Antimicrobial resistance in bacterial pathogens among hospitalized children with community acquired lower respiratory tract infections in Dongguan, China (2011–2016)

Abstract

BackgroundBacterial pathogens are a major cause of childhood community acquired lower respiratory tract infections (CA-LRTIs), and few data described the impact of antimicrobial resistance on children with CA-LRTIs. This study aims to investigate the antimicrobial resistance in common bacterial agents among hospitalized children with CA-LRTIs between 2011 and 2016 in Dongguan, China.MethodsSputum samples were collected from hospitalized children (0–5 years old) with CA-LRTIs in Dongguan Children’s Hospital. Bacterial pathogens were detected using traditional culture methods, and disc diffusion tests were used to determine antibiotic resistance.ResultsAmong the 2360 samples analyzed, 342 (14.5%) were positive for bacterial infection. The most prevalent pathogen was MSSA (2.3%), followed by MRSA (1.5%), E. coli (1.7%), E. coli ESBLs (1.2%), K. pneumonia ESBLs (1.5%), K. pneumonia (1.4%) and S. pneumonia (1.3%). Of the hospitalized patients with bacteria causing of CA-LRTIs, 90.1% were less than 1-year-old. MSSA and MRSA were more commonly isolated in infants less than 3 months. E. coli, K. pneumonia and K. pneumonia ESBLs were more common bacteria causing CA-LRTIs in infants less than 1 month. Resistance levels to penicillins, fluoroquinolones, macrolides, cephalosporins, carbapenems and vancomycin varied in different bacteria.Conclusions S. aureus, E coli and K. pneumonia were the common bacterial isolates recovered from chidren with CA-LTRIs during 2011–2015. Age group of under 1 year old was at a high risk of bacterial infections. Many isolates showed antibiotic resistance level was associated with antibiotic usage in clinic. Increasing surveillance of antibiotic resistance is urgently needed and develops better strategies to cure the antibiotic abuse in China.

<p>Antimicrobial resistance, virulence genes profiling and molecular relatedness of methicillin-resistant <em>Staphylococcus aureus</em> strains isolated from hospitalized patients in Guangdong Province, China</p>

“…The prevalence of our MRSA isolates in BSI was lower than those reported from China in 2016 and Latin America in 2011–2014 28,29. The detection rate of MRSA among our sputum samples was much higher than that reported from Dongguan and Shenzhen, two cities of Guangdong Province,12,30 but much lower than that reported in a multicenter study in China from 2007 to 2009 31…”

Profil Penggunaan Antibiotik Pada Pasien Pediatri Rujukan Berdasarkan Sistem Defined Daily Dose (DDD)

“…(0,7%), dan E. coli (0,2%) [8]. Resistensi bakteri terjadi dikarenakan pemilihan antibiotik yang tidak tepat, sehingga menjadi masalah kesehatan yang sewaktu-waktu dapat menyebar dan menyebabkan infeksi baru [9,10]. Penelitian yang dilakukan di RSUP Fatmawati Jakarta pada 149 pasien sepsis neonatorum yang menerima antibiotik menunjukkan bahwa terjadi ketidaksesuaian dosis sebesar 20,13% dan frekuensi pemberian antibiotik sebesar 26,17% [11].…”

Detection of Eight Respiratory Bacterial Pathogens Based on Multiplex Real-Time PCR with Fluorescence Melting Curve Analysis

“…Lower respiratory tract infections are among the leading causes of hospitalization and death around the world [1][2][3][4]. e causative agents of lower respiratory tract infections are diverse [5], while respiratory bacterial pathogens remain to be the primary cause [6][7][8][9]. S. aureus, E. coli, and K. pneumoniae commonly cause lower respiratory tract infections in children [7].…”

“…e causative agents of lower respiratory tract infections are diverse [5], while respiratory bacterial pathogens remain to be the primary cause [6][7][8][9]. S. aureus, E. coli, and K. pneumoniae commonly cause lower respiratory tract infections in children [7]. In addition, bacteria such as K. pneumoniae, P. aeruginosa, and S. pneumoniae are also widely recognized as major pathogens of community-acquired pneumonia [10].…”