Antimicrobial Resistance and Molecular Characterization of Gene Cassettes from class 1 Integrons in Carbapenem-resistant Escherichia coli strains

Liu, Mi; Liu, Jing; Ma, Jie; Li, Wanxiang; Zhao, Xue; Jia, Wei; Liu, Shirong

doi:10.1016/j.micpath.2022.105669

Cited by 5 publications

(2 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The most common GC combinations identified in this study were dfrA27 + arr-3 , followed by dfrA12 + aadA2, dfrA12 + orf + aadA2, Inu(F) + aadA22 , and dfrA12 + aadA and so on. These findings aligned with previous studies by Liu et al (2022b) , Racewicz et al (2022) , Yu et al (2003) , Zhang et al (2021a) , and Zou et al (2018) , indicating a high degree of similarity in the GCs carried within the VRs of E. coli . In addition, we found a significant correlation between AMR phenotypes of CTX, TE, C, ATM, KAN, AMP, NFX, or SXT and the presence of class 1 integrons, which showed much more positive associations than our previous studies ( Zhang et al, 2021a ).…”

Section: Discussionsupporting

confidence: 92%

High rate of multidrug resistance and integrons in Escherichia coli isolates from diseased ducks in select regions of China

et al. 2023

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 92%

High rate of multidrug resistance and integrons in Escherichia coli isolates from diseased ducks in select regions of China

et al. 2023

View full text Add to dashboard Cite

“… 16 This might be due to either absence of genes or additional mechanisms such as efflux pumps related to carbapenem resistance or innately weaker promoter resulting in weaker expression. 17 The antimicrobial resistance against fluoroquinolones was also strongly associated with the presence of integrons in our study. Many studies have reported this association previously in terms of presence of plasmid-mediated quinolones resistance (PMQR) genes, however, they could not detect any resistance gene directly from the integrons.…”

Section: Discussionsupporting

confidence: 64%

Integrons and multidrug resistance across phylogenetic groups of clinical isolates of Escherichia coli

Razzaq,

Sheraz,

Mohsin

et al. 2024

Pak J Med Sci

View full text Add to dashboard Cite

Objective: This study was aimed to investigate the multidrug resistance patterns in clinical isolates of Escherichia coli and their correlation with integrons and phylogenetic groupings. Methods: A total of 37 clinical E. coli isolates were evaluated for drug resistance patterns by disk diffusion method. Phylogenetic groupings and the presence of integrons among E. coli were determined by multiplex PCR assays. Results: Multidrug resistance was identified in 84% of the clinical isolates of E. coli with higher resistance found against cephalosporins (94.6%) and fluoroquinolones (83.8%), while lower resistance was observed against polymyxins (24.3%) and carbapenems (29.7%). Metallo-β-lactamases were found in all carbapenem resistant isolates. The phylogenetic group B2 was the most dominant (40.5%), followed by groups A (35.1%), D (13.5%) and B1 (10.8%). Integrons were detected in 25 (67.6%) isolates and intI1, intI2, and intI3 genes were found in 62.2%, 18.9% and 10.8% of isolates respectively. Conclusion: Our results show that phylogenetic classification of E. coli is not relevant with antimicrobial resistance. However, there was strong association between the integron classes and resistance against β-lactam and fluoroquinolones antimicrobials. Additionally, this study highlighted that the presence of integrons plays a crucial role in the development of multidrug resistance in clinical isolates of E. coli. Most significantly, this is the first report of detection of three classes of integron among clinical isolates of E. coli in Pakistan. doi: https://doi.org/10.12669/pjms.40.6.8886 How to cite this: Razzaq R, Sheraz A, Arshad MM, Awan AB, Haque A. Integrons and multidrug resistance across phylogenetic groups of clinical isolates of Escherichia coli. Pak J Med Sci. 2024;40(6):1190-1195. doi: https://doi.org/10.12669/pjms.40.6.8886 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

show abstract

Molecular Characterization of Class 1 Integrons and Carbapenem-Resistant Genes in Enterobacter cloacae Complex Isolates

Zhu,

Wang,

Zhu

et al. 2024

Curr Microbiol

View full text Add to dashboard Cite

Antimicrobial Resistance and Molecular Characterization of Gene Cassettes from class 1 Integrons in Carbapenem-resistant Escherichia coli strains

Cited by 5 publications

References 22 publications

High rate of multidrug resistance and integrons in Escherichia coli isolates from diseased ducks in select regions of China

High rate of multidrug resistance and integrons in Escherichia coli isolates from diseased ducks in select regions of China

Integrons and multidrug resistance across phylogenetic groups of clinical isolates of Escherichia coli

Molecular Characterization of Class 1 Integrons and Carbapenem-Resistant Genes in Enterobacter cloacae Complex Isolates

Contact Info

Product

Resources

About