Antimicrobial resistance as a global public health threat: the way forward

Abstract

Increased antimicrobial resistance (AMR) of bacterial and fungal pathogens pose a significant threat to public health, as it reduces the effectiveness of antibiotic and other antimicrobial drugs, making the control of infections difficult or almost impossible. This condition arises when microorganisms evolve and develop adaptive mechanisms to withstand the effects of the drugs which are designed to kill them. The emergence and spread of these antimicrobial pathogens that have acquired new resistance mechanisms continue to endanger and undermine efforts to treat common infections. As a result, an increase in morbidity and mortality due to bacterial and fungal infections has been observed with a ripple effect of economic hardship. The primary drivers of AMR include misuse and abuse in human, animal and the environment. To address this threat, it is important to have a good understanding of the cause, consequences, as well as the potential control strategies. Due to the cause and nature of AMR, a multidisciplinary approach is necessary in combating the threat posed by this condition. Some of the strategies through which AMR can be combatted include public health awareness, proper antibiotic use, accurate diagnosis, and research into the development of newer antimicrobial agents and alternative treatments. Additionally, the use of improved surveillance and monitoring systems are important in tracking patterns of resistance and provide guide towards the development of effective intervention strategies. Hence, this review focused on bacterial and fungal resistance to increase awareness and the way forward on this growing threat to human existence