; cluster G: 22 isolates) associated with this prolonged clonal spreading. Compared with cluster E isolates, cluster G isolates were significantly more likely to harbour aac(6')-Ib-cr (P,0.05), and most of these isolates were isolated during a later year than cluster E isolates (P,0.05). By MLST analysis, 94 % of cluster E and G isolates (29/31) were ST68. Although no time or space clustering could be identified by the conventional hospital-acquired infection monitoring system, E. coli cases caused by cluster E and G isolates were significantly associated with having stayed in our hospital's respiratory care ward (P,0.05). Isolates obtained from patients who had stayed in the respiratory care ward had a significantly higher rate of aac(6')-Ib-cr and bla CTX-M-14 positivity, and were more likely to belong to ST68/S68-like (all P,0.05). To our knowledge, this is the first report of prolonged clonal spreading caused by E. coli ST68 associated with a stay in a long-term care facility. Using epidemiological investigations and PFGE and MLST analyses, we have identified long-term clonal spreading caused by E. coli ST68, with extra antimicrobial-resistance genes possibly acquired during the prolonged spreading period.

show abstract

Cited by 10 publications

References 45 publications

In vitro activity of aminoglycosides against clinical isolates of Acinetobacter baumannii complex and other nonfermentative Gram-negative bacilli causing healthcare-associated bloodstream infections in Taiwan

In vitro activity of aminoglycosides against clinical isolates of Acinetobacter baumannii complex and other nonfermentative Gram-negative bacilli causing healthcare-associated bloodstream infections in Taiwan

Risk assessment of ischemic stroke associated pneumonia

Prolonged clonal spreading and dynamic changes in antimicrobial resistance of Escherichia coli ST68 among patients who stayed in a respiratory care ward

Contact Info

Product

Resources

About