Antimicrobial resistance in bacteria associated with porcine respiratory disease in Australia

Dayao, Denise; Gibson, Justine S.; Blackall, P. J.; Turni, Conny

doi:10.1016/j.vetmic.2014.03.014

Cited by 66 publications

(78 citation statements)

References 19 publications

(2 reference statements)

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“…In our study the highest resistance rates were determined to tetracycline (34%) and streptomycin (31%). A significantly higher level of resistance to tetracycline was observed in Spain 85% (14) as well as in Australia 75% (9). Higher levels of resistance of 88.4% and 90.7% for chlortetracycline and oxitetracycline, respectively, were identified in Canada (17).…”

Section: Methodsmentioning

confidence: 93%

Antimicrobial susceptibility of Actinobacillus pleuropneumoniae strains isolated from pig's clinical samples in Serbia

Žutić¹,

Pavlovic²,

Radanović³

et al. 2016

Medycyna Weterynaryjna

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SummaryPorcine pleuropneumonia, caused by Actinobacillus pleuropneumoniae is one of the most important bacterial diseases of the pig respiratory tract. One hundred and forty eight Actinobacillus pleuropneumoniae strains isolated from pig's clinical samples were tested for their susceptibility to 11 antimicrobials by disk diffusion method. Isolates were obtained from the pathoanatomically altered pig's lung that died with signs of respiratory disease. Antimicrobial discs with following concentration were used: ampicillin 10 µg, amoxicillin 10 µg, amoxicillin/clavulanic acid 20/10 µg, cefotaxime 30 µg, gentamicin 10 µg, penicillin 10 IU, streptomycin 10 µg, tetracycline 30 µg, enrofloxacin 5 µg, lincospectin 15/200 µg, florfenicol 30 µg and trimethoprim/sulfamethoxazole 1.25/23.75 µg. Isolated strains showed various susceptibility to tested antimicrobials. Seventy-five percent of isolates were resistant to one or more drugs frequently used in the treatment of pig's diseases at farms in Serbia. All 148 isolates were susceptible to cefotaxime, enrofloxacin and florfenicol, while 96% of them were susceptible to amoxicillin/clavulanic acid and lincospectin. Susceptibility of isolates to amoxicillin, gentamicin and trimethoprim/sulfamethoxazole were 91%, 77% and 64%, respectively. The highest resistance rates were determined for tetracycline and streptomycin, 34% and 31%, respectively. When compared to our previous results, we noticed a decrease in resistance to tetracyclines and trimethoprim/sulfamethoxazole. Our results indicate that A. pleuropneumoniae strains isolated from pig's clinical samples in Serbia show high susceptibility to antimicrobial agents which are most often used in the pig industry.

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Section: Methodsmentioning

confidence: 93%

Antimicrobial susceptibility of Actinobacillus pleuropneumoniae strains isolated from pig's clinical samples in Serbia

Žutić¹,

Pavlovic²,

Radanović³

et al. 2016

Medycyna Weterynaryjna

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“…Ampicillin, tetracycline, and tilmicosin were selected for antimicrobial susceptibility testing in the current study as a recent study has confirmed resistance to these antimicrobials in A. pleuropneumoniae isolates from Australian pigs. 10 The antimicrobial resistance of a bacterial population is often associated with continuous antimicrobial exposure as this selects for resistant strains. 23 Since the study farm used tetracycline and tilmicosin on the pigs involved in the three sampling batches, resistance or decreased susceptibility to these antimicrobial agents was expected.…”

Section: Discussionmentioning

confidence: 99%

“…10 This study showed that of the 71 isolates of A. pleuropneumoniae examined, 75% were resistant to tetracycline, 25% to tilmicosin, and 8.5% to ampicillin. 10 However, this study did not look in depth at the antimicrobial resistance within one farm. The general knowledge about spontaneous mutations and the models developed to predict the mutation rate leads to the conclusion that a bacterial population may consist of susceptible bacteria and mutated bacteria with different degrees of resistance existing in low numbers.…”

Section: Introductionmentioning

confidence: 87%

“…5,13 Unfortunately, resistance has been reported in A. pleuropneumoniae to several antimicrobial agents used to treat pleuropneumoniae. 1,10,14,18,20,29 We have recently investigated antimicrobial resistance in Australian A. pleuropneumoniae isolates. 10 This study showed that of the 71 isolates of A. pleuropneumoniae examined, 75% were resistant to tetracycline, 25% to tilmicosin, and 8.5% to ampicillin.…”

Section: Introductionmentioning

confidence: 99%

“…1,10,14,18,20,29 We have recently investigated antimicrobial resistance in Australian A. pleuropneumoniae isolates. 10 This study showed that of the 71 isolates of A. pleuropneumoniae examined, 75% were resistant to tetracycline, 25% to tilmicosin, and 8.5% to ampicillin. 10 However, this study did not look in depth at the antimicrobial resistance within one farm.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Variation in the Antimicrobial Susceptibility ofActinobacillus pleuropneumoniaeIsolates in a Pig, Within a Batch of Pigs, and Among Batches of Pigs from One Farm

Dayao

Dawson²,

Kienzle

et al. 2015

Microbial Drug Resistance

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Antimicrobial resistance in bacterial porcine respiratory pathogens has been shown to exist in many countries. However, little is known about the variability in antimicrobial susceptibility within a population of a single bacterial respiratory pathogen on a pig farm. This study examined the antimicrobial susceptibility of Actinobacillus pleuropneumoniae using multiple isolates within a pig and across the pigs in three different slaughter batches. Initially, the isolates from the three batches were identified, serotyped, and subsample genotyped. All the 367 isolates were identified as A. pleuropneumoniae serovar 1, and only a single genetic profile was detected in the 74 examined isolates. The susceptibility of the 367 isolates of A. pleuropneumoniae to ampicillin, tetracycline and tilmicosin was determined by a disc diffusion technique. For tilmicosin, the three batches were found to consist of a mix of susceptible and resistant isolates. The zone diameters of the three antimicrobials varied considerably among isolates in the second sampling. In addition, the second sampling provided statistically significant evidence of bimodal populations in terms of zone diameters for both tilmicosin and ampicillin. The results support the hypothesis that the antimicrobial susceptibility of one population of a porcine respiratory pathogen can vary within a batch of pigs on a farm.

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Bordetellosis

Brockmeier¹,

Nicholson³

et al. 2019

Diseases of Swine

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Antimicrobial resistance in bacteria associated with porcine respiratory disease in Australia

Cited by 66 publications

References 19 publications

Antimicrobial susceptibility of Actinobacillus pleuropneumoniae strains isolated from pig's clinical samples in Serbia

Antimicrobial susceptibility of Actinobacillus pleuropneumoniae strains isolated from pig's clinical samples in Serbia

Variation in the Antimicrobial Susceptibility ofActinobacillus pleuropneumoniaeIsolates in a Pig, Within a Batch of Pigs, and Among Batches of Pigs from One Farm

Bordetellosis

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