Antimicrobial resistance and the role of vaccines

Bloom, David E.; Black, Steven; Salisbury, David; Rappuoli, Rino

doi:10.1073/pnas.1717157115

Cited by 128 publications

(100 citation statements)

References 13 publications

(13 reference statements)

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“…There is also a need for innovation in trial design (for faster trials with smaller sample sizes, and including collection of valuable biosamples to inform correlates of protection) and in trial analysis, as well as in vaccine delivery. Escalating antimicrobial resistance is a powerful incentive to develop vaccines against bacterial infections, malaria, tuberculosis and HIV infection [108][109][110] . Innovation in the delivery of vaccination programmes is as important as product innovation.…”

Section: The Future Of Immunizationmentioning

confidence: 99%

Immunization: vital progress, unfinished agenda

Piot

Larson

O’Brien

et al. 2019

Nature

146

127

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Section: The Future Of Immunizationmentioning

confidence: 99%

Immunization: vital progress, unfinished agenda

Piot

Larson

O’Brien

et al. 2019

Nature

146

127

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“…Vaccines are not known to have a significant impact on the microbiome, while broad-spectrum antibiotics may disrupt the microbiome, which might lead to the development of resistance in bystander bacterial species (Bloom et al, 2018). Exposure to antibiotics has a rapid and sustained effect on the gut microbiota, reducing diversity (including the loss of non-resistant organisms that provide natural resistance by competing with pathogens for space and nutrients), affecting function (e.g., the regulation of physiological processes), increasing susceptibility to infection, and increasing selection for resistant organisms.…”

Section: By Mechanisms Of Action Less Prone To Inducing Resistancementioning

confidence: 99%

“…In order to use vaccines against AMR, it is important to focus on increasing coverage of existing vaccines and on developing future vaccines against resistant bacterial strains (Bloom et al, 2018). Childhood vaccination programmes have been very successful but a lot more could be done to vaccinate adults and older adults against infectious diseasesthe influenza vaccine alone has the potential to reduce antimicrobial use, while coverage of pneumococcal, tetanus, and diphtheria vaccinations could be improved in adults.…”

Section: Improving Existing Programmes and Expanding New Programmesmentioning

confidence: 99%

“…Many developing countries offer antibiotics over the counter without a prescription, thus use is unregulated and indiscriminate (Levy and Marshall, 2004;Ventola, 2015). As developing countries improve access to antibiotics, education and policy enforcement for their use is imperative to avoid compounding the problem of AMR (Bloom et al, 2018). The widespread use of antibiotics against gram-positive bacteria, for example, contributed to the emergence Figure 1.…”

Section: Introductionmentioning

confidence: 99%

“…Figure 2. Decline of the antibiotic era and rise of vaccines based on licensed products in the US (Bloom et al, 2018). Figure 2 shows the changes in the numbers of antibiotics developed (represented in orange) compared with development of vaccines (represented in blue) over time.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Impact of vaccines on antimicrobial resistance

Buchy¹,

Aşçıoğlu²,

Buisson

et al. 2020

International Journal of Infectious Diseases

121

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Drivers of antimicrobial resistance: Antibiotic use drives the development and spread of resistant bacterial infections. Antimicrobial resistance (AMR) has become a prolific global issue, due to significant increases in antibiotic use in humans, livestock and agriculture, inappropriate use (under-dosing and overprescribing), and misuse of antibiotics (for viral infections where they are ineffective). Fewer new antibiotics are being developed. The problem of AMR: AMR is now considered a key threat to global health, leading to more mortality and increased healthcare costs threatening future conduct of routine medical procedures. Traditional approaches to address AMR include antibiotic stewardship, better hygiene/infection control, promoting antibiotic research and development, and restricting use for agricultural purposes. Vaccines as a tool to reduce AMR: While antibiotic development is declining, vaccine technology is growing. This review shows how vaccines can decrease AMR by preventing bacterial and viral infections, thereby reducing the use/misuse of antibiotics, and by preventing antibiotic-resistant infections. Vaccines are less likely to induce resistance. Some future uses and developments of vaccines are also discussed. Conclusions: Vaccines, along with other approaches, can help reduce AMR by preventing (resistant) infections and reducing antibiotic use. Industry and governments must focus on the development of novel vaccines and drugs against resistant infections to successfully reduce AMR.

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Green Tea Derivative Driven Smart Hydrogels with Desired Functions for Chronic Diabetic Wound Treatment

Zhao

Pei

Yang

et al. 2021

Adv Funct Materials

253

214

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Current treatments for chronic diabetic wounds remain unsatisfactory due to the lack of ideal wound dressings that can integrate matching mechanical strength, fast self‐healability, facile dressing change, and multiple therapeutic effects into one system. In this work, benefiting from the catechol groups and therapeutic effect of epigallocatechin‐3‐gallate (EGCG, green tea derivative), a smart hydrogel dressing can be conveniently obtained through copolymerization of the complex formed by EGCG and 3‐acrylamido phenylboronic acid (APBA) (the formation of boronate ester bond) and acrylamide. The resulting hydrogel features adequate mechanical properties, self‐healing capability, and tissue adhesiveness. Otherwise, the substantial release of EGCG can not only realize anti‐oxidation, antibacterial, anti‐inflammatory and proangiogenic effect, and modulation of macrophage polarization to accelerate wound healing, but also facilitate easy dressing change. This advanced hydrogel provides a facile and effective way for diabetic chronic wound management and may be extended for the therapy of other complicated wound healings.

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Antimicrobial resistance and the role of vaccines

Cited by 128 publications

References 13 publications

Immunization: vital progress, unfinished agenda

Immunization: vital progress, unfinished agenda

Impact of vaccines on antimicrobial resistance

Green Tea Derivative Driven Smart Hydrogels with Desired Functions for Chronic Diabetic Wound Treatment

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