Antimicrobial Resistance in Nontyphoidal Salmonella

Alcaine, Samuel D.; Warnick, Lorin D.; Wiedmann, Martin

doi:10.4315/0362-028x-70.3.780

Cited by 113 publications

(102 citation statements)

References 113 publications

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“…Although generally the isolated strains were susceptible to all antimicrobials tested, the resistance analysis revealed that only one S. Typhimurium isolate identified in the present study showed a multidrug resistance pattern (AMP, STR, TET, and SMX), defined as resistance to three or more antimicrobial classes (1,10). According to the recent EFSA report (10), such strains (n = 107) of cattle origin were mainly resistant to TET (52.3%), AMP (45.8%), and sulfonamides (57.9%).…”

Section: Discussionmentioning

confidence: 63%

“…It has been shown that the presence of S. Typhimurium in cattle and the consequent cross contamination of beef carcasses are of particular concern since this serotype is one of the most common causes of human salmonellosis in many countries (3,5,9,20,21). Furthermore, many such strains have developed resistance to several antimicrobial agents (1).…”

Section: Introductionmentioning

confidence: 99%

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Prevalence and characterisation of Salmonella in slaughtered cattle and beef in Poland

Wieczorek

Osek

2013

Bulletin of the Veterinary Institute in Pulawy

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A total of 1229 samples, including 406 bovine hides and 406 corresponding carcasses at the slaughter level, as well as 417 beef meat from local supermarkets, were tested for the presence of Salmonella sp. Eighteen (1.5%) samples were positive for the target microorganism, and the highest prevalence (2.2%) was found in meat, followed by carcasses (1.2%) and hides (1.0%). Among the isolated strains, Salmonella enterica serotypes Enteritidis (six isolates) and Schleissheim (six strains), followed by Dublin (four contaminated samples) were the most predominant. The antimicrobial resistance analysis against nine antimicrobials with the MIC technique revealed that most isolates were sensitive to all antibacterial agents. However, one S. Typhimurium of carcass origin was multidrug resistant, and displayed the resistance to four antimicrobials, i.e. ampicillin, streptomycin, tetracycline, and sulphametoxazole. Furthermore, one S. Enteritidis (from carcasses), two S. Dublin (of beef origin), and one S. London (from meat) strains were resistant to sulphametoxazole. The restriction enzyme analysis with XbaI resulted in eight different PFGE types. The obtained results suggest that cattle may be an underestimated source of pathogenic Salmonella for consumers.

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Section: Discussionmentioning

confidence: 63%

Section: Introductionmentioning

confidence: 99%

Prevalence and characterisation of Salmonella in slaughtered cattle and beef in Poland

Wieczorek

Osek

2013

Bulletin of the Veterinary Institute in Pulawy

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“…Genes conferring resistance to amikacin (aacA4), ampicillin (oxa1), chloramphenicol (catB3), kanamycin (aadB), gentamicin (aadB, aaC1), streptomycin (aadA1a), sulfonamides (sulI), and trimethoprim (dhfrI) have been identified on integron-associated gene cassettes of Salmonella isolated from human and animal sources (Daly and Fanning 2000;Tosini et al 1998). Alcaine and colleagues provide an extensive review of antimicrobial resistance mechanisms of Salmonella and associated resistance genes (Alcaine et al 2007). …”

Section: Antimicrobial Resistancementioning

confidence: 99%

Antimicrobial resistant Salmonella in dairy cattle in the United States

2008

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Increased frequency of antimicrobial resistant Salmonella isolated from humans over the last quarter century in the United States has led to concern about the contribution animal production systems have played in the emergence and spread of antimicrobial resistant Salmonella. In order to better understand the potential role of dairy cattle as a reservoir for antimicrobial resistant Salmonella, it is important to understand methods currently used to measure the prevalence of antimicrobial resistance among Salmonella from human and animal populations. This review describes the biology of Salmonella and antimicrobial resistance, methods used to monitor antimicrobial resistance, and studies that have measured the prevalence of antimicrobial resistant Salmonella among human and dairy cattle populations in the U.S. Although the prevalence of antimicrobial resistance among Salmonella from healthy dairy cattle is low, similar trends in the prevalence of resistance among Salmonella from clinically ill human and dairy cattle populations were observed in the literature.

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“…These multidrug-resistant (MDR) S. enterica strains (defined as strains that are resistant to two or more antimicrobial agents) may carry their resistance determinants on chromosomal locations, on resistance plasmids, or on both (3,23,52). Of particular importance to the medical community are resistances to the extended-spectrum cephalosporin ceftriaxone, the drug of choice for treatment of pediatric salmonellosis, and to the quinolone nalidixic acid and the fluoroquinolone ciprofloxacin, which are preferable for treatment of adults (42).…”

mentioning

confidence: 99%

Diversity of Multidrug-Resistant Salmonella enterica Strains Associated with Cattle at Harvest in the United States

Brichta-Harhay

Arthur

Bosilevac

et al. 2011

Appl Environ Microbiol

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The prevalence and diversity of multidrug-resistant (MDR) Salmonella enterica strains associated with cattle at harvest in the United States were examined. Hides and carcasses of cattle were sampled at processing plants (n ‫؍‬ 6) located in four geographically distant regions from July 2005 to April 2006. The mean prevalences of Salmonella on hides, preevisceration carcasses (immediately after hide removal), and postintervention carcasses (in the chiller and after the full complement of interventions) were 89.6%, 50.2%, and 0.8%, respectively. The values for MDR Salmonella enterica strains (defined as those resistant to two or more antimicrobials) as percentages of Salmonella prevalence were 16.7% (95% confidence interval [CI], 8.3 to 25.1%; median percent prevalence, 6.9%), 11.7% (95% CI, 4.4 to 19.0%; median, 4.8%), and 0.33% (95% CI, ؊0.3 to 0.70%; median, 0%), respectively. In this study, 16,218 Salmonella hide and carcass isolates were screened for antimicrobial resistance. Of these, 978 (6.0%) unique MDR S. enterica isolates were identified and serotyped and their XbaI pulsed-field gel electrophoresis (PFGE) profiles determined. The predominant MDR S. enterica serotypes observed were Newport (53.1%), Typhimurium (16.6%), and Uganda (10.9%). Differences in MDR S. enterica prevalence were detected, and PFGE analysis revealed both epidemic clusters (profiles found in plants in multiple regions/seasons) and endemic clusters (profiles observed in plants in limited regions/seasons) within several of the MDR serotypes examined. Despite these differences, multiple-hurdle processing interventions employed at all plants were found to be quite effective and decreased Salmonella carcass contamination by 98.4% (95% CI, 97.6 to 99.7%).

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Antimicrobial Resistance in Nontyphoidal Salmonella

Cited by 113 publications

References 113 publications

Prevalence and characterisation of Salmonella in slaughtered cattle and beef in Poland

Prevalence and characterisation of Salmonella in slaughtered cattle and beef in Poland

Antimicrobial resistant Salmonella in dairy cattle in the United States

Diversity of Multidrug-Resistant Salmonella enterica Strains Associated with Cattle at Harvest in the United States

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