Antimicrobial Resistance in Invasive and Colonising Streptococcus Pneumoniae in North India

Goyal, Renu; Singh, Neelam; Kaur, Maninder; Talwar, V.

doi:10.1016/s0255-0857(21)02117-4

Cited by 4 publications

(2 citation statements)

References 6 publications

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“…Continuous surveillance of the susceptibility patterns of S. pneumoniae in carriers becomes increasingly important because of the increasing emergence of antibiotic-resistant strains worldwide [41]. The antibiotic susceptibility of S. pneumoniae isolated from infants 'nasopharynx reflected alarming rates of resistance to most of the antibiotics tested.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Pneumococcal Carriage among Jordanian Infants in the First 6 Months of Age, 2008–2016

Al‐Lahham¹

2021

Vaccines

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Background: Streptococcus pneumoniae is an opportunistic human-adapted pathogen driven by nasopharyngeal carriage. Aims: To find the pneumococcal carriage rate, resistance, serotypes, and coverage of pneumococcal conjugate vaccines (PCVs) among infants in the first six months of age in the period from March 2008 to April 2016. Methods: Nasopharyngeal swabs (NP) were taken from healthy infants from the northern part of Jordan. Swabs were processed for cultivation, identification, resistance testing and serotyping according to standard methods. Results: During the surveillance period, 484 infants of this age group were tested, with a total carriage rate of 56.2%. 96.2% of infants one to two months of age got one PCV7 injection and were 58% carriers at the time of the first injection. At age three to four months, 84.9% had received two injections, with a carriage rate of 54.9% at the time of the second injection. At ages five to six months, 12.5% had received one to three injections, with a carriage rate of 43.8%. Predominant serotypes in all age groups were 19F (12.5%), 6A (11.4%), 11A (8.4%), 19A (7.0%), 6B (6.6%), 23F (5.9%), 15B (5.1%), 15A and 23A (4.0% each). Coverage of PCV7, PCV13 and the future PCV20 among all cases were 30.5%, 50.7% and 70.6%, respectively. The highest coverage rate of 78.6% was noticed in the age group at five to six months with the future PCV20. Antibiotic resistance was the highest in the first age group. Conclusions: Pneumococcal carriage starts from the first month of the infant’s life. The highest coverage was noticed for PCV20, which implies the necessity for inoculation with future vaccines.

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Section: Discussionmentioning

confidence: 99%

Prevalence of Pneumococcal Carriage among Jordanian Infants in the First 6 Months of Age, 2008–2016

Al‐Lahham¹

2021

Vaccines

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“…30 The literature reported PRSP ranges from 4.6% to 50.7% in India for penicillin (oral) based on EUCAST criteria. [31][32][33][34] During PRSP development, the most of the penicillin resistant and susceptible S. pneumoniae strains were susceptible to carbapenems and fluoroquinolones. 35 S. pneumoniae and H. influenzae remain among a major cause of various community-acquired respiratory tract infections.…”

Section: Present Scenario Of Amoxicillin+clavulanic Acid In Cap In Indiamentioning

confidence: 99%

Amoxicillin+clavulanic acid in community acquired pneumonia: Past, present, and future from an Indian perspective

et al. 2022

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Community acquired pneumonia (CAP) is a major health problem in India with high morbidity and mortality. The threat posed by this infection is further intensified by the continued emergence of resistance to the currently available antibiotics. With a heritage of more than 24 years in India, amoxicillin+clavulanic acid is one of the most common antibiotics used for CAP. It was developed with an intent to sustain the efficacy of amoxicillin which was challenged due to the emergence of the beta-lactamase producing microorganism. Over a period, it has been included in national and international guidelines for the treatment of CAP. To assure the highest probability of clinical cure and to combat development of resistance: It is imperative for amoxicillin+clavulanic acid to reaffirm itself. Optimization of the PK/PD and higher dose of amoxicllin+clavulanic acid will tackle the burden of the future difficult to manage respiratory infections.

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Detection of pneumolysin and autolysin genes among antibiotic resistant Streptococcus pneumoniae in invasive infections

Sourav

Patrícia

Sharma

et al. 2010

Indian Journal of Medical Microbiology

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Emerging resistance observed for cefepime and ceftriaxone might be due their increased and frequent usage nowadays. Presence of pneumolysin appears to be more critical for pathogenesis of invasive infections than the ocular infections. However, presence of lytA gene in all the isolates signifies that irrespective of site of isolation, kind of infection caused, autolysin is an obligate necessity for this organism.

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Antimicrobial Resistance in Invasive and Colonising Streptococcus Pneumoniae in North India

Cited by 4 publications

References 6 publications

Prevalence of Pneumococcal Carriage among Jordanian Infants in the First 6 Months of Age, 2008–2016

Prevalence of Pneumococcal Carriage among Jordanian Infants in the First 6 Months of Age, 2008–2016

Amoxicillin+clavulanic acid in community acquired pneumonia: Past, present, and future from an Indian perspective

Detection of pneumolysin and autolysin genes among antibiotic resistant Streptococcus pneumoniae in invasive infections

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