Antimicrobial Resistance Gene Delivery in Animal Feeds

Lu, Karen H.; Asano, Rumi; Davies, Julian

doi:10.3201/eid1004.030506

Cited by 31 publications

(16 citation statements)

References 32 publications

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“…Recently, Lu and coworkers (21) found substantial bacterial DNA contamination, including nucleotide sequences consisting of the three genes vanH, vanA, and vanX that are required for high-level resistance to the glycopeptides in animal feedgrade avoparcin. They suggested that the prolonged use of avoparcin in agriculture may have led to the uptake of glycopeptide resistance genes by commensal bacteria in animals, which were subsequently transferred to humans.…”

Section: Discussionmentioning

confidence: 99%

Acquisition of Resistance to Extended-Spectrum Cephalosporins by Salmonella enterica subsp. enterica Serovar Newport and Escherichia coli in the Turkey Poult Intestinal Tract

Poppe

Martin

Gyles³

et al. 2005

Appl Environ Microbiol

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Salmonella enterica subsp. enterica serovar Newport resistant to the extended-spectrum cephalosporins (ESCs) and other antimicrobials causes septicemic salmonellosis in humans and animals and is increasingly isolated from humans, animals, foods, and environmental sources. Mechanisms whereby serovar Newport bacteria become resistant to ESCs and other classes of antimicrobials while inhabiting the intestinal tract are not well understood. The present study shows that 25.3% of serovar Newport strains isolated from the turkey poult intestinal tract after the animals were dosed with Escherichia coli harboring a large conjugative plasmid encoding the CMY-2 ␤-lactamase and other drug resistance determinants acquired the plasmid and its associated drug resistance genes. The conjugative plasmid containing the cmy-2 gene was transferred not only from the donor E. coli to Salmonella serovar Newport but also to another E. coli serotype present in the intestinal tract. Laboratory studies showed that the plasmid could be readily transferred between serovar Newport and E. coli intestinal isolates. Administration of a single dose of ceftiofur, used to prevent septicemic colibacillosis, to 1-day-old turkeys did not result in the isolation of ceftiofur-resistant E. coli or Salmonella serovar Newport. There was a remarkable association between serotype, drug resistance, and plasmid profile among the E. coli strains isolated from the poults. This study shows that Salmonella serovar Newport can become resistant to ESCs and other antibiotics by acquiring a conjugative drug resistance plasmid from E. coli in the intestines.

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Section: Discussionmentioning

confidence: 99%

Acquisition of Resistance to Extended-Spectrum Cephalosporins by Salmonella enterica subsp. enterica Serovar Newport and Escherichia coli in the Turkey Poult Intestinal Tract

Poppe

Martin

Gyles³

et al. 2005

Appl Environ Microbiol

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“…A main concern is a hypothesized horizontal gene transfer to clinically relevant bacteria (22,24), although such a link has never been documented (30). Antibiotic formulations used in animal feeds have been suggested as a potential delivery vehicle for resistance genes (1,8,21), since low-grade formulations have been shown to be contaminated with the resistance genes of producer organism used to prepare formulations (15,28,29). Streptomycin formulations used in plant agriculture are produced using Streptomyces griseus subsp.…”

mentioning

confidence: 99%

Plant Agricultural Streptomycin Formulations Do Not Carry Antibiotic Resistance Genes

Rezzonico

Stockwell

Duffy

2009

Antimicrob Agents Chemother

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Streptomycin is used in plant agriculture for bacterial disease control, particularly against fire blight in pome fruit orchards. Concerns that this may increase environmental antibiotic resistance have led to bans or restrictions on use. Experience with antibiotic use in animal feeds raises the possible influence of formulationdelivered resistance genes. We demonstrate that agricultural streptomycin formulations do not carry producer organism resistance genes. By using an optimized extraction procedure, Streptomyces 16S rRNA genes and the streptomycin resistance gene strA were not detected in agricultural streptomycin formulations. This diminishes the likelihood for one potential factor in resistance development due to streptomycin use.

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“…In these, there is a complex web of much more important sources and factors that affect the stability, recycling, and horizontal transfer of (at least some) ARMGs (Martinez 2009). Occasional or mass-scale delivery of ARMGs, including the aadA gene (Binh et al 2009), into the ecosystem is very well characterized: DNA-contaminated veterinary antibiotics (Lu et al 2004), resistant microbial biocontrol agents (Zhang et al 2006), livestock manure (Heuer et al 2011;Marti et al 2013a;Udikovic-Kolic et al 2014), and waste water or even drinking (including chlorinated) water (Xi et al 2009;Marti et al 2013b;Shi et al 2013) are all identified and proven components of this antibiotic resistance cycle. Through the same channels, also antibiotics are efficiently distributed, which provides an increased pressure for the selection of further antibiotic-resistant microbes.…”

Section: Public Concerns Associated With Transplastomic Plantsmentioning

confidence: 99%

Transplastomic plants for innovations in agriculture. A review

Wani

Sah

Sági

et al. 2015

Agron. Sustain. Dev.

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Food production has to be significantly increased in order to feed the fast growing global population estimated to be 9.1 billion by 2050. The Green Revolution and the development of advanced plant breeding tools have led to a significant increase in agricultural production since the 1960s. However, hundreds of millions of humans are still undernourished, while the area of total arable land is close to its maximum utilization and may even decrease due to climate change, urbanization, and pollution. All these issues necessitate a second Green Revolution, in which biotechnological engineering of economically and nutritionally important traits should be critically and carefully considered. Since the early 1990s, possible applications of plastid transformation in higher plants have been constantly developed. These represent viable alternatives to existing nuclear transgenic technologies, especially due to the better transgene containment of transplastomic plants. Here, we present an overview of plastid engineering techniques and their applications to improve crop quality and productivity under adverse growth conditions. These applications include (1) transplastomic plants producing insecticidal, antibacterial, and antifungal compounds. These plants are therefore resistant to pests and require less pesticides. (2) Transplastomic plants resistant to cold, drought, salt, chemical, and oxidative stress. Some pollution tolerant plants could even be used for phytoremediation. (3) Transplastomic plants having higher productivity as a result of improved photosynthesis. (4) Transplastomic plants with enhanced mineral, micronutrient, and macronutrient contents. We also evaluate field trials, biosafety issues, and public concerns on transplastomic plants. Nevertheless, the transplastomic technology is still unavailable for most staple crops, including cereals. Transplastomic plants have not been commercialized so far, but if this crop limitation were overcome, they could contribute to sustainable development in agriculture.

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Antimicrobial Resistance Gene Delivery in Animal Feeds

Cited by 31 publications

References 32 publications

Acquisition of Resistance to Extended-Spectrum Cephalosporins by Salmonella enterica subsp. enterica Serovar Newport and Escherichia coli in the Turkey Poult Intestinal Tract

Acquisition of Resistance to Extended-Spectrum Cephalosporins by Salmonella enterica subsp. enterica Serovar Newport and Escherichia coli in the Turkey Poult Intestinal Tract

Plant Agricultural Streptomycin Formulations Do Not Carry Antibiotic Resistance Genes

Transplastomic plants for innovations in agriculture. A review

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