Antimicrobial Resistance Among Uropathogens That Cause Childhood Community-acquired Urinary Tract Infections in Central Israel

Yakubov, Renata; Akker, Machiel van den; Machamad, Kaba; Hochberg, Amit; Nadir, Erez; Klein, Adi

doi:10.1097/inf.0000000000001373

Cited by 17 publications

(17 citation statements)

References 29 publications

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“…This study showed that bacterial pathogens causing UTI among diabetics exhibit high multi-drug resistance rates. This has also been revealed in different studies conducted in various regions like Sudan, United Arab Emirates, Ethiopia, Libya, Australia and Israel [6, 9-13]. A study carried out in Ethiopia showed that over 60% of the isolated E. coli was resistant to ampicillin [10].…”

Section: Discussionmentioning

confidence: 69%

Uropathogens antibiotic resistance patterns among type 2 diabetic patients in Kisii Teaching and Referral Hospital, Kenya

Mogaka¹,

Gatwiri²,

Njoroge³

2018

Pan Afr Med J

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IntroductionNon-insulin dependent diabetes mellitus is a major risk factor for urinary tract infections. Irrational use of antibiotics has led to the emergency of uropathogens resistant to available antibiotics. The main objective was to determine the bacterial causative agents of urinary tract infections and their antibiotic resistance patterns.MethodsOne hundred and eighty (180) type 2 diabetic patients were recruited to take part in the study. Urine samples were collected and cultured for urinary tract infections diagnosis and antibiotic sensitivity.ResultsA total of 35 isolates were obtained from the study. All the isolates were sensitive to gentamicin. All 21 (100%) isolates of E. coli were sensitive to gentamicin and cephalexin. All 10 (100%) K. pneumoniaeisolates were sensitive to gentamicin and nitrofurantoin. Out of the 21 E. coli isolates, five of them showed resistance to ampicillin, three E. coli isolates showed resistance to nitrofurantoin and another three E. coliisolates showed resistance to co-trimoxazole. Out of 10 K. pneumoniae isolates, two of them were found to be resistant to ampicillin, one K. pneumoniae isolate was resistant to cephalexin and two K. pneumoniaeisolates were resistant to co-trimoxazole. Out of the four P. mirabilis isolates, there were three cases where one isolate was each resistant to ampicillin, nitrofurantoin and co-trimoxazole.ConclusionThere is a need to have a regular screening of bacterial isolates causing urinary tract infection in diabetic patients and their antibiotic sensitivity in order to have effective therapy. Present findings show that there is increased resistance to the commonly prescribed antibiotics.

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Section: Discussionmentioning

confidence: 69%

Uropathogens antibiotic resistance patterns among type 2 diabetic patients in Kisii Teaching and Referral Hospital, Kenya

Mogaka¹,

Gatwiri²,

Njoroge³

2018

Pan Afr Med J

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“…Another study performed in Israel during the years 2007-2014 reported ceftriaxone resistance rates of common pathogens to be £4.2%. 25 Similarly, a study published in 2013 in the USA reported on a resistance rate of less than 2% among 25,418 outpatient urinary isolates. 2 In our study, the yearly resistance rates to gentamicin remained stable and never exceeded 9%.…”

Section: Figmentioning

confidence: 97%

“…A retrospective study performed in 2017 in Israel, on 829 pediatric urinary isolates, found that the resistance rate of E. coli to ampicillin and first-generation cephalosporins reached *60% and to amoxicillin/clavulanate and TMP-SMX, nearly 30%. 25 During the years 2010-2017, over 30% of the isolated bacteria were resistant to ampicillin, with an increasing trend ( p = 0.0044) from 33.3% in 2010 to a peak resistance rate of 76.4% in 2014. According to our results, ampicillin should remain as a treatment, specifically for UTIs caused by Enterococcus spp.…”

Section: Figmentioning

confidence: 98%

Trends in Distribution and Antibiotic Resistance of Bacteria Isolated from Urine Cultures of Children in Northern Israel Between 2010 and 2017

Graif

Abozaid

Peretz

2020

Microbial Drug Resistance

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Objectives: To identify the changing trends of uropathogens over the years 2010-2017 and examine the incidence of both antibiotic resistance and extended spectrum beta lactamases (ESBL)-producing Enterobacteriaceae in urine cultures from pediatric patients. Study Design: Electronic medical records of 1,056 children, admitted to the Poriya Medical Center in Israel, between 2010 and 2017 with positive urine cultures, were reviewed for bacterial species and antibiotics resistance. Results: The leading pathogen was Escherichia coli (76%), followed by Klebsiella (7%), Enterococcus (5.8%), and Proteus (4%). Statistically significant gender-specific and ethnicity-specific differences in the distribution of uropathogens were found. E. coli was more common in females compared to males. Escherichia coli constituted most (92.3%) of the ESBL-positive cultures, while only 4.6% isolates carried Klebsiella, 1.5% carried Enterobacter spp., and 1.5% carried Morganella. Prevalence of ESBL-producing E. coli increased throughout the study period. Increasing prevalence over time was noted for ceftriaxone, cefuroxime, amoxicillin/clavulanate, and ampicillin resistance. Conclusions: Gender and ethnic background should be taken into consideration when choosing empiric antibiotic therapy for urinary tract infections in children. Similarly, the continuous increase in resistance to cefuroxime and amoxicillin/clavulanate should be considered when prescribing therapy in Israel. Ceftriaxone and gentamicin are still the antibiotics of choice for inpatient parenteral empiric treatment.

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“…6 Aggressive treatment of UTI is mandatory in children within 3 days of arrival in OPD to prevent renal damage (when culture sensitivity report is awaited), delay in treatment often leads to increased severity of infection with greater incidence of renal damage. 7 Etiology and resistance pattern of urinary tract infection acquired through community is generally not available and if available is outdated as resistance pattern of bacteria to antimicrobials often changes periodically in a given region. The etiological agents responsible for causing UTI are different in different region and their variability changes with geographical location, time and age of the patients.…”

Section: Introductionmentioning

confidence: 99%

Management of urinary tract infections in children: antimicrobial sensitivity pattern, efficacy and pharmacoeconomics

Yadav¹,

Pathak²

2019

Int J Basic Clin Pharmacol

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Background: Urinary tract infections are commonly seen in febrile children, high incidence of Vesico Ureteral Reflux (VUR) is frequently seen in paediatric patient which is of concern as it may lead to renal scarring. Despite presence of established clinical guidelines there is disparity amongst physician in the diagnosis and treatment of UTI, some physician prescribes taking into consideration the symptoms, some prescribe on the basis of smell and colour and some rely on urine culture and sensitivity report. There is dearth of studies in many tertiary health care centers regarding antimicrobial use. Authors conducted this study to evaluate antimicrobial sensitivity pattern, efficacy and cost effectiveness of antimicrobials used for UTI in children.Methods: Patients of urinary tract infection <13 years of age were included in the study. Symptoms of patient i.e. pain in abdomen, haematuria, increased frequency of urination and degree of fever were recorded. Efficacy was measured through calculating degree of defervescence per hour. Cost effective model was prepared by calculating cost effective ratio i.e. dividing cost of antimicrobial required to bring down the fever and degree through which fever came down.Results: E. coli was the most common pathogen isolated from urine positive culture (69.07%). Nitrofurantoin has shown highest sensitivity to all uropathogens (72.73%). Cotrimoxazole, ciprofloxacin and nitrofurantoin were found to be most cost effective.Conclusions: In this current study authors found E coli is the most common uropathogen isolated. Ceftriaxone, cefixime, cotrimoxazole and amikacin were found to be most efficacious. Cotrimoxazole, ciprofloxacin and nitrofurantoin were found to be most cost effective.

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Antimicrobial Resistance Among Uropathogens That Cause Childhood Community-acquired Urinary Tract Infections in Central Israel

Cited by 17 publications

References 29 publications

Uropathogens antibiotic resistance patterns among type 2 diabetic patients in Kisii Teaching and Referral Hospital, Kenya

Uropathogens antibiotic resistance patterns among type 2 diabetic patients in Kisii Teaching and Referral Hospital, Kenya

Trends in Distribution and Antibiotic Resistance of Bacteria Isolated from Urine Cultures of Children in Northern Israel Between 2010 and 2017

Management of urinary tract infections in children: antimicrobial sensitivity pattern, efficacy and pharmacoeconomics

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