Antimicrobial resistance in bacteria isolated from peridomestic Rattus species: A scoping literature review

Uea-Anuwong, Theethawat; Byers, Kaylee A.; Wahl, Lloyd Christian; Nekouei, Omid; Gröhn, Yrjö T.; Magouras, Ioannis

doi:10.1016/j.onehlt.2023.100522

Cited by 8 publications

(6 citation statements)

References 62 publications

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“…The inhabiting of diverse habitats including municipal waste water systems, livestock, urban agriculture sites, cemeteries, mortuaries and biomedical/healthcare/hospital wastes disposal sites, makes urban rats' good candidates in the transmission of a wide range of AMR [47]. These pathogens may be spread to homes, and domestic animal populations [48] with widespread reports of multiple drug resistant pathogens being spread by commensal rats [31,32,49,50,51]. Rats are also responsible for nosocomial infection transfer [73], and homes close to healthcare and cemeteries in urban areas may be at a higher risk of infections.…”

Section: Discussionmentioning

confidence: 99%

“…In the previous study, 28% of households who had rodents in their residence come into contact with their urine and droppings and 24% eat rodent contaminated foods [23]. Human interactions with rats in the home provides a pathway of transferring zoonotic illnesses into the human population via direct and indirect route [32]. Contact with rats through scratches or bites, and exposure to their secretions constitute direct transmission route [3,69].…”

Section: Discussionmentioning

confidence: 99%

“…In a recently published study, the common rats; R. norvegicus and its cousin R. rattus were identified in mediating the transfer of multiple drug resistant Enterobacteriaciae from livestock into human environment [48]. In this study, 28 of the 53 E. coli strains and two of the five Salmonella strains identified were multiple drug resistant suggesting urban may be playing a crucial role in the dissemination of antimicrobial resistant pathogens (AMR) [31,32,47,48,49,50,51].…”

Section: Introductionmentioning

confidence: 89%

“…However, over the past six decades, the majority of the 300+ newly identified infectious diseases have stemmed from wildlife with human-wildlife contact serving as a major transmission pathway [29]. Rodents alone provides reservoir of an estimated 50% of emerging zoonotic pathogens and commensal rats are an ecosystem of numerous disease agents with over fifty-three infectious agents identified thus far [3,20,30,31,32,33]. Diseases such as toxoplasmosis, salmonellosis, plague, leptospirosis, rat-bit fever, hemorrhagic fevers, and zoonotic babesiosis have been associated with rats [3,33].…”

Section: Author Summary Introductionmentioning

confidence: 99%

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Exploring rat meat consumption patterns, and perception of risks regarding urban rats; implications for rat-borne zoonoses outbreaks and drug resistant pathogens spread in urban areas of Ghana

Deku,

Younge,

Doggett

et al. 2024

Preprint

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Background This research explores rat meat consumption patterns among urban Ghanaians and their perception of risks associated with urban rats. Two hypotheses on risk perception among urban inhabitants were proposed: the risk of contracting diseases by consuming rat meat and the risk of contracting diseases from peridomestic rats. Method/Principal findings To achieve the objective, a descriptive cross-sectional survey using a questionnaire was conducted that recruited participants from urban settings in Ghana. Of the 829 respondents recruited, around 65% consumed rodents, and of these, 35% consumes rat meat. Through statistical analyses, our data revealed gender, age, region, religion, ethnicity, education, profession and income significantly influenced rat meat consumption and resident's perception of disease risk. An adjusted multivariable model identified males aged 27 to 34years with no formal or a basic education in southern Ghana as the most likely rat meat consumers. The majority of the participants (60.3%) indicated rats are often present in homes and community drains, and have some awareness where rats can be found in their place of residence. Low perception scores regarding disease risks associated with rat meat consumption were recorded, with the majority of respondents (55-74.9% of 829) perceiving that there were minimal disease threats associated with peridomestic rats. The outcome of this belief was that participants undertook limited rat control in their neighborhood. Conclusion/Significance The poor perceptions of disease risks regarding rats increases the vulnerabilities of urban Ghanaians to zoonotic spillovers. This underscores the critical need for public education on rat-borne zoonoses in urban Ghana. This survey presents the first baseline study on urban inhabitant's interactions with rats in Ghana and the data will be crucial in the on-going interventions by the Ghana Health Service to minimize transmission of Lassa fever and other rodent-borne diseases and the spread of rodent related drug resistant pathogens.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 89%

Section: Author Summary Introductionmentioning

confidence: 99%

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Exploring rat meat consumption patterns, and perception of risks regarding urban rats; implications for rat-borne zoonoses outbreaks and drug resistant pathogens spread in urban areas of Ghana

Deku,

Younge,

Doggett

et al. 2024

Preprint

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“…Both mice (Williams et al 2018b) and rats (Uea- Anuwong et al 2023;Gerbig et al 2023) carry multiple antimicrobial-resistant (AMR) bacteria, which indicates their potential as reservoirs or vectors of antimicrobial resistance in urban environments. Rats also harbor many rodent-specific pathogens including herpes, polyoma, and papilloma viruses (Ehlers et al 2007(Ehlers et al , 2015; coronaviruses parvoviruses Mycoplasma sp.…”

Section: Infections Of Commensal Mice and Ratsmentioning

confidence: 99%

Physiological strategies in wild rodents: immune defenses of commensal rats

MIRKOV,

TUCOVIC,

KULAS

et al. 2023

Integr. Zool.

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The importance of issues associated with urban/commensal rats and mice (property damage, management costs, and health risks) press upon research on these animals. While the demography of commensal rodents is mostly studied, the need for understanding factors influencing their natural morbidity/mortality is also stressed. In this respect, more attention is expected to be paid to immunity, the physiological mechanism of defense against host survival threats (pathogens, parasites, diseases). Commensal rats and mice carry numerous pathogens that evoke diverse immune responses. The state of immunity in commensal house mice is studied in great detail, owing to the use of laboratory strains in biomedical research. Because commensal rats are, compared to mice, carriers of more zoonotic agents, rats' immunity is studied mainly in that context. Some of these zoonotic agents cause chronic, asymptomatic infections, which justified studies of immunological mechanisms of pathogen tolerance versus clearance regulation in rats. Occurrence of some infections in specific tissues/organs pressed upon analysis of local/regional immune responses and/or immunopathology. A survey of immunological activity/responses in commensal rats is given in this review, with mention of existing data in commensal mice. It should throw some light on the factors relevant to their morbidity and lifespan, supplementing the knowledge of commensal rodent ecology.

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Antimicrobial resistance and phylogenetic relatedness of extended-spectrum ß-lactamase (ESBL)-producing Escherichia coli in peridomestic rats (Rattus norvegicus and Rattus tanezumi) linked to city areas and animal farms in Hong Kong

Uea-Anuwong,

Biggel,

Cernela

et al. 2024

Environmental Research

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Antimicrobial resistance in bacteria isolated from peridomestic Rattus species: A scoping literature review

Cited by 8 publications

References 62 publications

Exploring rat meat consumption patterns, and perception of risks regarding urban rats; implications for rat-borne zoonoses outbreaks and drug resistant pathogens spread in urban areas of Ghana

Exploring rat meat consumption patterns, and perception of risks regarding urban rats; implications for rat-borne zoonoses outbreaks and drug resistant pathogens spread in urban areas of Ghana

Physiological strategies in wild rodents: immune defenses of commensal rats

Antimicrobial resistance and phylogenetic relatedness of extended-spectrum ß-lactamase (ESBL)-producing Escherichia coli in peridomestic rats (Rattus norvegicus and Rattus tanezumi) linked to city areas and animal farms in Hong Kong

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