Antimicrobial resistance in bacteria

Bockstael, Katrijn; Aerschot, Arthur Van

doi:10.2478/s11536-008-0088-9

Cited by 57 publications

(40 citation statements)

References 39 publications

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“…Bockstael and van Aerschot [56] have been describe four major mechanisms of resistance; Target site alterations, such as changes to the penicillin-binding protein, are common, inactivation of antimicrobials, as by penicillinases or the new carbapenemases, is often seen, Prevention of antimicrobial access to their targets by changing the cell wall permeability that denies access to antimicrobials during the course of therapy and Finally, newly described efflux mechanisms pump the antimicrobial out of the cell before it can reach its target site.…”

Section: *Cons; Coagulase Negative Staphylococcimentioning

confidence: 99%

Staphylococcus epidermidis Prevails Staphylococcus aureus in Multispecies Biofilm under Gentamicin Stress

2017

IJSR

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Out of 60 staphylococcal isolates isolated form different sources, the results revealed that 20 and 10 were identified as S. aureus and S. epidermidis, respectively. These results were confirmed by detecting 16sRNA gene. Remarkably, 80% of S. aureus and 80% of S. epidrmidis isolates developed Methicillinresistance. Findings of the current work demonstrated that most of methicillin resistant S. aureus (MRSA) and methicillin resistant S. epidermidis (MRSE) formed weak biofilm. The competition between S. aureus and S. epidermidis in multispecies biofilm were tested at several conditions encompassed temperature, pH, and starvation. Results showed that the numbers of biofilm cells have intensely decrease to undetectable limits in the presence of Gentamicin, approximately, at all tested conditions. With few exceptions, S. epidermidis showed a noticeable dominance in all species combinations.

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Section: *Cons; Coagulase Negative Staphylococcimentioning

confidence: 99%

Staphylococcus epidermidis Prevails Staphylococcus aureus in Multispecies Biofilm under Gentamicin Stress

2017

IJSR

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“…Thus, it represents a selective and promising target for the development of new antibacterial agents. 1 Using structural and mechanistic information together with high throughput screening, several types of potent PDF inhibitors have been identified. PDF inhibitors identified to date share a common structural feature of a "chelator + peptidomimetic" scaffold.…”

Section: Introductionmentioning

confidence: 99%

Untitled

2016

IJPSR

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Peptide deformylase (PDF) is a mononuclear metal ion protein that is responsible for removing the N-formyl group of nascent proteins found in bacteria and chloroplasts in order for them to become mature proteins. From literature it was found that heterocyclic derivatives containing hydroxamic acid and hydroxyl amine exhibit good antibacterial and PDF inhibitory activity. Heterocycles bearing nitrogen, sulphur, oxygen and thiazole moieties constitute the core structure of a number of biologically interesting compounds. Recently 1,3,4 oxadiazole and 1,3,4 -triazole derivatives received significant attention owing to their diverse range of biological properties particularly being antifungal, antitubercular, antibacterial, antiviral, anticancer and antioxidant. Ethyl-cyano-acetate when treated with sodium hydrate and THF give acetate derivatives, which on further treatment with hydrazine hydrate and various reagent afforded heterocyclic hydroxylamine derivatives.

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“…5 Tipicamente, os bactericidas pequenos atuam inibindo alguma enzima (macromolécula) vital. Tal inibição geralmente obstrui a rota bioquímica de uma atividade ou síntese de estrutura celular importante (FIGURA 01).…”

Section: Antibióticos Comerciaisunclassified

“…Tal inibição geralmente obstrui a rota bioquímica de uma atividade ou síntese de estrutura celular importante (FIGURA 01). [5] β-lactâmicos, glicopeptídeos. Observação: a Daptomicina (TABELA 01) é um antimicrobiano desenvolvido recentemente que ataca a membrana celular bacteriana, levando à rápida despolarização do potencial de membrana -já houve indícios do aparecimento de resistência durante as fases de ensaios clínicos.…”

Section: Antibióticos Comerciaisunclassified

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Mecanismos de interação molecular de polieletrólitos antimicrobianos em membranas modelo por espectroscopia vibracional não linear

Rimoli¹

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AGRADECIMENTOSA Deus, por tudo e por cada segundo de vida.A toda minha família, pelo amor, exemplo, suporte e compreensão em todos os momentos. Em especial: Pai, obrigado por me ensinar a ser paciente e organizado; Mãe, obrigado por me ensinar a trabalhar com amor e determinação; Maninha, obrigado por nunca me deixar esquecer que é a companhia das pessoas queridas que faz a vida valer a pena. A todos os docentes dos quais fui aluno -muito obrigado pela dedicação e paciência.Aos funcionários do Serviço da Pós-Graduação do IFSC, Silvio, Ricardo e Priscila, pelo profissionalismo, paciência e atenção.Às meninas da biblioteca, Cris, Neusa e Ana, por sempre serem muito atenciosas, Enfim, a todos os que estiveram presentes nesta longa trajetória, que eu já tenha mencionado ou não: saibam que eu sou um pedacinho de cada um de vocês e eu sou muito grato pela nossa convivência e experiência de vida compartilhada. showed that both PAH and CO led to a small expansion of DPPC monolayers. However, for DPPG monolayers both polyelectrolytes led to significant expansion, with CO causing a more dramatic effect. SFG spectra in the CH stretch range showed that the lipid chain conformation remained always well ordered in all cases (slightly less ordered upon interacting with PAH), despite membrane expansion. This indicates that CO were inserted in the monolayer, forming islands of CO within the lipid film. Changes in the SFG spectral lineshape of OH stretches for the interfacial water molecules indicated that PAH adsorption on both DPPC and DPPG films was able to overcompensate the lipid negative charge and led to an overall surface charge reversal. The SFG spectra of the phosphate groups also indicated that in pure water the DPPC headgroups had a more ordered orientation than in the case of DPPG. Nevertheless, upon interaction with the cationic polyelectrolytes, the DPPG headgroups also become ordered, with a preferential orientation towards the subphase. Experiments with the antimicrobials injected in the subphase under a condensed Langmuir film indicated that CO were also capable of monolayer penetration, albeit causing a reduced film expansion. This comparison indicates that the choice of experimental methodology affects the outcome, but both may be complementary, as they may represent different phases of a biomembrane lifecycle.The detailed view provided here for the molecular interaction of these polyelectrolytes with lipid films may shed light on the mechanism of their biocidal activity and aid on a rational design of new antimicrobial polymers.

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Antimicrobial resistance in bacteria

Cited by 57 publications

References 39 publications

Staphylococcus epidermidis Prevails Staphylococcus aureus in Multispecies Biofilm under Gentamicin Stress

Staphylococcus epidermidis Prevails Staphylococcus aureus in Multispecies Biofilm under Gentamicin Stress

Untitled

Mecanismos de interação molecular de polieletrólitos antimicrobianos em membranas modelo por espectroscopia vibracional não linear

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